Human Genetics
Association between macrophage migration inhibitory factor rs1007888 and GDM
Authors: Y. Zhan, C. Li, J. Chen, S. Yu, Q. Gao, Y.P. Wang and S.G. Liu
We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genot.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.4
- DOI:
- 10.4238/2015.February.2.4
TLR4/NF-�ºB signaling pathway-mediated and oxLDL-induced up-regulation of LOX-1, MCP-1, and VCAM-1 expressions in human umbilical vein endothelial cells..
Authors: Y. Feng, Z.R. Cai, Y. Tang, G. Hu, J. Lu, D. He and S. Wang
This study aimed to investigate the function and signaling pathway of Toll-like receptor 4 (TLR4) in oxidized low-density lipoprotein (oxLDL)-induced up-regulated expressions of oxidized LDL receptor 1 (LOX-1), monocyte chemoattractant protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein en.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.13
- DOI:
- 10.4238/2014.January.28.13
A novel mutation links to von Hippel-Lindau syndrome in a Chinese family with hemangioblastoma
Authors: X.M. Fu, S.L. Zhao, J.C. Gui, Y.Q. Jiang, M.N. Shen, D.L. Su, B.J. Gu,X.Q. Wang, Q.J. Ren, X.D. Yin, W.B. Huang and X.G. Chen
Hemangioblastoma of the central nervous system occurs as sporadic tumors or as a part of von Hippel-Lindau (VHL) disease, an autosomal dominant hereditary tumor syndrome caused by a germline mutation in the VHL tumor suppressor gene. We screened a Chinese family with VHL for mutations in the VHL gene and evaluated a genetic test for diagnosing VHL disease.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.9
- DOI:
- 10.4238/2015.May.4.9
Cumulative methylation alternations of gene promoters and protein markers for diagnosis of epithelial ovarian cancer
Authors: B.L. Xing, T. Li, Z.H. Tang, L. Jiao, S.M. Ge, X. Qiang and J. OuYang
DNA methylation plays an important role in carcinogenesis and cancer development. In this study, we examined gene methylation in epithelial ovarian cancer (EOC) using cationic conjugated polymer (CCP)-based fluorescence resonance energy transfer (FRET) to evaluate the application of cumulative methylation alternations of genes associated with cancer antig.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.11
- DOI:
- 10.4238/2015.May.4.11
Clinicopathological analysis of idiopathic membranous nephropathy in young adults
Authors: Y. Wang, G.P. Wang, B.M. Li and Q.K. Chen
The aim of this study was to understand the clinicopathological features and prognosis of idiopathic membranous nephropathy (IMN) in youth. A retrospective analysis of the clinicopathological features and prognoses of pathologically confirmed IMN in 21 patients aged 15-30 years was performed. IMN was mainly characterized as nephrotic syndrome (NS), with s.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.12
- DOI:
- 10.4238/2015.May.4.12
Zhi-Long-Huo-Xue-Tong-Yu modulates mitochondrial fission through the ROCK1 pathway in mitochondrial dysfunction caused by streptozotocin-induced diabetic kidney injury
Authors: W.H. Wu, M.P. Zhang, S.J. Yang, Q. Liu, X. Bai, J.H. Qin,B. Peng, S.T. Ou, J. Liu, C.Y. Zhao, Q. Zhang, Q.D. Hu and L. Xue
Zhi-Long-Huo-Xue-Tong-Yu (ZLHXTY) is a defined mixture of 5 herbs developed by Professor S.J. Yang according to the Buyang Huanwu decoction method, which has been recorded in the Yilingaicuo. This study investigated the renoprotective effects of ZLHXTY on mitochondrial dysfunction induced by diabetic kidney injury in a diabetic rat model. Diabetes was ind.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.18
- DOI:
- 10.4238/2015.May.4.18
Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population
Authors: Y.H. Zhang, S.F. Xu, J. Zheng, H.S. Hong and L.M. Fan
We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.19
- DOI:
- 10.4238/2015.May.4.19
Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient
Authors: S. Ghafouri-Fard M.H. Modarressi
The outer dense fiber (ODF) genes encode proteins that co-assemble along the axoneme of the sperm tail. Recently, it was demonstrated that some ODF genes are aberrantly expressed in tumors, including prostate adenocarcinoma, basal cell carcinoma, and chronic myeloid lymphoma. We cloned ODF3 and ODF4 cDNA from the testis of a patient suffering from prostat.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.4.11
- DOI:
- 10.4238/2012.October.4.11
Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance
Authors: M. Zhang and S.C. Luo
The aim of this study is to analyze gene expression data to identify key genes and pathways associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) and to improve clinical treatment strategies. The gene expression data set was downloaded from Gene Expression Omnibus and included 12 chemotherapy-resistant EOC samples an.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017496
- DOI:
- 10.4238/gmr.15017496
Mitochondrial haplogroup D4 confers resistance and haplogroup B is a genetic risk factor for high-altitude pulmonary edema among Han Chinese
Authors: Y.J. Luo W.X. Gao S.Z. Li X.W. Huang Y. Chen F.Y. Liu Q.Y. Huang Y.Q. Gao
High-altitude pulmonary edema (HAPE) is a life-threatening condition caused by acute exposure to high altitude. Accumulating evidence suggests that genetic factors play an important role in the etiology of HAPE. However, conclusions from association studies have been hindered by limited sample size due to the rareness of this disease. It is known that mitoch.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.9.1
- DOI:
- 10.4238/2012.October.9.1