Human Genetics
XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people
Authors: X. Wang, K.W. Ma, Y.G. Zhao, G.J. Wang, W. Li
Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nucleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.3
- DOI:
- 10.4238/2015.December.1.3
Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure
Authors: H.Y. Duan, D.M. Liu, P. Qian, S.L. Wang, L.J. Yan, J.T. Wu, H.T. Yang, X.W. Fan, Y.J. Chu
The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.25
- DOI:
- 10.4238/2015.December.1.25
Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules
Authors: J.J. Su, L.Z. Hui, C.J. Xi and G.Q. Su
The present study was conducted to analyze the correlation between ultrasonic characteristics, pathological type, and molecular markers of thyroid-tumor-related genes as well as to evaluate the diagnosis and prognosis of thyroid nodules. The acoustic characteristics of 130 thyroid specimens were detected. Pathological sectioning and immunohistochemical de.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.2
- DOI:
- 10.4238/2015.January.15.2
Roles of peripheral B1 cells in the individualized treatment of adult idiopathic thrombocytopenic purpura
Authors: H.-Q. Luo, Y.-G. Zhong, G.-Z. Zhou, J.-P. Fu and W.-Y. Feng
The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. We also assessed the role of FYB SNPs in the insurgence of autoimmune polyglandular syndrome type III (APSIII), characterized by the sim.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.3
- DOI:
- 10.4238/2015.January.15.3
Meta-analysis demonstrates association of the TGF-�²1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations
Authors: H. Wang P. Li Z.-C. Feng
There are conflicting reports associating the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy. We investigated this association through a meta-analysis. Case-control studies were searched up to January 2012; the genotype frequencies in the control group were found to be consistent with Hardy-Weinberg equilibrium. Publication bi.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.8.8
- DOI:
- 10.4238/2013.February.8.8
FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III
Authors: C.J.C. Addobbati, J. de Azev�ªdo Silva, N.A.C. Tavares, J. Ara�ºjo, R.L. Guimar�£es, L. Brand�£o, S. Crovella and P. Sandrin-Garcia
The present study investigates the effects of electroacupuncture (EA) on urinary bladder pressure (UBP) in patients with acute gastrointestinal injury (AGI). Twenty patients with AGI admitted to the First Hospital of Jiaxing intensive care unit from December 2011 to June 2013 were evaluated. Conventional group patients (n = 10) were administered moderate .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.4
- DOI:
- 10.4238/2015.January.15.4
Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells
Authors: F.J. Ji, X.F. Tian, X.W. Liu, L.B. Fu, Y.Y. Wu, X.D. Fang,H.Y. Jin
The aim of the present study was to determine the antiproliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), la.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.7
- DOI:
- 10.4238/2015.December.1.7
Genetic tests for low- and middle-income countries: a literature review
Authors: P.E. Maltese, E. Poplavskaia, I. Malyutkina, F. Sirocco, A. Bonizzato, N. Capodicasa, S.Y. Nicoulina, A. Salmina, N. Aksutina, M. Dundar, T. Beccari, S. Cecchin and M. Bertelli
The aim of this review is to describe a series of ten genetic diseases with Mendelian inheritance pattern in people of low- or middle-income countries, which can be easily identified with simple and affordable methods. Recent information shows that although genetic diseases account for more than 10% of infant mortality in such.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019466
- DOI:
- 10.4238/gmr16019466
Electroacupuncture decreases the urinary bladder pressure in patients with acute gastrointestinal injury
Authors: H.J. Yu, J.G. Zhu, P. Shen, L.H. Shi, Y.C. Shi and F. Chen
Aseptic loosening associated with wear particle-induced inflammation is a major cause of joint implant failure. Recent studies have demonstrated the therapeutic effects of p38 mitogen-activated protein kinase (MAPK)-based therapies on chronic inflammatory diseases. The purpose of this study was to investigate whether SB203580, a p38 MAPK inhibitor, inhibi.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.5
- DOI:
- 10.4238/2015.January.15.5
Dynamics of 45S rDNA sites in the cell cycle: fragile sites and chromosomal stability in Lolium and Festuca
Authors: L.C. Rocha, G.A. Silva, F.O. Bustamante, R.A.D. Silveira,A. Mittlemann and V.H. Techio
Analyses carried out with fluorescence in situ hybridization (FISH) in C-metaphases of the Lolium-Festuca complex have shown the occurrence of spontaneous fragile sites (FSs) in 45S rDNA regions. FSs are expressed as gaps but they do not result in breaks or chromosomal fragments in these species. These gaps have high DNA conde.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019156
- DOI:
- 10.4238/gmr16019156