Human Genetics
Mechanism of pingyangmycin-induced apoptosis of cultured human umbilical vein endothelial cells
Authors: Y.D. Huang, X. Tong, Q. Chen, S.W. Xia, Y. Zhuo, Z.H. Kang and X.Y. Xue
In this study, we investigated the effects of pingyangmycin (PYM) on the growth inhibition and apoptosis of human umbilical vein endothelial cells (HUVEC). In this study, we aimed to explore the optimal concentration of PYM to induce the apoptosis of HUVEC and to determine its mechanism of action. After treatment of HUVEC with.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029298
- DOI:
- 10.4238/gmr16029298
Molecular DNA identification of medicinal plants used by traditional healers in Malaysia
Authors: N.A.A. Aziz, M.I. Ahmad, D.M. Naim
Plants have been used throughout human history for food and medicine. However, many plants are toxic, and cannot easily be morphologically distinguished from non-toxic plants. DNA identification solves this problem and is widely used. Nonetheless, plant DNA barcode identification faces a number of challenges, and many studies .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.5
- DOI:
- 10.4238/2015.December.7.5
TNF-�± G-308A polymorphism is associated with insulin resistance: a meta-analysis
Authors: H.G. Wang, J. Yang, H. Han, F. Xu, Y. Bian, H. Zhang and J.L. Wang
Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conflicting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE an.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.11
- DOI:
- 10.4238/2015.January.26.11
Study of the antimicrobial peptide indolicidin and a mutant in micelle medium by molecular dynamics simulation
Authors: C.A. Fuzo, J.R.M. Castro and L. Degr�¨ve
The antimicrobial peptide indolicidin (IND) and the mutant CP10A in hydrated micelles were studied using molecular dynamics simulations in order to observe whether the molecular dynamics and experimental data could be sufficiently correlated and a detailed description of the interaction of the antimicrobial peptides with a model of the membrane provided b.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr477
- DOI:
- 10.4238/vol7-4gmr477
Characterization and development of 56 EST-SSR markers derived from the transcriptome of Odontobutis potamophila
Authors: P.P. Wang, M. Ren, S.Q. Chen, S.W. Yin, C. Zhao, H.Y. Zhang, X.R. Li, Q.Q. Cao and G.Q. Zhou
Expressed sequence tags (ETSs) are the sources of microsatellite development. In this study, we isolated and characterized microsatellite markers for Odontobutis potamophila by using Illumina RNA-sequencing. We sequenced a large number of ESTs and screened 200 potential microsatellites. Consequen.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029129
- DOI:
- 10.4238/gmr16029129
Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis
Authors: H.Y. Cao, S. Yang, S. Wang, L.Y. Deng, J.Y. Lou
We conducted a meta-analysis to examine p16INK4a expression in uterine smooth muscle tumors (USMTs). Although the prognostic value of tumor suppressor p16INK4a has been elucidated in a variety of cancers and precancerous lesions, its role in USMTs is not well established. We searched PubMed, Web of Science, and Embase for publ.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019481We conducted a meta-analysis to examine p16INK4a expression i
- DOI:
- 10.4238/gmr16019481We conducted a meta-analysis to examine p16INK4a expression i
DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis
Authors: R.B. Ji, Y.S. Qian, A.R. Hu, Y.R. Hu
Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.11
- DOI:
- 10.4238/2015.December.7.11
Intraspecific differentiation of Hancornia speciosa revealed by simple sequence repeat and random amplified polymorphic DNA markers
Authors: C.A. Nogueira, N.B. Stafuzza,T.P. Ribeiro, A.D.L. Prado, I.P.P. Meneze, N. Peixoto, P.J. Gon�§alves,L.M. Almeida
Hancornia speciosa, popularly known as mangabeira, is a fruit tree native to the Brazilian Cerrado that shows great economic potential, due to its multiple uses. Intraspecific classification of this species is difficult because it shows high morphological diversity. An early study of the species reported that there are six bot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.12
- DOI:
- 10.4238/2015.December.7.12
Association of three common single nucleotide polymorphisms of SLC7A7 with the development of glioma in a Chinese population
Authors: H. Zhang and W.J. Shi
Gliomas are brain tumors that can be seriously damaging to human health. The SLC7 family is involved in amino acid or peptide transportation. The relationship between SLC7A7 polymorphisms and the development of glioma has been reported previously by a few studies. Therefore, we performed a hospital based case-control study to .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029026
- DOI:
- 10.4238/gmr16029026
Serum miR-200c expression level as a prognostic biomarker for gastric cancer
Authors: H.-P. Zhang,F.-B. Sun, S.-J. Li
The aim of the present study was to analyze the serum expression level of microRNA-200c (miR-200c) in gastric cancer (GC) patients and to determine the relationship between this expression and clinicopathological features and survival. Serum samples were obtained from 98 patients with GC between February 2008 and January 2013... Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.2
- DOI:
- 10.4238/2015.December.7.2