Human Genetics
Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis
Authors: Y. Liu, X.L. Song, G.L. Zhang, A.M. Peng, P.F. Fu, P. Li, M. Tan, X. Li, M. Li and C.H. Wang
The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, mult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.19
- DOI:
- 10.4238/2015.January.15.19
Array-CGH analysis in patients with intellectual disability and/or congenital malformations in Brazil
Authors: G.S. Vianna1, P.F.V. Medeiros2, A.F. Alves2, T.O. Silva2 and F.S. Jehee1
In several patients, intellectual disability and/or congenital malformation may be attributed to chromosomal changes. In this study, we conducted an array-CGH test of 200 patients from the Northeast of Brazil with intellectual disability and/or congenital malformation. Blood samples were collected from the proband and from their parents when possible. DNA.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017769
- DOI:
- 10.4238/gmr.15017769
Dopamine receptor D1 but not D3 essential for morphine-induced conditioned responses
Authors: Y.P. Wang, S.G. Wei, Y.S. Zhu, B. Zhao, X. Xun and J.H. Lai
Recent studies indicate the involvement of dopamine receptors D1 and D3 in the regulation of locomotor stimulant and conditioned responses to morphine in mice. Moreover, expression of brain-derived neurotrophic factor (BDNF) may be modulated by D1 and D3 receptor activities in the nucleus accumbens (NAc) and prefrontal cortex (PFC). However, the underlyin.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.1
- DOI:
- 10.4238/2015.January.16.1
Construction and identification of recombinant adenovirus carrying human TIMP-1shRNA geneg
Authors: Y.L. Sun, H. Xie, H.L. Lin, Q. Feng and Y. Liu
The aim of this study was to construct the recombinant adenovirus carrying human TIMP-1shRNA gene expression system for preliminary identification to lay the foundation for the further study of gene therapy. Using the Adeno-XTM system, the recombinant adenovirus plasmid pAdeno-XTM green fluorescent protein (GFP)-tissue inhibitor of metalloprotease (TIMP)-.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.3
- DOI:
- 10.4238/2015.January.16.3
Changes in gene expression profiles of bovine embryos produced in vitro, by natural ovulation, or hormonal superstimulation
Authors: T.C.D. Mundim, A.F. Ramos, R. Sartori, M.A.N. Dode, E.O. Melo, L.F.S. Gomes, R. Rumpf and M.M. Franco
Embryos produced by hormonal superstimulation have been used as an in vivo control in most published research on embryo gene expression. However, it is not known if this is the most appropriate control for gene expression profile studies. We compared the expression of GRB-10, IGF-II, IGF-IIR, MnSOD, GPX-4, catalase, BAX, and i.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr646
- DOI:
- 10.4238/vol8-4gmr646
Expression of transforming growth factor-�²1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue
Authors: F.B. Li1, H. Zhao1, K.R. Peng1, Z.G. Gao2, S.J. Huang2, J.F. Tou2, X.L. Shu3and W.Z. Gu4
We investigated the expression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in the liver tissue of infants with congenital biliary atresia and neonatal hepatitis, as well as the relationship between the expression of the two factors and liver fibrosis. Thirty-six infants who met the cholestasis criteria we.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017217
- DOI:
- 10.4238/gmr.15017217
Immunoexpression of HPV 16/18 E6 and E7 oncoproteins in high-grade cervical squamous intraepithelial lesions in HIV-positive women
Authors: L.C. Rodrigues1, N.M. de Gois Speck1, G.R. de Azevedo Focchi2, M.A. Schimidt1, R.M. Marques3 and J.C. Lascasas Ribalta1
The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excisi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017220
- DOI:
- 10.4238/gmr.15017220
Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranh�£o
Authors: S.C. Moutinho Monteiro1, I.H. de Sousa1, I.K. Pereira Belfort1,J.D. Nunes1, B.A. Sousa Penha1, M. dos Santos2, I. Drumond Louro3 and I.D.C. Guerreiro da Silva4
Inter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with N.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017275
- DOI:
- 10.4238/gmr.15017275
Protective effects of �²-carotene against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster
Authors: C.D. Dias, B.C. Ara�ºjo, E.S. Dutra and J.C. Nepomuceno
β-carotene (BC), pro-vitamin A, is an efficient antioxidant, effective in the neutralization of oxygen reactive species, which cause serious damage to DNA. Various studies have been conducted on the effectiveness of BC for chemoprevention of cancer and heart disease. Doxorubicin is a chemotherapeutic agent used for cancer.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr626
- DOI:
- 10.4238/vol8-4gmr626
Effect of pregnancy on the proliferation of rat adipose-derived stem cells
Authors: J.N. Li, Y. Zhang, Y.F. Wang and J.Y. Chen
Stem cell therapy faces many problems including poor survival rates and low viability. Enhancing the biological functions of stem cells improves efficacy of therapies. Estrogen, whose levels are elevated during pregnancy, affects the properties of bone marrow mesenchymal stem cells. Evidence suggests that adipose-derived stem .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019059
- DOI:
- 10.4238/gmr16019059