Human Genetics
Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han
Authors: C. Lu, Y.-J. Shen, Y.-F. Deng, C.-Y. Wang, G. Fan1, Y.-Q. Liu, S.-M. Zhao, B.-C. Zhang, Y.-R. Zhao, Z.-E. Wang, C.-Z. Zhang and Z.-M. Lu
Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese H.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.7
- DOI:
- 10.4238/2012.May.15.7
A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population
Authors: Q. Ren, B. Xu, S.Q. Chen, Y. Yang, C.Y. Wang, Y.D. Wang, X.H. Wang, L.X. Hua and M. Chen
Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.5
- DOI:
- 10.4238/2012.May.15.5
Association of GSTM1 and GSTT1 with ageing in auto repair shop workers
Authors: S.A. Eshkoor, S.J. Marashi, P. Ismail, S.A. Rahman, M. Mirinargesi, M.Y. Adon and R.V. Devan
We evaluated the possible influence of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genes on genetic damage due to occupational exposure, which contributes to accelerate ageing. This study was conducted on 120 car auto repair workshop workers exposed to occupational hazards and 120 controls .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.21.5
- DOI:
- 10.4238/2012.May.21.5
Mutations in NPHS1 in a Chinese child with congenital nephrotic syndrome
Authors: Z.H. Yu, D.J. Wang, D.C. Meng, J. Huang and X.J. Nie
Since the identification of the NPHS1 gene, which encodes nephrin, various investigators have demonstrated that the NPHS1 mutation is a frequent cause of congenital nephrotic syndrome (CNS); it is found in 98% of Finnish children with this syndrome and in 39-80% of non-Finnish cases. In China, compound heterozygous mutations i.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.6
- DOI:
- 10.4238/2012.May.18.6
A novel mutation of the MFN2 gene in a Chinese family with Charcot-Marie-Tooth disease
Authors: Y.W. Wang, W.T. Han, M. Jiang, C.X. Lu, X.F. Li, X. Zhang and J.X. Li
Charcot-Marie-Tooth (CMT) is a group of clinically and genetically heterogeneous inherited neuromuscular disorders. At present, more than 30 loci have been reported to be associated with CMT disease; point mutations in the mitofusin 2 (MFN2) gene is one of the most common causes. We studied a Chinese family with CMT disease in.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.5
- DOI:
- 10.4238/2012.May.18.5
Meta-analysis of TP73 polymorphism and cervical cancer
Authors: H. Feng, L. Sui, M. Du and Q. Wang
The aim of this study was to investigate the tumor protein p73 (TP73) G4C14-A4T14 polymorphism and to perform a meta-analysis to assess TP73 expression in cervical cancer and precancerous tissue. Articles containing data regarding TP73 status in cervical cancer patients and healthy controls were retrieved from PubMed, EMBASE, .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16016571
- DOI:
- 10.4238/gmr16016571
Relationship between lymphocyte DNA fragmentation and dose of iron oxide (Fe2O3) and silicon oxide (SiO2) nanoparticles.
Authors: J. JimÃ?©nez-Villarreal, D.I. Rivas-ArmendÃ?¡riz, R.D. Arellano PÃ?©rez-Vertti, E. Olivas CalderÃ?³n, R. GarcÃ?Âa-Garza, N.D. Betancourt-MartÃ?Ânez, L.B. Serrano-Gallardo and J. MorÃ?¡n-MartÃ?Ânez
At present, the use of nanoparticles is a controversial topic, especially when analyzing their effects in human tissues. Nanoparticles (NPs) can cause oxidative stress by increasing membrane lipids peroxidation and reactive oxygen species, and decreasing intracellular glutathione. Oxidative stress plays an important role in ce.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019206
- DOI:
- 10.4238/gmr16019206
VDAC2 involvement in the stress response pathway in Arabidopsis thaliana
Authors: Z. Liu, Q.H. Luo, G.Q. Wen, J.M. Wang, X.F. Li,Y. Yang
The voltage-dependent anion channel (VDAC) is the major transport protein in the outer membrane of mitochondria, and is involved in the formation of a permeable transition pore and metabolite transport. In this study, we explored the role of Arabidopsis thaliana VDAC2 (AtVDAC2) in the signal transduction pathway in Arabidopsis.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.1
- DOI:
- 10.4238/2015.December.1.1
A study of the association between the connexin 40 rs35594137 polymorphism and atrial fibrillation in Xinjiang Chinese Han and Uygur populations
Authors: Y. Feng, J. Sun, L. Wang, X.L. Hou
Atrial fibrillation (AF) occurrence has a known genetic component. Many reports have revealed a correlation between gene mutation and AF, involving genes related to ion channels, connexin (Cx), and those within the angiotensin system. In this study, the correlation between the Cx 40 polymorphism (rs35594137) and AF was in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.22
- DOI:
- 10.4238/2015.December.1.22
Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle
Authors: J. Wu, J.Y. Bai, L. Li, S. Huang, C.M. Li and G.L. Wang
DNA sequencing, nested polymerase chain reaction (PCR), and PCR-restriction fragment length polymorphism were used to investigate mutations in the coding regions of the bovine myeloid antimicrobial peptide-28 (BMAP-28) and mannan-binding lectin-associated serine protease-2 (MASP-2) genes in 249 Chinese Holstein dairy cows. The associations between the pol.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.1
- DOI:
- 10.4238/2015.January.15.1