Human Genetics
Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray
Authors: F.H. Bai, N.J. Wang, J. Wang, L. Yang, F.M. Zhang, F. Yin, J. Liang, K.C. Wu and D.M. Fan
With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared f.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.25.1
- DOI:
- 10.4238/2012.June.25.1
Role of fibroblast growth factor-23 in the pathogenesis of atherosclerosis in peritoneal dialysis patients
Authors: Y. Zeng, S. Feng, O.Y. Han, H.Y. Shen, D.H. Jin and Y.B. Shi
Several previous studies have demonstrated that elevated levels of fibroblast growth factor-23 (FGF-23) may be involved in atherosclerosis and contribute to the high mortality rate of peritoneal dialysis (PD) patients. The aim of this study was to determine the precise role of FGF-23 in the pathogenesis of atherosclerosis in PD patients. Between April 200.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.15
- DOI:
- 10.4238/2015.January.30.15
Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma
Authors: J.Y. Wang, A.L. Wang, W. Han, Z.L. Mu
Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and modulates the function of other neurotransmitters. Allergic inflammation triggers neuronal dysfunction and structural changes in the airways. Genetic polymorphisms in functional regions of the BDNF gene have a plausible role in modulating the risk of chi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.13
- DOI:
- 10.4238/2015.December.8.13
Ovine prion protein genotype frequencies in northwestern China
Authors: C.-L. Zhao, R. Wu, L. Liu, F.-D. Li, X.-L. Zhang, C. Wang, F. Wang, X.-L. Diao, H.-W. Guan, X. Wang and L. Zhou
Anti-scrapie breeding programs have been initiated to screen for scrapie-resistant sheep based on ovine prion protein gene (PRNP) genotypes at codons 136, 154 and 171 in many countries, especially European Union member states. However, investigation of sheep PRNP genotypes is limited in China, despite the large number of sheep.. Read More»
- Genet. Mol. Res. 11(2):
- dx.doi.org/2012.June.21.2
- DOI:
- dx.doi.org/10.4238/2012.June.21.2
MKL1-184C>T gene polymorphism is associated with coronary artery diseasein the Chinese Han population
Authors: Y. Xu B. Li, Y.-Z. Bao, X.-Y. Zhang, Z.-Y. Zhu, X.-F. Zhao,Y.-N. Shi, D. Li, S.-H. Chen, Y. Guo and C.-H. Cui
We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distr.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.4
- DOI:
- 10.4238/2014.January.28.4
Expression and significance of miR-21 in multiple myeloma patients
Authors: J.H. Wang, W.W. Zhou, B.X. Liu, D.L. Man1, Z.D. Yang, F.R. Liu and H. Shang
The aim of the present study is to examine the expression level of peripheral mir-21 in multiple myeloma (MM) patients and to determine its clinical significance. MM patients (30), monoclonal gammopathy of undetermined significance (MGUS) patients (14), and normal controls (20) were recruited to determine the serum level of β2-MG, IgA and IgM, IgG, &.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016892
- DOI:
- 10.4238/gmr.15016892
New cytogenetic aberrations found in a case of aggressive retinoblastoma
Authors: J.E.X.S. Barros, E.M. Soares-Ventura, N. Santos, B.A.S. Amaral, F.M. Oliveira, R.S. Vera Cruz, V.L.L. Morais, T.J. Marques-Salles and M.T.C. Muniz
We describe a case of retinoblastoma with an atypical presentation and previously unreported cytogenetic aberrations. A 19-month-old girl with left intraocular retinoblastoma was treated with enucleation and chemotherapy. The disease showed aggressive evolution within a short period between diagnosis and relapse. Eight months .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.16
- DOI:
- 10.4238/2012.June.15.16
CAMK4 gene variation is associated with hypertension in a Uygur population
Authors: S.Z. Chen1,2, Z. Wang1,2, L.N. Zhang1, G.L. Lu2, C.M. Zhou1, D.W. Wang1,Z.M. Tang3, L. Wang2, L. Qin2 and Z.H. Zhai2
Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ethnic groups. We studied 1224 patients with hypertension and 967 normotensive controls classified into three ethnic groups.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017207
- DOI:
- 10.4238/gmr.15017207
Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer
Authors: F.Q. Li, B. Xu, Y.J. Wu Z.L. Yang and J.J. Qian
Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.17
- DOI:
- 10.4238/2015.January.30.17
Association of IL-18 polymorphisms with rheumatoid arthritis: a meta-analysis
Authors: L.L. Li1, X.F. Deng2, J.P. Li3, N. Ning1, X.L. Hou1 and J.L. Chen1
Interleukin-18 (IL-18), an important proinflammatory cytokine, has been reported to play a potential pathological role in rheumatoid arthritis (RA). Results from previous studies on the association between IL-18 polymorphisms and RA are conflicting. To clarify this, an updated meta-analysis of all available studies on IL-18 polymorphisms and RA was conduc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017389
- DOI:
- 10.4238/gmr.15017389