Human Genetics
Construction of polycythemia vera protein interaction network and prediction of related biological functions
Authors: L.-J. Liu1, X.-J. Cao2, C. Zhou1, Y. Sun3, Q.-L. Lv3, F.-B. Feng1, Y.-Y. Zhang4 and C.-G. Sun1
Here, polycythemia vera (PV)-related genes were screened by the Online Mendelian Inheritance in Man (OMIM), and literature pertaining to the identified genes was extracted and a protein-protein interaction network was constructed using various Cytoscape plugins. Various molecular complexes were detected using the Clustervize plugin and a gene ontology-enr.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017169
- DOI:
- 10.4238/gmr.15017169
Effects of intermittent hypobaric hypoxia preconditioning on the expression of neuroglobin and Bcl-2 in the rat hippocampal CA1 area following ischemia-reperfusion
Authors: Q. Wu, K.X. Yu, Q.S. Ma and Y.N. Liu
This study was aimed at understanding the effect of intermittent hypobaric hypoxia preconditioning (IHHP) on neuroglobin (NGB) and Bcl-2 expression in the hippocampal CA1 region of rats following global cerebral ischemia-reperfusion. Wistar rats were randomly divided into sham, IHHP control, global cerebral ischemia-reperfusion (IR group), and IHHP+IR gro.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.18
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.18
Proteomic changes in maize as a response to heavy metal (lead) stress revealed by iTRAQ quantitative proteomics
Authors: G.K. Li1,3*, J. Gao4*, H. Peng1,2, Y.O. Shen1, H.P. Ding1, Z.M. Zhang1, G.T. Pan1 and H.J. Lin1
Lead (Pb), a heavy metal, has become a crucial pollutant in soil and water, causing not only permanent and irreversible health problems, but also substantial reduction in crop yields. In this study, we conducted proteome analysis of the roots of the non-hyperaccumulator inbred maize line 9782 at four developmental stages (0, 12, 24, and 48 h) under Pb pol.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017254
- DOI:
- 10.4238/gmr.15017254
Efficacy of dendritic cell-cytokine-induced killer immunotherapy plus intensity-modulated radiation therapy in treating elderly patients with esophageal carcinoma
Authors: L. Yan, M. Wu, N. Ba, L.J. Wang, H.Q. Zhang, G.Y. Shi, Z.S. Zhang and X.J. Wang
We investigated the clinical efficacy of adoptive cytokine-induced killer (CIK) cell and dendritic cell (DC) therapy plus intensity-modulated radiation therapy (IMRT) for treating elderly patients with esophageal carcinoma (EC). In total, 68 elderly patients with EC were randomized to receive IMRT plus DC-CIK immunotherapy (study group, N = 34) or IMRT on.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.13
- DOI:
- 10.4238/2015.February.2.13
Responsivity to PGE2 labor induction involves concomitant differential prostaglandin E receptor gene expression in cervix and myometrium
Authors: C.K. Konopka, W.G. Glanzner, M.L. Rigo, M.T. Rovani, F.V. Comim, P.B.D. Gon�§alves, E.N. Morais, A.Q. Antoniazzi, C.F. Mello and I.B.M. Cruz
Prostaglandin E2 (dinoprostone) is largely used for labor induction. However, one-third of patients do not respond to treatment. One cause of this poor response may be associated with changes in regulation of prostaglandin E receptors (EP1-4). In this study, we investigated EP mRNA expression in the uterine cervix and lower uterine segment myometrium for .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.25
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.25
Correlation between chromosome 1p/19q status and VEGF mRNA expression in gliomas
Authors: B. Yang1*, X.Q. Hao2*, X.W. Zeng3, T.L. Ji3, S. Pan3 and Y.G. Feng1
The chromosome 1p/19q deletion has been reported as a good prognosis marker for gliomas. However, the detection of 1p/19q status alone in glioma patients is not sufficient. The identification of a combination of molecular factors could effectively enhance the prediction accuracy. Thus far, the potential correlation between the 1p/19q status and vascular e.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017322
- DOI:
- 10.4238/gmr.15017322
EPHX1 Tyr113His and His139Argpolymorphisms in esophageal cancer risk: a meta-analysis
Authors: X. Tan, W.W. He, Y.Y. Wang, L.J. Shi and M.W. Chen
Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) po.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.10
- DOI:
- 10.4238/2014.January.28.10
Vascular endothelial growth factor as an angiogenesis biomarker for the progression of autosomal dominant polycystic kidney disease
Authors: D.P. Martins1, M.A. Souza1, M.E. Lopes Baitello1, V. Nogueira1, C.I. Ferreira Oliveira1, M.A. de Souza Pinhel1, H.C. Caldas2, M.A. Filho2 and D.R. Silva Souza1
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary nephropathy characterized by abnormal growth of epithelial cells. Genetic factors, including the vascular endothelial growth factor (VEGF) gene, play an important role in its progression. The main aim of this study was to evaluate the influence of VEGF-C936T polymorphism in the developme.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017623
- DOI:
- 10.4238/gmr.15017623
Clinical characteristics of men with non-mosaic Klinefelter syndrome in northeastern China: implications for genetic counseling
Authors: M. Zhang, H.-T. Fan, H.-S. Zheng, Q.-S. Zhang, S.-Q. Feng and R.-W. Li
Klinefelter syndrome (KS) is the most common genetic cause of male infertility. Widespread development in assisted reproductive technology has provided non-mosaic KS patients with the opportunity of having biological children. Testosterone replacement therapy and micro-dissection testicular sperm extraction are effective sperm retrieval techniques for KS .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.27
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.27
5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/�²-catenin signaling pathway
Authors: H. Zhang, W.C. Zhou, X. Li, W.B. Meng, L. Zhang, X.L. Zhu, K.X. Zhu, Z.T. Bai, J. Yan, T. Liu, X.C. Xu and Y.M. Li
5-Azacytidine has been shown to be an effective anti-pancreatic cancer drug, but the mechanism remains unknown. In the current study, we explored the effect of 5-azacytidine on abnormal activation of the Wnt-β-catenin signaling pathway in pancreatic cancer cells. The human pancreatic cancer cell line Bxpc-3 was treated wi.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.22
- DOI:
- 10.4238/2014.July.4.22