Human Genetics
Prognostic role of microRNA-100 in patients with bladder cancer
Authors: Y.H. Cao, H.H. Zhang,H.F. Xu, Y.J. Duan, Q. Li, B. Huang
We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the K.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.6
- DOI:
- 10.4238/2015.December.7.6
Genetic diversity of native populations of Croton tetradenius Baill. using ISSR markers
Authors: C.S. Almeida-Pereira, A.V.C. Silva, R.P. Alves, R.B. Feitosa-Alcantara, M.F. Arrigoni-Blank, S.V. Alvares-Carvalho, T.S. Costa, L.A.S. White, V.S. Pinto, T.S. Sampaio and A.F. Blank
Brazil has about 300 Croton species in different types of vegetation. Croton tetradenius Baill., which is endemic to the Northeast region and predominant in the Caatinga vegetation, stands out among the several species of this genus. Considering the importance of knowing the genetic variability of a species, the objective of t.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029602
- DOI:
- 10.4238/gmr16029602
Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia
Authors: Y. Dong, Y. Pan, R. Wang,Z. Zhang, Q. Xi,R.-Z. Liu
Male infertility is mostly caused by spermatogenic failure. Currently, routine genetic analyses of unexplained azoospermia or oligozoospermia are limited to the investigation of Y chromosomal microdeletions and chromosome karyotype analyses. The aim of this study was to find spermatogenic failure genes in patients with chromos.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.17
- DOI:
- 10.4238/2015.December.7.17
Stable expression and integrated hepatitis B virus genome in a human hepatoma cell line
Authors: L.Y. Wang, Y.G. Li, K. Chen, K. Li, J.L. Qu, D.D. Qin and H. Tang
HepG2.2.15 cell is a widely used cell model for studying HBV (hepatitis B virus) in vitro. In these cells, the HBV genome is integrated in several sites of HepG2 cellular DNA. These multiple copies may have some influence on the cellular processes. We constructed a new plasmid, pSEH-Flag-HBV, and transfected it into HepG2 cell.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.3
- DOI:
- 10.4238/2012.May.18.3
Molecular cloning and mRNA expression of a hepcidin gene from the spinyhead croaker, Collichthys lucidus
Authors: C. Sang, Y. Lin, K. Jiang, F. Zhang, W. Song
Antimicrobial peptides are important components that participate in host innate immune activities and play crucial roles in host defense against microbial invasion. Hepcidin is an antimicrobial peptide and iron-regulatory molecule that primarily functions in the liver. In the present study, we first obtained a full-length cDNA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.18
- DOI:
- 10.4238/2015.December.7.18
Correlation of ERCC1 expression in peripheral blood lymphocytes with outcomes of patients with gastric cancer treated with oxaliplatin-based adjuvant chemotherapy
Authors: Y.Y. Zhang, K.S. Gu, H.Y. Wu,F. Yang, L.J. Bu, C.C. Zhao,Y.R. Zhang
Excision repair cross-complementing gene-1 (ERCC1) is a key regulatory enzyme whose expression patterns in tumor tissues are associated with survival in gastric cancer. The present study aimed to evaluate the effects of ERCC1 expression in peripheral blood lymphocytes (PBLs) on the outcome of patients with gastric cancer treat.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.3
- DOI:
- 10.4238/2015.December.7.3
Relationship between TLR4 and CCL2 expression and recurrent spontaneous abortion
Authors: P. Li1,2, H.L. Wu2 and B.H. Dong1
The increasing incidence of recurrent spontaneous abortion (RSA) severely affects women’s health. The involvement of the immune system during pregnancy and its contribution to RSA draw researchers’ attention. Both Toll-like receptor 4 (TLR4) and chemokine (C-C motif) ligand 2 (CCL2) have been linked to various pregnancy disorders. In this stud.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016882
- DOI:
- 10.4238/gmr.15016882
Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control
Authors: H.R. Frigeri, I.C.R. Santos, R.R. R�©a, A.C.R. Almeida, C.M.T. Fadel-Picheth, F.O. Pedrosa, E.M. Souza, F.G.M. Rego and G. Picheth
Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sam.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.2
- DOI:
- 10.4238/2012.May.18.2
Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia
Authors: Z. Huang, W.J. Liu, Q.L. Guo, C.Y. Liu
Platelet activation and functional changes were investigated in acute lymphoblastic leukemia (ALL) to provide the basis for early diagnosis and evaluation of curative effect. Platelet parameters, immature platelet fraction (IPF%), immature platelet count (IPC), P-selectin (CD62p) (PAC-1) expression were detected in ALL, ALL-co.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.20
- DOI:
- 10.4238/2015.December.7.20
Role of interleukin-6 polymorphisms in the development of allergic rhinitis
Authors: N. Zhao1,2, H.J. Liu2, Y.Y. Sun3 and Y.Z. Li1
The aim of this study was to investigate the role played by the IL-6 rs1800795 (-174G/C) and rs1800796 (-572G>C) polymorphisms in the susceptibility to allergic rhinitis in a Chinese population. A total of 265 patients with allergic rhinitis and 265 controls from our hospital were enrolled in this study. The IL-6 rs1800795 and rs1800796 polymorphisms w.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016987
- DOI:
- 10.4238/gmr.15016987