Human Genetics
15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation
Authors: X.Y. Li1,2, B.L. Luo1, L.J. Wang1, W.D. Zhang2 and Z.G. Liu2
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant and anti-inflammatory genes, and it plays a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Moreover, 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) plays a protective role against oxidative stress and inflammation bot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.22
- DOI:
- 10.4238/2015.October.29.22
Analysis of regulatory T cell subsets in the peripheral blood of immunoglobulin A nephropathy (IgAN) patients
Authors: S. Yang, B. Chen, J. Shi, F. Chen, J. Zhang and Z. Sun
The aim of this study was to investigate the clinical significance of regulatory T cells (Tregs) and its subsets in immunoglobulin A nephropathy (IgAN) patients. Peripheral blood samples of 20 IgAN patients and 20 healthy individuals of similar ages were analyzed. Levels of Tregs and its subsets, namely nTregs and iTregs, were analyzed using flow cytometr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.28
- DOI:
- 10.4238/2015.October.29.28
Pyridoxal 5�-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report
Authors: M. Veeravigrom1,2, P. Damrongphol1,2, R. Ittiwut3,4, C. Ittiwut3,4,K. Suphapeetiporn3,4 and V. Shotelersuk3,4
Pyridoxal 5'-phosphate (PLP)-responsive epilepsy is a rare autosomal recessive epileptic disorder caused by deficiency of pyridox(am)-ne 5'-phosphate oxidase (PNPO). Neonatal onset seizures in PLP responsive epilepsy are usually resistant to common anticonvulsants and pyridoxine, but respond to PLP. Various PNPO mutations are associated with this disorder.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.34
- DOI:
- 10.4238/2015.October.29.34
Screening potential SSR markers of the anadromous fish Coilia nasus by de novo transcriptome analysis using Illumina sequencing
Authors: D.-A. Fang1,2, Y.-F. Zhou2, J.-R. Duan2, M.-Y. Zhang2, D.-P. Xu2, K. Liu2, P. Xu1,2* and Q. Wei3*
RNA-Seq technology has been widely applied to transcriptomics, genomics, molecular marker development, and functional gene studies. In the genome, microsatellites are simple sequence repeats (SSR) with a high degree of polymorphism that are used as DNA markers in many molecular genetic studies. Using traditional methods such as magnetic bead enr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.1
- DOI:
- 10.4238/2015.November.13.1
Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis
Authors: X.Q. Qu1*, W.J. Wang2*, S.S. Tang3, Y. Liu1 and J.L. Wang1
This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal ar.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.2
- DOI:
- 10.4238/2015.November.13.2
Identification of conserved microRNAs in peripheral blood from giant panda: expression of mammary gland-related microRNAs during late pregnancy and early lactation
Authors: C.D. Wang1,2*, K. Long1*, L. Jin1, S. Huang2, D.H. Li2, X.P. Ma3, M. Wei2, Y. Gu4, J.D. Ma1 and H. Zhang1,2
The giant panda (Ailuropoda melanoleuca) is one of the world’s most endangered mammals, and it has evolved several unusual biological and behavioral traits. During puberty, pregnancy, lactation, and involution, the mammary gland undergoes profound morphological and functional changes. A large number of microRNAs (miRNAs) have been identified to be i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.5
- DOI:
- 10.4238/2015.November.13.5
Expression and significance of myeloid differentiation factor 88 in non-small cell lung carcinoma and normal paracancerous tissues
Authors: J. Zhu, Q. Li, J. He and K. Ma
We studied the expression level of myeloid differentiation factor 88 (MyD88) in non-small cell lung carcinoma (NSCLC) and normal paracancerous tissues, to determine its relationship with clinical pathological characteristics and prognosis. In total, 82 NSCLC patients who had received surgical treatment in our hospital between September 2008 and December 2.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.7
- DOI:
- 10.4238/2015.November.13.7
Regulatory role of microRNA184 in osteosarcoma cells
Authors: G.R. Yin1,2, Q. Wang3, X.B. Zhang2 and S.J. Wang1
Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expresse.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.8
- DOI:
- 10.4238/2015.November.13.8
Eosinophil cationic protein mRNA expression in children with bronchial asthma
Authors: H.Y. Yu1, X.Y. Li2, Z.F. Cai1, L. Li3, X.Z. Shi4, H.X. Song5 and X.J. Liu1
Studies have shown that eosinophils are closely related to pathogenesis of bronchial asthma. Eosinophils release eosinophil cationic protein (ECP), which plays an important role in infection and allergic reactions. Serum ECP mRNA expression in children with bronchial asthma has not been adequately investigated. We analyzed serum ECP mRNA expression in 63 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.11
- DOI:
- 10.4238/2015.November.13.11
Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk
Authors: J. Wang*, S. Yang*, F.H. Guo, X. Mao, H. Zhou, Y.Q. Dong, Z.M. Wang andF. Luo
The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.13
- DOI:
- 10.4238/2015.November.13.13