Medical Genetics
Multidrug resistance gene and its relationship to ulcerative colitis and immune status of ulcerative colitis
Authors: Y.J. Zhang1, J.J. Xu1, P. Wang2 and J.L. Wang1
We examined the relationship among the multidrug resistance (MDR1) gene product P-glycoprotein (P-gp), ulcerative colitis, and immune status under ulcerative colitis. MDR1 P-gp expression and interleukin-8 levels in ulcerative colitis were determined using immunohistochemistry and a double-antibody sandwich avidin-biotin complex-enzyme-linked immunosorben.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.19.5
- DOI:
- 10.4238/2014.December.19.5
Prediction of phosphorylation sites based on the integration of multiple classifiers
Authors: R.Z. Han, D. Wang, Y.H. Chen, L.K. Dong and Y.L. Fan
Phosphorylation is an important part of post-translational modifications of proteins, and is essential for many biological activities. Phosphorylation and dephosphorylation can regulate signal transduction, gene expression, and cell cycle regulation in many cellular processes. Phosphorylation is extremely important for both ba.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019354
- DOI:
- 10.4238/gmr16019354
Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine
Authors: S.M.A. Limeiras, B.C. Oliveira, L.R. Pessatto, J.R. Pesarini, C.A.L. Kassuya, A.C.D. Monreal, W.B. Cantero, R. Antoniolli-Silva, A.C.M.B. Antoniolli-Silva, M.E.A. Stefanello, R.J. Oliveira
The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment,.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019518
- DOI:
- 10.4238/gmr16019518
Characterization of novel nitrate reductase-deficient mutants for transgenic Dunaliella salina systems
Authors: L.J. Gao, Y.L. Jia, S.K. Li and L.L. Qiu
The aim of the present study was to isolate and characterize novel nitrate reductase (NR)-deficient mutants, which may be useful for the transgenic manipulation of Dunaliella salina. Three NR-deficient mutants of D. salina, J-1, J-2, and J-3, were successfully isolated by screening for chlorate resistance after chemical mutagenesis with ethylnitrosourea. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.25
- DOI:
- 10.4238/2015.October.26.25
Role of interleukin-6 gene polymorphisms in the development of prostate cancer
Authors: C.H. Chen, M. Gong, Q.T. Yi and J.H. Guo
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. A total of 212 consecutive primary prostate cancer patients and 236 control subjects were recruited between May 2012 and May 2014. The IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796) polymorp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.34
- DOI:
- 10.4238/2015.October.26.34
Sequence and phylogenetic analyses of the M and N genes of porcine epidemic diarrhea virus (PEDV) strains in Anhui Province, China
Authors: P. Sun, C.Y. Gu, Y.Y. Ding, J.H. Wei, Z.J. Yin, Z.Y. Geng and Y. Li
To assess the homology and phylogenetic relationship between porcine epidemic diarrhea virus (PEDV) Anhui strains and other PEDV strains, molecular homology and phylogenetic analyses of Anhui PEDV field strains were compared with those of reference strains. The results revealed that the M and N genes of PEDV were 681 and 1326 bp long, respectively. The nu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.2
- DOI:
- 10.4238/2015.October.28.2
Effect of retinoic acid on aquaporin 3 expression in keratinocytes
Authors: F. Xing W. Liao P. Jiang W. Xu X. Jin
To explore the possible mechanism of the third-generation retinoic acid drugs (isotretinoin, acitretin, adapalene) in inducing skin and mucosa dryness and rhagades; specifically, mechanism by which these drugs influence keratinocyte cell culture models in vitro (HaCaT) and aquaporin channel (AQP3) protein expression was investigated. Isotretinoin, acitret.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016951
- DOI:
- 10.4238/gmr.15016951
Lack of association between the cyclooxygenase 2 -765G>C polymorphism and prostate cancer risk: a meta-analysis
Authors: Y.-Q. Feng, Y.U. Li, W.-D. Xiao, G.-X. Wang and Y.O. Li
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis. A systematic literature search was performed using the PubMed, Embase, Cochrane Library, and Google Scholar databases by using the terms “cyclooxygenase-2/COX-2/PTGs2”.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.1
- DOI:
- 10.4238/2015.October.28.1
Genetic diversity of Yersinia pestis in Brazil
Authors: M.B.M. Oliveira M.P.S. Barros V.M. Silveira-Filho M.R. Ara�ºjo-Nepomuceno V.Q. Balbino N.C. Leal A.M.P. Almeida T.C. Leal-Balbino
Plague outbreaks are occasionally reported in Brazil. Unfortunately, due to great genetic similarity, molecular subtyping of Yersinia pestis strains is difficult. Analysis of multiple-locus variable number of tandem repeats (VNTR), also known as MLVA, has been found to be a valuable tool to discriminate among strains. To check for genetic differences, str.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.10
- DOI:
- 10.4238/2012.September.25.10
Correlation between expression and significance of �´-catenin, CD31, and VEGF of non-small cell lung cancer
Authors: X.L. Liu, L.D. Liu, S.G. Zhang, S.D. Dai, W.Y. Li and L. Zhang
We analyzed the expression and clinical significance of δ-catenin in non-small cell lung cancer (NSCLC) and investigated prognosis using human lung cancer samples. Eighty-nine NSCLC patients underwent operation between January and March 2009. There were 53 cases of squamous cell carcinoma, 31 adenocarcinoma, and 5 large cell carcinoma. δ-Caten.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.10
- DOI:
- 10.4238/2015.October.28.10