Human Genetics
Temporal and spatial expression profiles of Frizzled 3 in the ovary during the estrous cycle
Authors: S.B. Wang1,2,3, Y.P. Liu1,2, Z.H. Zhang2, Z.K. Wang2,3, Y.X. Xu3 and Z.C. Wang1,2,3
Frizzled 3 is an important receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes. However, the role of this protein during follicular development in the adult ovary is not known. The present study was designed to investigate the expression and localization of F.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017152
- DOI:
- 10.4238/gmr.15017152
Genome-wide identification and evolutionary analysis of nucleotide-binding site-encoding resistance genes in Lotus japonicus (Fabaceae)
Authors: H. Song, P.F. Wang,T.T. Li, H. Xia,S.Z. Zhao, L. Hou,C.Z. Zhao
Nucleotide-binding site (NBS) disease resistance genes play a crucial role in plant defense responses against pathogens and insect pests. Many NBS-encoding genes have been detected in Lotus japonicus, an important forage crop in many parts of the world. However, most NBS genes identified so far in L. japonicus were only partia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.16
- DOI:
- 10.4238/2015.December.7.16
Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo
Authors: M.C. Zhu,C.G. Liu, D.X. Wang,Z. Zhan
We detected autoantibodies against melanocytes in serum samples obtained from 50 patients, including 4 with HBV, with vitiligo and identified the associated membrane antigens. Heat shock protein 70 (HSP70) and anti-tyrosinase-related protein 1 (TRP-1) antibody levels were analyzed. The associated antigens in normal human melan.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.19
- DOI:
- 10.4238/2015.December.7.19
Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles
Authors: L. Dong1, K.H. Bi1, N. Huang1 and C.Y. Chen2
Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL sam.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017170
- DOI:
- 10.4238/gmr.15017170
Association of tumor necrosis factor-�± 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis
Authors: J. Cai,M.Y. Yang, N. Hou, X. Li
We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Sci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.22
- DOI:
- 10.4238/2015.December.7.22
Association between adiponectin gene T45G polymorphism and nonalcoholic fatty liver disease risk: a meta-analysis
Authors: W. Zhang1, L.Q. Zhu1, X.L. Huo2, J. Qin2 and G.Y. Yuan3
Numerous epidemiological investigations have evaluated the association between adiponectin gene T45G polymorphism and risk of nonalcoholic fatty liver disease (NAFLD). However, the results of these studies have proven to be inconsistent. Therefore, we conducted a meta-analysis to obtain a more accurate estimation of this association. Published articles we.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017190
- DOI:
- 10.4238/gmr.15017190
Detection of damage on single- or double-stranded DNA in a population exposed to arsenic in drinking water
Authors: J. JimÃ?©nez-Villarreal, D.I. Rivas-Armendariz, C.P. Pineda-Belmontes, N.D. Betancourt-MartÃ?Ânez, M.A. MacÃ?Âas-Corral, A.J. Guerra-Alanis, M.S NiÃ?±o-CastaÃ?±eda and J. MorÃ?¡n-MartÃ?Ânez
Different studies have suggested an association between arsenic (As) exposure and damage to single-stranded DNA by reactive oxygen species derived from the biotransformation of arsenic. The single strand damages are converted to double strand damage upon interaction with ultraviolet radiation. Analysis of genomic integrity is .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029241
- DOI:
- 10.4238/gmr16029241
MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer
Authors: Q.W. Li,T. Zhou, F. Wang,M. Jiang, C.B. Liu, K.R. Zhang, Q. Zhou, Z. Tian, K.W. Hu
It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using q.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.2
- DOI:
- 10.4238/2015.December.8.2
Effects of conservative laparoscopic endometrial cystectomy and use of kidney-reinforcing and blood activating traditional Chinese medicine on ovarian functions
Authors: Y.H. Huang, L. Shen, A.H. Cai and X.F. Liang
This study investigated functional changes in the ovaries of women who have had conservative laparoscopic endometrial cystectomy and the effects of traditional kidney-reinforcing and blood-activating Traditional Chinese Medicine (TCM) on ovarian function. Seventy female patients who underwent laparoscopic endometrial cystectomy were randomized into two group.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.6
- DOI:
- 10.4238/2015.January.30.6
Construction of gene/protein interaction networks for primary myelofibrosis and KEGG pathway-enrichment analysis of molecular compounds
Authors: C.G. Sun, X.J. Cao,C. Zhou, L.J. Liu, F.B. Feng, R.J. Liu, J. Zhuang,Y.J. Li
The objective of this study was the development of a gene/protein interaction network for primary myelofibrosis based on gene expression, and the enrichment analysis of KEGG pathways underlying the molecular complexes in this network. To achieve this, genes involved in primary myelofibrosis were selected from the OMIM database.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.1
- DOI:
- 10.4238/2015.December.8.1