Human Genetics
Expression of aquaporin 1 and 4 in rats with acute hypoxic lung injury and its significance
Authors: Y. Wu, C.Y. Pan, C.Z. Guo, Z.J. Dong, Q. Wu, H.M. Dong and W. Zhang
Aquaporin (AQP)-1 and AQP-4 expression in lung tissues of SD rats during high altitude hypoxic lung injury, and the relationship between AQP-1 and AQP-4 expression, and acute hypoxic lung injury was analyzed. Thirty six healthy SD rats were divided into hypoxia 1d, 2d, 3d, 5d, and 7d groups and control group (N = 6). Pathologi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.19
- DOI:
- 10.4238/2015.October.19.19
Real-time PCR evaluation of cell-free DNA subjected to various storage and shipping conditions
Authors: Q. Wang, Y. Cai, P. Brady and J.R. Vermeesch
In this study, we attempted to explore the factors affecting the yield of cell-free fetal DNA (cffDNA) obtained from maternal blood samples, including the use of different types of collection tubes, the interval between sample processing, and sample shipping under extreme weather conditions. Blood samples were drawn into K3EDT.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.23
- DOI:
- 10.4238/2015.October.19.23
Segment-specific targeting via RNA interference mediates down-regulation of OPN expression in hepatocellular carcinoma cells
Authors: F. Lin1*, C.M. Huang2*, J. Cao1, Z.H. Pei1, W.L. Gu1, S.F. Fan1, K.P. Li1 and C.M. Lin1
Osteopontin (OPN) plays an important role in the metastasis and recurrence of tumors after resection of hepatocellular carcinoma (HCC). In this study, the down-regulation effect on OPN expression in HCC cells of RNA interference (RNAi) molecules designed to target different segments of OPN was investigated to identify a more effective site for OPN knockdo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.6
- DOI:
- 10.4238/2015.November.18.6
Comparison of gene regulatory networks of benign and malignant breast cancer samples with normal samples
Authors: D.B. Chen H.J. Yang
The aim of this study was to explain the pathogenesis and deterioration process of breast cancer. Breast cancer expression profile data GSE27567 was downloaded from the Gene Expression Omnibus (GEO) database, and breast cancer-related genes were extracted from databases, including Cancer-Resource and Online Mendelian Inheritance In Man (OMIM). Next, h17 t.. Read More»
- Genet. Mol. Res. 13(4):
Alleviation of streptozotocin-induced diabetes in nude mice by stem cells derived from human first trimester umbilical cord
Authors: M. Cao, J.B. Zhang, D.D. Dong, Y. Mou, K. Li, J. Fang, Z.Y. Wang, C. Chen, J. Zhao and S.M. Yie
Cells isolated from human first trimester umbilical cord perivascular layer (hFTM-PV) tissues display the pluripotent characteristics of stem cells. In this study, we examined whether hFTM-PV cells can differentiate into islet-like clusters (ILCs) in vitro, and whether transplantation of the hFTM-PV cells with and without diff.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.18
- DOI:
- 10.4238/2015.October.16.18
Association between a functional genetic polymorphism (rs2230199) and age-related macular degeneration risk: a meta-analysis
Authors: M.X. Zhang, X.F. Zhao, Y.C. Ren, T.T. Geng, H. Yang, T. Feng, T.B. Jin and C. Chen
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies. The aim of this study was to perform a meta-analysis of all available studies on this SNP in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.24
- DOI:
- 10.4238/2015.October.16.24
Nineteen polymorphic microsatellite markers developed for Trachinotus ovatus
Authors: Z.Z. Xie, M.W. Huang, W. Xu, C. Peng, J.N. He, Z.N. Meng, Y. Zhang, S.S. Li and H.R. Lin
To evaluate the population genetic diversity of the ovate pompano, we isolated and characterized 19 microsatellite markers using a (CA)13-enriched genomic library. Polymorphism was assessed in 30 individuals from a single population collected from the Daya Bay Aquaculture Center, Guangdong, China. The number of alleles per locus ranged from 2 to 18 with a.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.13
- DOI:
- 10.4238/2014.December.12.13
Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis
Authors: T.L. Jia, H.J. Wu, H.B. Wang, W.B. Ma and B. Xing
Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the Pub.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.1
- DOI:
- 10.4238/2015.October.19.1
Presence of Mycobacterium leprae DNA and PGL-1 antigen in household contacts of leprosy patients from a hyperendemic area in Brazil
Authors: J.D. Pinho1, P.M.S. Rivas1, M.B.P. Mendes1, R.E.P. Soares1, G.C. Costa2,F.R.F. Nascimento2, M.F.L. Paiva3, D.M.C. Aquino4, I.A. Figueireido5,A.M. Santos3 and S.R.F. Pereira1
Leprosy is a highly infectious disease endemic to underdeveloped countries. In Maranhão State, Northeastern Brazil, the hyperendemic rate of 56.11 cases/100,000 inhabitants increased the necessity of better understanding the epidemiological profile of this population, particularly regarding efficient methods for evaluating individuals res.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.10
- DOI:
- 10.4238/2015.November.18.10
Correlation between polymorphisms of hypoxia-inducible factor-1�± Pro582Ser and type 2 diabetic nephropathy
Authors: Y.X. Bi*, L. Yu* and G.X. Jin
We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.13
- DOI:
- 10.4238/2015.November.18.13