Human Genetics
Correlation-based linear discriminant classification for gene expression data
Authors: M. Pan and J. Zhang
Microarray gene expression technology provides a systematic approach to patient classification. However, microarray data pose a great computational challenge owing to their large dimensionality, small sample sizes, and potential correlations among genes. A recent study has shown that gene-gene correlations have a positive effe.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019357
- DOI:
- 10.4238/gmr16019357
Genetic variability of XRCC1 influences the treatment outcome of gastric cancer
Authors: H.Q. Hu1, F. Wang2, X. Du2, X.Z. Zhao2, Z. Jin2 and M.X. Hou2
We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017452
- DOI:
- 10.4238/gmr.15017452
P2X7 receptor in the hippocampus is involved in gp120-induced cognitive dysfunction
Authors: Y. Liu, G.Q. Chen, B.Y. Liu, Q. Chen, Y.M. Qian, S.S. Qin, C.L. Liu and C.S. Xu
To investigate the role of the P2X7 receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water m.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019356
- DOI:
- 10.4238/gmr16019356
Identification of molecular markers in patients with hypertensive heart disease accompanied with coronary artery disease
Authors: H. Pang, B. Han, Z.Y. Li and Q. Fu
We investigated the plasma hypersensitive C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), and apelin levels in patients with hypertensive heart disease (HHD) plus coronary artery disease (CAD). Patients with hypertension hospitalized in Xuzhou Central Hospital were categorized into the HHD group and the HHD plus CAD group; 40 healt.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.12
- DOI:
- 10.4238/2015.January.15.12
Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer
Authors: M.A. Rosales-Reynoso, L.I. Wence-Chavez, A.R. Arredondo-Valdez,S. Dumois-Petersen, P. Barros-NÃ?ºÃ?±ez, M.P. Gallegos-Arreola, S.E. Flores-MartÃ?Ânez and J. SÃ?¡nchez-Corona
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metab.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019324
- DOI:
- 10.4238/gmr16019324
Association of liver X receptor �± (LXR�±) gene polymorphism and ischemic stroke
Authors: H.X. Wang, K. Zhang, L. Zhao, J.W. Tang, L.Y. Gao and Z.P. Wei
We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.14
- DOI:
- 10.4238/2015.January.15.14
imDC: an ensemble learning method for imbalanced classification with miRNA data
Authors: C.Y. Wang, L.L. Hu, M.Z. Guo, X.Y. Liu and Q. Zou
Imbalances typically exist in bioinformatics and are also common in other areas. A drawback of traditional machine learning methods is the relatively little attention given to small sample classification. Thus, we developed imDC, which uses an ensemble learning concept in combination with weights and sample misclassification information to effectively cla.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.15
- DOI:
- 10.4238/2015.January.15.15
A rare case of a boy with de novo micro duplication at 5q35.2q35.3 from central Brazil
Authors: F.G. Reis, I.P. Pinto, L.B. Minasi, A.V. Melo, D.M. da C. Cunha, C.L. Ribeiro, C.C. da Silva, D. de M. Silva and A.D. da Cruz2,3,4,5
Genomic disorders are genetic diseases that are caused by rearrangements of chromosomal material via deletions, duplications, and inversions of unique genomic segments at specific regions. Such rearrangements could result from recurrent non-allelic homologous recombination between low copy repeats. In cases where the breakpoin.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019197
- DOI:
- 10.4238/gmr16019197
Mitochondria-dependent apoptogenic activity of the aqueous root extract of Croton membranaceus against human BPH-1 cells
Authors: D.K. Afriyie, G.A. Asare, K. Bugyei, J. Lin, J. Peng and Z. Hong
The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphis.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.18
- DOI:
- 10.4238/2015.January.15.18
Resistin expression in adipose tissues and its effect on glucose metabolism in rats with brain injury
Authors: R. Zhang1, Z.Y. Wang1, L.L. Zhu1, F. Wu1, D.Q. Chen1, L.F. Sun1 and Z.Q. Lu2
Resistin (RSTN) expression in subcutaneous adipose tissue, and its effect on glucose metabolism in rats with traumatic brain injury, was investigated using real-time PCR, western blots, and enzyme linked immunoassays. Our results show that the expression of RSTN mRNA (3.192 ± 0.046, 4.016 ± 0.010, 6.004 ± 0.020, 8.213 ± 0.013, .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017659
- DOI:
- 10.4238/gmr.15017659