Medical Genetics
Characterization of Riemerella anatipestifer CH-1 gldJ gene and GldJ protein
Authors: B. Yuan1,2, A.C. Cheng1,2,3 and M.S. Wang1,2,3
Riemerella anatipestifer (RA) CH-1, a highly virulent field strain, was isolated and identified by our laboratory. The gldJ gene was conserved in RA, and it had a typical TATA promoter region and AU-rich sequence within the 5' untranslated region. The GldJ protein was an outer-membrane lipoprotein with a signal peptide cleavage site between amino acids 20.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.9
- DOI:
- 10.4238/2014.October.20.9
Protective effect of thymoquinone on cholestatic rats with liver injury
Authors: L.Y. Kong, G.P. Li, P. Yang and Z. Xi
The aim of this study was to investigate the protective effects of thymoquinone treatment on cholestatic rats with liver injury. Thirty-two Sprague-Dawley rats were divided randomly into four groups: normal control, bile duct ligation model control, low-dose thymoquinone (25 mg/kg), and high-dose thymoquinone (50 mg/kg). Thymo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.13
- DOI:
- 10.4238/2015.October.9.13
Cloning and functional identification of a novel BCA3 splice
Authors: Y. Zhang, M.Y. Hu, C.X. Qiao, J.N. Feng, Z. Lin, B.F. Shen2, Y.F. Ma, Y. Li, Y.L. Li and M.
The human breast cancer-associated gene (BCA3) was first discovered in breast and prostate cancer cells lines. In vivo studies have shown that BCA3 is mainly expressed in breast tumor cells and not in normal breast and prostate tissues. To date, 3 splice variants of BCA3 have been reported: a double-absent variant lacking exon 3 and exon 5 (BCA3-1), an ex.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.7
- DOI:
- 10.4238/2014.December.18.7
Genetic polymorphisms in metabolic enzymes and susceptibility to anti-tuberculosis drug-induced hepatic injury
Authors: F.M. Feng1, M. Guo1, Y. Chen1, S.M. Li2, P. Zhang2, S.F. Sun3 and G.S. Zhang1
We examined the relationships between N-transacetylase 2 (NAT2), cytochrome P450 (CYP) 2E1 enzyme, glutathione S-transferase M1, T1 (GSTM1/GSTT1) gene polymorphisms, and anti-tuberculosis drug-induced hepatic injury (ADIH). A one-to-one matched case-control study was carried out using clinical data. NAT2, CYP2E1, GSTM1, and GSTT1 polymorphisms were identi.. Read More»
- Genet. Mol. Res. 13(4):
Multivariate analysis in a genetic divergence study of Psidium guajava
Authors: A.M. Nogueira, M.F.S. Ferreira, J.H.S. Guilhen and A. Ferreira
The family Myrtaceae is widespread in the Atlantic Forest and is well-represented in the Espírito Santo State in Brazil. In the genus Psidium of this family, guava (Psidium guajava L.) is the most economically important species. Guava is widely cultivated in tropical and subtropical countries; however, the widespread cultivation of only a small num.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.8
- DOI:
- 10.4238/2014.December.18.8
Combination of multiple gene markers to detect circulating tumor cells in the peripheral blood of patients with non-small cell lung cancer using real-time PCR
Authors: M. Ding, X. Li and T. Qiu
Our study aims to determine the clinical significance of human telomerase reverse transcriptase (hTERT), S-phase kinase-associated protein 2 (Skp2) and thyroid transcription factor-1 (TTF-1) mRNA expressions in peripheral blood (PB) of patients with non-small cell lung cancer (NSCLC). Real-time polymerase chain reaction was used to investigate the gene ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.24
- DOI:
- 10.4238/2015.October.21.24
Influence of ERCC2 gene polymorphisms on the treatment outcome of osteosarcoma
Authors: Z.F. Liu, A.L.J. Asila, K. Aikenmu, J. Zhao, Q.C. Meng and R. Fang
We conducted a prospective study to investigate the role of ERCC2 gene polymorphisms on the outcome of cisplatin-based treatment in patients with osteosarcoma. A total of 115 patients with osteosarcoma were included in our study. Genotyping of ERCC2 Asn312Asp (rs1799793) and Lys751Gln (rs13181) was performed using a matrix-assisted laser desorption/ioniza.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.17
- DOI:
- 10.4238/2015.October.21.17
Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease
Authors: C.M. Yun and X.Y. Sang
We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.18
- DOI:
- 10.4238/2015.October.26.18
Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis
Authors: Y. Du, L. Gao , K. Zhang and J. Wang
The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.20
- DOI:
- 10.4238/2015.October.26.20
Distribution of mitochondrial DNA fragments in the nuclear genome of the honeybee
Authors: W.X. Du and Y.C. Qin
Nuclear mitochondrial pseudogenes (numts), which originated from mitochondrial DNA (mtDNA) insertions in the nuclear genome, have been detected in many species. The distribution of numts in the honeybee nuclear genome has not yet been fully reported. By referring to the whole honeybee mtDNA sequence and to the recent version of the honeybee nuclear genome.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.35
- DOI:
- 10.4238/2015.October.26.35