Human Genetics

Effect of the IkB�?± mutant gene delivery to mesenchymal stem cells on rat chronic pancreatitis

Authors: T. Qin, C.J. Liu, H.W. Zhang, Y.F. Pan Q. Tang, J.K. Liu,Y.Z. Wang M.X. Hu and F. Xue

This study aimed to investigate the effect of inhibitors of the NF-kΒ alpha mutant gene (IkBaM) delivery to mensenchymal stem cells (MSCs) on rat chronic pancreatitis (CP). A total of 120 Sprague-Dawley rats were randomly divided into 6 groups of 20: Group A was injected with sterile saline solution, Group B was injected .. Read More»

Genet. Mol. Res. 13(1):

2014.January.21.5

DOI:

10.4238/2014.January.21.5

Increased ROS generation and SOD activity in heteroplasmic tissues of transmitochondrial mice with A3243G mitochondrial DNA mutation

Authors: J. Li1, K. Zhou2, X. Meng1, Q. Wu1, S. Li1, Y. Liu2 and J. Wang1

The mitochondrial A3243G tRNALeu(UUR) mutation associated with a variety of mitochondrial disorders results in a severe respiratory deficiency, an increase in reactive oxygen species (ROS) production and activities of anti-oxidative enzyme in vitro. However, the phenotypic implications of this mutation have not been described in vivo. Here, mitochondria c.. Read More»

Genet. Mol. Res. 7(4):

vol7-4gmr480

DOI:

10.4238/vol7-4gmr480

Mutational characterization of the P3H1/CRTAP/CypB complex in recessive osteogenesis imperfecta

Authors: C. Barbirato, M. Trancozo, M.G. Almeida, L.S. Almeida, T.O. Santos, J.C.G. Duarte,M.R.G.O. Rebou�?§as, V. Sipolatti, V.R.R. Nunes, F. Paula

Osteogenesis imperfecta (OI) is a genetic disease characterized by bone deformities and fractures. Most cases are caused by autosomal dominant mutations in the type I collagen genes COL1A1 and COL1A2; however, an increasing number of recessive mutations in other genes have been reported. The LEPRE1, CRTAP, and PPIB genes encod.. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.36

DOI:

10.4238/2015.December.1.36

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

Authors: B.F. Chen,R. Wang,Y.J. Chen,Y. Zhu, L. Ding,Y.F. Wen

Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered .. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.37

DOI:

10.4238/2015.December.1.37

Relationship between the HLA-G 14bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis

Authors: S.K. Kim, K.H. Jeong,I.J. Kang, J.H. Chung, M.K. Shin, M.H. Lee

Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to t.. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.35

DOI:

10.4238/2015.December.1.35

Role of interleukin-10 gene polymorphisms in the development of coronary artery disease in Chinese population

Authors: H.M. Xu,Y.R. Liu

The aim of this study was to investigate the association between three common SNPs (-1082A/G, -819T/C, and -592A/C) in the interleukin 10 (IL-10) gene, and the development of coronary artery disease. Between January 2013 and December 2014, 272 patients with coronary artery disease and control subjects (each) were recruited for.. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.38

DOI:

10.4238/2015.December.1.38

Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil

Authors: S.C. Soares1,4, K. Ab�?©-Sandes5,6, V.B. Nascimento Filho4, F.M.F. Nunes2 and W.A. Silva Jr.2,3

The main purpose of this research was to analyze the relation of the genetic polymorphisms frequently expressed by antigen-presenting cells, erythrocytes and malaria susceptibility/resistance with the human malaria infection cases. The sample used consisted of 23 Plasmodium vivax (Pv)- and P. falciparum (Pf)-infected patients, and 21 healthy individuals a.. Read More»

Genet. Mol. Res. 7(4):

vol7-4gmr439

DOI:

10.4238/vol7-4gmr439

High altitude pulmonary edema and hypoxia-related genes - Genet. Mol. Res. 14 (3): 11562-11572 â�?�?Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edemaâ�?

Authors: G. Sikri, S. Dua

Genet. Mol. Res. 14(4):

2015.December.3.3

DOI:

10.4238/2015.December.3.3

FGF4 and HGF promote differentiation of mouse bone marrow mesenchymal stem cells into hepatocytes via the MAPK pathway

Authors: T. Lu, C. Yang, H. Sun, J. Lv1, F. Zhang and X.J. Dong

Our research demonstrated the potential for mouse bone marrow mesenchymal stem cells (mBMMSCs) to differentiate into hepatocytes in vitro and in vivo. However, the exact mechanism of this process remains unknown. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) cell-signaling pathway in th.. Read More»

Genet. Mol. Res. 13(1):

2014.January.21.9

DOI:

10.4238/2014.January.21.9

Backcross assisted by microsatellite markers in common bean

Authors: L.K. Oliveira1,3, L.C. Melo2, C. Brondani3, M.J.D. Peloso2 and R.P.V. Brondani3

The objectives of the present study were to monitor the effect of backcrossing through microsatellite markers and to compare different marker assisted selection strategies. Four populations were developed using donor parents resistant to the bean golden mosaic virus and, for all crosses, only individuals resistant to the bean golden mosaic virus were back.. Read More»

Genet. Mol. Res. 7(4):