Human Genetics
Diversity and genetic structure of mangaba remnants in states of northeastern Brazil
Authors: J.A.E. Amorim, L.R. Mata, A.S. L�©do, V.C.R. Azevedo andA.V.C. Silva
In this study, we analyzed the genetic diversity and structure of remnants of mangaba populations in states of northeastern Brazil by applying 9 microsatellite markers previously developed to establish conservation strategies for germplasm and species preservation. Six to 20 individuals per population were analyzed, with a total of 94 individuals and 6 po.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.7
- DOI:
- 10.4238/2015.February.2.7
Small molecule-enrichment analysis in response to osmotic stimuli in the intervertebral disc
Authors: H. Ma Y.Z. Xie J. Zhao B. Ye
The intervertebral disc (IVD) is a heterogeneous structure that contributes to load support and flexibility in the spine. IVD cells experience a broad range of physical stimuli under physiological conditions, including alterations in their osmotic environment. To date, the molecular mechanisms regulating the response of IVD to osmotic pressure are still not .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.9.2
- DOI:
- 10.4238/2012.October.9.2
6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo
Authors: R.J. Oliveira, M.S. Mantovani, J.R. Pesarini, M.O. Mauro,A.F. da Silva, T.R. Souza and L.R. Ribeiro
The compounds 6-dimethylaminopurine (6-DMAP) and cyclohexamide (CHX) are currently used to stimulate the development of embryos produced by nuclear transfer in the production of cloned mammals with a great deal success. This study investigated the effects of 6-DMAP and CHX in vivo using biological assays to evaluate reproductive performance in females, terat.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.8
- DOI:
- 10.4238/2015.February.2.8
Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population
Authors: X.H. Wang, F.R. Wang, Y.F. Tang, H.Z. Zou and Y.Q. Zhao
We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.20
- DOI:
- 10.4238/2014.July.4.20
Distribution and clinal trends of the ABO and Rh genes in select Middle Eastern countries
Authors: E.S. AlSuhaibani, N.A. Kizilbash, K. Afshan and S. Malik
An understanding of the ABO and Rh blood group systems is important for blood transfusions and is also pertinent due to their potential association with certain morbidities and susceptibilities to infections. To investigate the diversity and differentiation of the ABO and Rh loci in Middle Eastern populations, data from twelve representative Middle Easter.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.12
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.12
Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis
Authors: L.-D. Liu, X.-Y. Wu, B.-D. Tao, N. Wang and J. Zhang
This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung i.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016050
- DOI:
- 10.4238/gmr.15016050
Association between SNPs in genes involved in folate metabolism and preterm birth risk
Authors: B.J. Wang, M.J. Liu, Y. Wang, J.R. Dai, J.Y. Tao, S.N. Wang,N. Zhong and Y. Chen
We investigated the association between 12 single nucleotide polymorphisms (SNPs) in 11 genes involved in folate metabolic and preterm birth. A subset of SNPs selected from 11 genes/loci involved in the folic acid metabolism pathway were subjected to SNaPshot analysis in a case-control study. Twelve SNPs (CBS-C699T, DHFR-c594+59del19, GST01-C428T, MTHFD-G.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.9
- DOI:
- 10.4238/2015.February.2.9
Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats
Authors: C. Liu, J. Cai, Z. Cheng, X. Dai, L. Tao, J. Zhang and D. Xue
Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.15
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.15
Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases
Authors: Z.-Y. Li, F. Shan, L.-H. Zhang, Z.-D. Bu, A.-W. Wu, X.-J. Wu, X.-L. Zong, S.-X. Li, X. Ji and J.-F. Ji
Gastric cancer is the fourth most common cancer worldwide and the leading cause of tumor-related death in China. Gastric cancer is a heterogeneous disease and therefore requires different treatments based on the subtype. We describe a patient who had gastric cancer with liver metastases. Biopsy and tumor analysis using the HercepTest revealed a human epid.. Read More»
- Genet. Mol. Res. 13(4):
- 2014
- DOI:
- 10.4238/2014
Cohn process influences the functional anticoagulant activity of human protein C
Authors: Z.K. Wang, X. Du1, Y.M. Wang, C.Q. Li, F.Z. Lin, H.J. Cao, S.L. Ye, J.J. Hu and J. Yuan
Cohn fraction IV (CFIV) is a byproduct of a plasma fractionation process known as the Cohn process. It is an inexpensive source of protein C, retaining about 90% of protein C (PC) in human plasma. We investigated whether PC is affected during the Cohn process and evaluated correlations among coagulant activity, amidolytic activity and PC antigen during the C.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.10
- DOI:
- 10.4238/2015.February.2.10