Human Genetics
Molecular characterization, tissue expression profile, and SNP analysis of porcine SLC13A5
Authors: L.Y. Wang, J. Jiang, H.M. Ma
Solute carrier family 13 (sodium-dependent citrate transporter member 5, SLC13A5) gene has been recently found to play an important role in intramuscular fat content in pigs. In this study, the full-length cDNA of porcine SLC13A5 was obtained from the longissimus dorsi muscle of Shaziling pigs, using the rapid amplification of.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.21
- DOI:
- 10.4238/2015.December.7.21
Hemodynamic changes of unexplained syncope patients in head-up tilt test
Authors: X. Li, L.L. Liu, Y.J. Wan and R. Peng
The purpose of this study was to observe the hemodynamic changes of unexplained syncope patients in the head-up tilt test and their correlations with age and gender. Eighty-six patients with unexplained syncope were administered the basic head-up test and nitroglycerin provocation test with continuous monitoring and recording of electrocardiogram and bloo.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.4
- DOI:
- 10.4238/2015.January.30.4
Significant association between the MTHFR A1298C polymorphism and hepatocellular carcinoma risk: a meta-analysis
Authors: W. Chang, Q. Meng, J.H. Liu, L.X. Wu, Y. Chen,S.D. Chen
The A1298C polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be associated with hepatocellular carcinoma (HCC), but there are conflicting results from previous studies. The present study aimed to investigate the association between this polymorphism and the risk of HCC using a meta-analy.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.9
- DOI:
- 10.4238/2015.December.7.9
Associations between HLA-A\B\DRB1 polymorphisms and risks of vulvar lichen sclerosus or squamous cell hyperplasia of the vulva
Authors: G.L. Liu,F.L. Cao, M.Y. Zhao,J. Shi, S.H. Liu
In this study, we aimed to explore the associations between HLA-A\B\DRB1 polymorphisms and the risks of vulvar lichen sclerosus (VLS) or squamous cell hyperplasia of the vulva (SCHV) in Han Chinese women. We enrolled 76 Han Chinese women with VLS (Group A), 74 with SCHV (Group B), and 66 healthy women (control group) in this s.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.8
- DOI:
- 10.4238/2015.December.7.8
Correlation analysis between the delayed rectifier potassium channel KCNE1 (G38S) polymorphism and atrial fibrillation among the senior Uygur population in Xinjiang
Authors: N. Wugeti, G. Yu-Jun, S. Juan, A. Mahemuti
Current resources to support genetic screening among the Uygur population in Xinjiang territory for atrial fibrillation (AF) have not been well established and large-scale epidemiological analyses are needed. Using patients from the Xinjiang Uygur population as subjects, and the delayed rectifier potassium channel KCNE1 and it.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.4
- DOI:
- 10.4238/2015.December.7.4
Changes of circulating CD4+CD25+CD127low regulatory T cells in patients with acute coronary syndrome and its significance
Authors: M. Liu, L.-J. Xu, J.-X. Wu
The aim of this study was to investigate the changes of circulating CD4+CD25+CD127low regulatory T cells (Treg) in patients with acute coronary syndrome (ACS) and its significance. The experiment was divided into three groups: ACS (48 patients), stable angina pectoris (SAP) (24 patients), and normal controls (24 subjects). The.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.4
- DOI:
- 10.4238/2015.December.7.4
Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway
Authors: Y.Q. Ren,Y.B. Zhou
This study aims to investigate the effects of andrographolide (AGP) on osteoclast formation in RAW 264.7 murine macrophage cells. The effects of AGP on cell viability were determined in RAW 264.7 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The effects of AGP on osteoclast formation.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.7
- DOI:
- 10.4238/2015.December.7.7
SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population
Authors: J. Xu, J. Wang and B. Chen
In recent genome-wide association studies, variants in the SLC30A8 gene have been found to be associated with risk for type 2 diabetes. We examined a possible association of tag SNPs spanning SLC30A8 and their haplotypes with type 2 diabetes in the Chinese Han population. There were 1508 Chinese Han type 2 diabetes patients an.. Read More»
- Genet. Mol. Res. 11(2):
- dx.doi.org/2012.May.24.1
- DOI:
- dx.doi.org/10.4238/2012.May.24.1
Role of VEGF gene polymorphisms in the clinical outcome of non-small cell lung cancer
Authors: N. Chen, C.N. Ma, M. Zhao, Y.J. Zhang
This report details a study conducted to assess the role of VEGF gene polymorphisms in the prognosis of advanced non-small cell lung carcinoma (NSCLC). Samples obtained from 210 advanced NSCLC patients admitted at the Huaihe Hospital of Henan University between January 2010 and December 2011 were recruited for this study. The .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.13
- DOI:
- 10.4238/2015.December.7.13
Determination of SCN1A genetic variants in Mexican patients with refractory epilepsy and Dravet syndrome
Authors: R.E. Jim�©nez-Arredondo, A.J.L. Brambila-Tapia, F.M. Mercado-Silva, M.T. Maga�±a-Torres and L.E. Figuera
Mutations in the SCN1A gene can result in syndromes associated with epilepsy, including the Dravet syndrome (DS). However, the prevalence of such mutations in these diseases varies widely between different studies, and has not been examined in Mexican patients with epilepsy. Therefore, the objective of this study was to determ.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029405
- DOI:
- 10.4238/gmr16029405