Human Genetics
Association of single nucleotide polymorphisms with carcass traits in Nellore cattle
Authors: J.B.S. Ferraz, L.F.B. Pinto, F.V. Meirelles, J.P. Eler, F.M. de Rezende, E.C.M. Oliveira, H.B. Almeida, B. Woodward4 and D. Nkrumah
The association between two single nucleotide polymorphisms (SNPs), T945M and UCP1SNP1, with hot carcass weight (HCW, kg, N = 618), longissimus dorsi muscle area (REA, cm2, N = 633), and backfat thickness (BF, mm, N = 625), measured in Nellore cattle in Brazil, was evaluated. Likelihood ratio tests were used to evaluate reduce.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr650
- DOI:
- 10.4238/vol8-4gmr650
GRK2 desensitizes flow-induced responses in osteoblasts
Authors: Y. Xing, Y. Gu, X. Shan, L. Wang and J. You
Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology. Th.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019363
- DOI:
- 10.4238/gmr16019363
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells
Authors: H. Yan, J.Y. Xia and F.Z. Feng
The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019411
- DOI:
- 10.4238/gmr16019411
Genetic association between the HLA-G 14-bp insertion/deletion polymorphism and the recurrent spontaneous abortions in Saudi Arabian women
Authors: S.Y. Al Omar, L. Mansour, A.F. Alkhuriji, S. Alwasel and S. Al-Qahtani
The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localiz.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.2
- DOI:
- 10.4238/2015.January.23.2
miR-187 induces apoptosis of SiHa cervical carcinoma cells by downregulating Bcl-2
Authors: C.Y. He and J. Yang
Cervical carcinoma is a life-threatening illness posing considerable danger to women’s health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018969
- DOI:
- 10.4238/gmr16018969
Identification of novel and useful EST-SSR markers from de novo transcriptome sequence of wheat (Triticum aestivum L.)
Authors: Z.J. Yang, Z.S. Peng and H. Yang
Simple sequence repeats (SSRs) are highly informative, polymorphic, and co-dominant Mendelian markers that provide an important genomic resource for genetic research. Recently, the use of large-scale transcriptome sequence has become a reliable and efficient approach for the identification and development of new EST-SSR markers. In this study, 8389 potent.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017509
- DOI:
- 10.4238/gmr.15017509
Three-step method for the amplification of the coxsackievirus A10 genome
Authors: A.Y. Wang1,2*, C.Y. Mu1,3*, C. Chen3, Z. Li1 and Y.H. Xu2
The whole-genome sequencing of coxsackievirus (CV)-A10 does not follow a conventional experimental protocol. To fully understand the genetic variation and evolution of CV-A10, complete genome amplification is necessary. Most previous studies have concentrated on partial sequences of the CV-A10 genome, such as the VP1 gene. The few studies that have invest.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017513
- DOI:
- 10.4238/gmr.15017513
Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer
Authors: B.C. Almeida1, J.P.F.O. Kleine1, C.M. Camargo-Kosugi1,2, M.R. Lisboa1,C.N. Fran�§a3, J.P. Fran�§a4 and I.D.C.G. Silva1
The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017055
- DOI:
- 10.4238/gmr.15017055
IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B
Authors: L.N. Cao1, S.L. Cheng2 and W. Liu3
We conducted a case-control study to assess the role of two IL10 gene polymorphisms (rs1800896 and rs1800872) in susceptibility to liver cirrhosis, and their association with chronic hepatitis B in a Chinese population. A case-control study was designed to investigate the association between functional polymorphisms of IL10 (rs1800896 and rs1800872) and t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017256
- DOI:
- 10.4238/gmr.15017256
Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis
Authors: X.N. Zhao1, Y.N. Li2 and Y.T. Wang1
Our study aimed to investigate the effects of interleukin-4 (IL-4) on macrophage polarization, as well as its role in the development of atherosclerosis. Human peripheral blood mononuclear cells (PBMCs) were isolated and randomly divided into 3 groups: control group, ox-LDL group, and ox-LDL + IL-4 groups. The expression of M1/M2 macrophage surface marker.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017348
- DOI:
- 10.4238/gmr.15017348