Human Genetics
Distribution of pathogens causing nosocomial infection in patients with bronchial asthma
Authors: W. Mao, E.H. Cui
This study aimed to analyze nosocomial respiratory infection (NRI) in patients with bronchial asthma. Among the clinical data of 575 asthmatic patients that was collected and analyzed, 52 were diagnosed with NRI. The most common gram-positive bacterial species was Streptococcus pneumoniae, which was detected in 8 patients, whe.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.3
- DOI:
- 10.4238/2015.December.8.3
CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke
Authors: H.-Q. Yan, Y. Yuan, P. Zhang, Z. Huang, L. Chang and Y.-K. Gui
The objective of this study was to explore the relationship between CYP4F2 gene polymorphism and ischemic stroke (IS) in the Han Chinese population. We performed a case-control study to genotype four single nucleotide polymorphisms (SNPs) (rs2108622, rs3093100, rs3093105, rs3093135) in the CYF4F2 gene. The genotype and haplotype distributions were compare.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.8
- DOI:
- 10.4238/2015.January.30.8
Identification of hub genes and pathways associated with retinoblastoma based on co-expression network analysis
Authors: Q.L. Wang, X. Chen, M.H. Zhang, Q.H. Shen, Z.M. Qin
The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.4
- DOI:
- 10.4238/2015.December.8.4
Cytoskeleton changes of airway smooth muscle cells in juvenile rats with airway remodeling in asthma and the RhoA/ROCK signaling pathway mechanism
Authors: B. Wei, Y.X. Shang, M. Li, J. Jiang and H. Zhang
This article aimed to investigate changes in the cytoskeleton of airway smooth muscle cells (ASMCs) in juvenile rats with airway remodeling in asthma. We further investigated the involvement of the RhoA/ROCK signaling pathway mechanism. Rat models of airway remodeling in asthma were established by antigen sensitization with ov.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.22.2
- DOI:
- 10.4238/2014.January.22.2
Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations
Authors: H.-Q. Yan, Y. Yuan, P. Zhang, Z. Huang, L. Chang and Y.-K. Gui
The aim of this study was to explore the relationship between the ApoE gene polymorphism and dietary factors with stroke and circulating lipid levels in the Chinese population. We selected 580 patients with stroke and 580 age- and gender-matched healthy controls, and examined their ApoE polymorphism genotype using the polymerase chain reaction-restriction.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.9
- DOI:
- 10.4238/2015.January.30.9
Genetic screening and evaluation for chromosomal abnormalities of infertile males in Jilin Province, China
Authors: M. Zhang, H.-T. Fan, Q.-S. Zhang, X.-Y. Wang, X. Yang, W.-J. Tian, R.W. Li
Chromosomal abnormality is the most common genetic cause of male infertility, particularly in cases of azoospermia, oligozoospermia, and recurrent spontaneous abortion. Chromosomal rearrangement may interrupt an important gene or exert position effects. The functionality of genes at specific breakpoints, perhaps with a specifi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.7
- DOI:
- 10.4238/2015.December.8.7
Molecular authentication of Gynostemma pentaphyllum through development and application of random amplification polymorphic DNA sequence-characterized amplified region marker
Authors: J. Zhou,Y.S. Wu, R.Q. Zhao, J.F. Jiang, Y. Luo, C.T. Ma, J.Y. Qian
Due to the morphological similarities of aerial parts, it is difficult to distinguish Gynostemma pentaphyllum from Cayratia japonica, which is usually an adulterant of the former. To develop a reliable method for the identification and authentication of G. pentaphyllum, a combination of random amplification polymorphic DNA (RA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.10
- DOI:
- 10.4238/2015.December.8.10
Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer
Authors: H. Yang, G. Li and W.F. Li
We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymeras.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.13
- DOI:
- 10.4238/2015.January.30.13
Intracellular survival of virulence and low-virulence strains of Vibrio parahaemolyticus in Epinephelus awoara macrophages and peripheral leukocytes
Authors: X.J. Xu, B.H. Sang, W.B. Chen, Q.P. Yan, Z.Y. Xiong, J.B. Su and W.Z. Zou
In this study, we examined the virulence factors and pathogenesis of Vibrio parahaemolyticus in Epinephelus awoara. The chemotactic motility of V. parahaemolyticus for phagocytosis and intracellular survival in fish macrophages was determined using virulence strains and low-virulence strains of V. parahaemolyticus. We found that the intracellular mean num.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.14
- DOI:
- 10.4238/2015.January.30.14
Clinical research on dendritic cell vaccines to prevent postoperative recurrence and metastasis of liver cancer
Authors: T.Y. Sun, W. Yan, C.M. Yang, L.F. Zhang, H.L. Tang, Y. Chen, H.X. Hu, X. Wei
We aimed to evaluate dendritic cell (DC) tumor vaccines for preventing liver cancer recurrence and metastasis. DCs were induced from mononuclear cells in the peripheral blood with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4), followed by sensitizatio.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.12
- DOI:
- 10.4238/2015.December.8.12