Human Genetics
Genetic characterization of native and invasive Plagioscion squamosissimus (Perciformes, Sciaenidae) populations in Brazilian hydrographic basins
Authors: R.S. Panarari-Antunes1, A.J. Prioli2, S.M.A.P. Prioli2,3, H.F. J�ºlio Jr2, A.V. Oliveira2,3, C.S. Agostinho4, J.P. Silva Filho5 and L.M. Prioli2
The genetic diversity of invasive and native populations of Plagioscion squamosissimus (Heckel, 1840) from the Paraná, Parnaiba and Araguaia-Tocantins river basins was assessed by using Random Amplified Polymorphic DNA (RAPD) markers. Genetic data confirmed the hypothesis of low genetic variability within and among P. squamosissimus populations int.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.16
- DOI:
- 10.4238/2015.November.13.16
Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population
Authors: Y.K. Wei1, H.L. Ma2, Y.Z. Guo3, B.H. Yang1 and W.X. Pang3
The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the stud.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.17
- DOI:
- 10.4238/2015.November.13.17
Development of novel DNA markers for genetic analysis of grey hamsters by cross-species amplification of microsatellites
Authors: C. Wang1,2*, S.J. Zhang1*, X.Y. Du1, Y.M. Xu3, X.Y. Huo1, L.F. Liao3 and Z.W. Chen1
The grey hamster has been used in biomedical research for decades. However, effective molecular methods for evaluating the genetic structure of this species are lacking, which hinders its wider usage. In this study, we employed cross-amplification of microsatellite loci of species within the same genus by polymerase chain reaction. Loci screened included .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.19
- DOI:
- 10.4238/2015.November.13.19
Analysis of SNP (single nucleotide polymorphism) multiplex markers related to sudden cardiac death in Brazilian families
Authors: D.F. Braganholi1,2 and R.M.B. Cicarelli1
Sudden cardiac death (SCD) is a major public health concern worldwide, and genetic analysis may be useful in identifying the cause of death as well as in determining the possible genetic risk factors for SCD. This study analyzed eight SNPs (single nucleotide polymorphisms) highly correlated with cardiac sudden death in samples (blood and bone) from six Br.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.20
- DOI:
- 10.4238/2015.November.13.20
Effects of muscle fiber type on glycolytic potential and meat quality traits in different Tibetan pig muscles and their association with glycolysis-related gene expression
Authors: L.Y. Shen1, J. Luo1, H.G. Lei1, Y.Z. Jiang2, L. Bai1, M.Z. Li1, G.Q. Tang1, X.W. Li1, S.H. Zhang1 and L. Zhu1
The myosin heavy chain (MyHC) composition, glycolytic potential, mitochondrial content, and gene expression related to energy metabolism were analyzed in eight muscles from Tibetan pigs, to study how meat quality develops in different muscle tissues. The muscles were classified into three clusters, based on MyHC composition: masseter, trapezius, and latis.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.22
- DOI:
- 10.4238/2015.November.13.22
Analysis of the gene-protein interaction network in Analysis of the gene-protein interaction network in glioma
Authors: C. Zhou1*, W.J. Teng2*, J. Zhuang1, H.L. Liu3, S.F. Tang1, X.J. Cao4, B.N. Qin4, C.C. Wang4 and C.G. Sun1
Glioma is the most aggressive type of brain tumor. Great progress has been achieved in glioma treatment, but the protein-protein interaction networks underlining glioma are poorly understood. We identified the protein-protein interaction network for glioma based on gene expression and predicted biological pathways underlying the molecular complexes in the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.3
- DOI:
- 10.4238/2015.November.13.3
Effect of progranulin (PGRN) on the proliferation and senescence of cervical cancer cells
Authors: X.Y. Zhang1, Z.X. Pan1, H. Liu1, J.L. Yu1, G.X. Li2, H.Y. Wang3 and M.M. Liu4
We investigated the effect of progranulin (PGRN) expression on the proliferation and senescence of cervical cancer cells. PGRN small interfering RNA (siRNA) was introduced into the SiHa and HeLa cell lines of human cervical carcinoma using liposome-mediated transfection. The expression levels of PGRN in each cell line after transfection of PGRN siRNA were.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.18
- DOI:
- 10.4238/2015.November.13.18
Genetic variability and phylogeny of the 5' long terminal repeat from Brazilian bovine leukemia virus
Authors: C. Hirsch1, M.F. Camargos2, E.F. Barbosa-Stancioli3, A.A. Fonseca J�ºnior2, D.S. Raj�£o1, M.B. Heinemann1, J.K.P. Reis1 and R.C. Leite1
We conducted a phylogenetic analysis of 22 strains of bovine leukemia virus obtained by polymerase chain reaction to amplify a 582-base pair fragment of the transcriptional regulatory region 5' long terminal repeat (LTR). Twenty-two samples of proviral DNA from peripheral blood mononuclear cells containing bovine leukemia virus from naturally infected bov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.16
- DOI:
- 10.4238/2015.November.18.16
Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome
Authors: F. Zhu1, H. Jie3, L. Lian2, L.J. Qu2, Z.C. Hou2, J.X. Zheng2, S.Y. Chen1,N. Yang2 and Y.P. Liu1
Endogenous retroviruses are regarded as ideal genetic markers for evolutionary analyses. Birds were some of the initial vertebrates found to contain endogenous retroviruses. However, few studies have investigated the presence and distribution of endogenous retroviruses in goose. In this study, we detected the avian sarcoma and leukosis virus gag gene in t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.1
- DOI:
- 10.4238/2015.November.18.1
Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted to examine the associations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and recessive, dominant, and addi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.3
- DOI:
- 10.4238/2015.November.18.3