Abstract
Association of liver X receptor �± (LXR�±) gene polymorphism and ischemic stroke
Author(s): H.X. Wang, K. Zhang, L. Zhao, J.W. Tang, L.Y. Gao and Z.P. WeiWe examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy control subjects. The chi-square test was used to analyze the genotype distribution between the 2 groups. We found that the risk of stroke in carriers with the AA + GA genotype was 2.12-fold higher than that in GG genotype carriers (odds ratio = 2.12, 95% confidence interval: 1.58-2.99, P LXRαgene was associated with the susceptibility to stroke in a Chinese population.
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