Human Genetics
Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia
Authors: C. Fei, X.M. Yao, Y. Sun, X.Z. Gu, L.Q. Yu and X. Lai
We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province bet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.15
- DOI:
- 10.4238/2015.February.2.15
Identifying human disease genes: advances in molecular genetics and computational approaches
Authors: S.M. Bakhtiar, A. Ali, S.M. Baig, D. Barh, A. Miyoshi and V. Azevedo
The human genome project is one of the significant achievements that have provided detailed insight into our genetic legacy. During the last two decades, biomedical investigations have gathered a considerable body of evidence by detecting more than 2000 disease genes. Despite the imperative advances in the genetic understandin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.23
- DOI:
- 10.4238/2014.July.4.23
Setup errors in cone-beam computed tomography and their effects on acute radiation toxicity in cervical cancer radiotherapy
Authors: S. Xin
This study aimed to evaluate cone-beam computed tomography setup errors during cervical cancer treatment and the effects of these errors on acute radiation toxicity and treatment efficacy. A total of 170 cervical cancer patients were randomly divided into image-guided radiation therapy (IGRT; 86 patients) and intensity-modulated radiation therapy (IMRT; 8.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.4
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.4
Molecular characterization, tissue expression profile, and single nucleotide polymorphism analysis of the periostin gene in swine
Authors: D. Xu, H.M. Ma and D.F. Xiao
Periostin, also called osteoblast-specific factor 2, is an important regulator of bone, cardiac development, and wound healing. A recent study revealed that periostin plays an important role in tumor development and is upregulated in a wide variety of cancers. However, little is known about periostin in swine. Therefore, the cDNA sequence of the porcine p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017187
- DOI:
- 10.4238/gmr.15017187
Craniocervical decompression with duraplasty and cerebellar tonsillectomy as treatment for Chiari malformation-I complicated with syringomyelia
Authors: C.S. Bao, L. Liu, B. Wang, X.-G. Xia, Y.J. Gu, D.J. Li, S.L. Zhan,G.L. Chen and F.B. Yang
This study aimed to investigate the therapeutic effects of craniocervical decompression with duraplasty and cerebellar tonsillectomy for the treatment of Chiari malformation-I with syringomyelia (CM I-SM). From January 2005 to December 2011, 127 patients with CM I-SM underwent craniocervical decompression with duraplasty and cerebellar tonsillectomy and t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.2
- DOI:
- 10.4238/2015.February.3.2
Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury
Authors: X.E. Meng, Y. Zhang, N. Li, D.F. Fan, C. Yang, H. Li, D.Z. Guo and S.Y. Pan
We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model. An improved Feeney freefall method was used to establish the rat traumatic brain injury model. Sixty rats were randomly divided into three groups: a sham surgery group, a traumatic brain injury g.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016933
- DOI:
- 10.4238/gmr.15016933
TLR4/NF-�ºB signaling pathway-mediated and oxLDL-induced up-regulation of LOX-1, MCP-1, and VCAM-1 expressions in human umbilical vein endothelial cells
Authors: Y. Feng, Z.R. Cai, Y. Tang, G. Hu, J. Lu3, D. He and S. Wang
This study aimed to investigate the function and signaling pathway of Toll-like receptor 4 (TLR4) in oxidized low-density lipoprotein (oxLDL)-induced up-regulated expressions of oxidized LDL receptor 1 (LOX-1), monocyte chemoattractant protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein en.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.13
- DOI:
- 10.4238/2014.January.28.13
Association between RsaI polymorphism in estrogen receptor �² gene and male infertility
Authors: B.M. Bordin and K.K.V.O. Moura
The estrogen receptor β (ERβ) gene plays an important role in the regulation of fertility in both males and females. The RsaI polymorphism in ERβ is associated with male infertility in Caucasian patients. The aim of this study was to investigate the frequency of this polymorphism in the etiology of idiopathic male infertility and its correl.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.7
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.7
Influence of interleukin-1�² and interleukin-6 gene polymorphisms on the development of acute pancreatitis
Authors: D.Z. Chi, J. Chen and D.P. Huang
We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1b and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1Ã?² +3954 C/T (rs1143634) and IL-1Ã?² -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796). The geno.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.5
- DOI:
- 10.4238/2015.February.3.5
Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors
Authors: L.O. Almeida A.C. Cust�³dio G.R. Pinto M.J. Santos J.R.W. Almeida C.A. Clara J.A. Rey C. Casartelli
The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr518
- DOI:
- 10.4238/vol8-1gmr518