Human Genetics
Sex differential marker FD for rapid sex identification of Litsea cubeba
Authors: Q. Wu, Y. Chen, Y. Wang and L. Lin
Litsea cubeba is an important economic tree in China. Sex identification of the species is required to reduce breeding costs. Molecular biology is an ideal method to achieve this aim because of the lack of morphological differences between male and female plants, especially at the seedling stage. Sequence-related amplified pol.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.1
- DOI:
- 10.4238/2015.October.21.1
Alternative splicing isoform of T cell factor 4K suppresses the proliferation and metastasis of non-small cell lung cancer cells
Authors: Y.C. Fan, L. Min, H. Chen and Y.L. Liu
The Wnt pathway has been implicated in the initiation, progression, and metastasis of lung cancer. T cell factor 4, a member of TCF/LEF family, acts as a transcriptional factor for Wnt pathways in lung cancer. Increasing amounts of evidence have shown that TCF-4 has multiple alternative splicing isoforms with transactivation or transrepression activity to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.20c
- DOI:
- 10.4238/2015.October.29.20c
Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle
Authors: Y.R. Zhang1, Y.K. Li1, C.Z. Fu 1, J.L. Wang1, H.B. Wang1,2 and L.S. Zan1,2
Beef cattle breeding programs focus on improving important economic traits, including growth rates, and meat quantity and quality. Molecular marker-assisted selection based on genetic variation represents a potential method for breeding genetically improved livestock with better economic traits. Smoothened (SMO) protein is a signal transducer that contrib.. Read More»
- Genet. Mol. Res. 13(4):
Genetic divergence of sugarcane varieties collected in the region of Lavras, Minas Gerais, Brazil
Authors: L.E.V. Cesar, A.T. Bruzi, J.A.R. Nunes, L.A. de B. Andrade, M.F. Lopes,L.R. Sales and M.M. Mour�£o
Genetic diversity among local accessions and varieties subsidize plant breeding programs, allowing the utilization of existing variability in plants that have already adapted to local climate conditions. An alternative to studying genetic variability is the study of diversity. The aim of this research was to study genetic diversity among sugarcane accessi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.23
- DOI:
- 10.4238/2015.October.29.23
An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk
Authors: D. Xiong1*, Y.P. Song2*, W. Xiong3 and Y.D. Liang2
KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.24
- DOI:
- 10.4238/2015.October.29.24
Effect of early vitamin D supplementation on asthma and the possible mechanisms
Authors: X. Chen1, S.Q. Rao2, B.H. Gao3 and Z.Q. Jiang1
Asthma is a chronic inflammatory disease of the airways with variable airflow obstruction and bronchial hyper-responsiveness. It is believed that Th2-derived cytokines orchestrate the asthmatic response and the maintenance of the balance of Th1/Th2 plays a crucial role in prevention of asthma. Moreover, 1,25(OH)2D3, the biologically activate form of vitam.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.35
- DOI:
- 10.4238/2015.October.29.35
Lack of association between rare mutations of the SIAE gene and rheumatoid arthritis in a Han Chinese population
Authors: D.D. Zhang1,2*, F. He3*, H.T. Liu4*, F. Hao1 and J. Zhu5
The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal con.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.38
- DOI:
- 10.4238/2015.October.29.38
Comparative study of neural differentiation of bone marrow mesenchymal stem cells by different induction methods
Authors: M.W. Mu, Z.Y. Zhao and C.G. Li
Neurogenic differentiation of bone marrow (BM) mesenchymal stem cells (MSCs) offers a new hope for patients with many neurological disorders. Several chemical inducers are employed to induce BMMSCs differentiation into nerve cells. In the present study, we compared different inducers [2-mercaptoethanol (BME), tretinoin (ATRA), dimethyl sulfoxide/butylated.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.39
- DOI:
- 10.4238/2015.October.29.39
Role of death receptors in the regulation of hepatocyte proliferation and apoptosis during rat liver regeneration
Authors: Y. Zhou1,2, J.C. Xu2, Y.F. Jia1 and C.S. Xu1
The balance between hepatocyte proliferation and apoptosis is critical for liver homeostasis during liver regeneration. We created a rat liver regeneration model by partial hepatectomy (PH) to investigate the overall mechanism that regulates the proliferation and apoptosis of hepatocytes. The Rat Genome 230 2.0 Array was used to investigate changes in the.. Read More»
- Genet. Mol. Res. 14(4):
- 0.4238/2015.October.29.26
- DOI:
- 0.4238/2015.October.29.26
Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer
Authors: Y.F. Ma*, B. Yang*, J. Li, T. Zhang, J.T. Guo, L. Chen, M. Li, J. Chu,C.Y. Liang and Y. Liu
Ras-related protein 25 (Rab25) is involved in many human malignancies. However, its role in chemotherapy response and prognosis in advanced non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the relationship between Rab25 and chemotherapy sensitivity and prognosis in NSCLC. Rab25 expression was assessed using immunohistochemist.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.19
- DOI:
- 10.4238/2015.October.29.19