Human Genetics
High methylation of the SEPT9 gene in Chinese colorectal cancer patients
Authors: X.L. Su, Y.F. Wang, S.J. Li, F. Zhang and H.W. Cui
Methylation of the septin 9 gene (SEPT9) occurs in higher frequency in colorectal cancer (CRC) compared to control samples, which suggests that SEPT9 methylation is a useful biomarker for screening CRC. However, the methylation status of SEPT9 in Chinese CRC patients is scarcely reported. In the present study, SEPT9 methylatio.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.17.5
- DOI:
- 10.4238/2014.January.17.5
Classification of colon cancer based on the expression of randomly selected genes
Authors: X.H. Tan, R. Cheng, H.P. Hu and Y.P. Bai
In order to ascertain the relationship between gene expression and colon cancer localization, a classification method based on random gene selection and a self-organizing map network is proposed. Different numbers of genes were selected randomly from 54,675 genes of 53 colon cancer patients in stage union for international can.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.6
- DOI:
- 10.4238/2015.October.19.6
Possible anticipation in familial epidermolytic palmoplantar keratoderma with the p.R163W mutation of Keratin 9
Authors: Y. Guo1, M. Shi2, Z.P. Tan3 and X.L. Shi1
Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant disease characterized by diffuse hyperkeratosis of the epidermis of the palm and sole with an erythematous margin. The Keratin 9 (KRT9) and Keratin 1 genes are responsible for EPPK. Several previous studies have focused on the genetic basis of EPPK; however, genetic anticipation has no.. Read More»
- Genet. Mol. Res. 13(4):
Thymidylate synthase enhancer region polymorphism not related to susceptibility to acute lymphoblastic leukemia in the Kashmir population
Authors: F.H. Nazki, A. Masood, M.A. Banday, A. Bhat and B.A. Ganai
Thymidylate synthase (TS) is a crucial enzyme in folate metabolism and plays a vital role in DNA synthesis and repair. The most common polymorphism in TS is a unique double (2R) or triple (3R) 28-bp tandem repeat sequence in the enhancer region of the TS gene (TSER). This genetic variation in TSER has been widely investigated .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.6
- DOI:
- 10.4238/2012.April.10.6
Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms
Authors: Y. Dong, L.L. Li, R.X. Wang, X.W. Yu, X. Yun and R.Z. Liu
The subsequent reproductive outcomes in couples with a history of recurrent pregnancy loss (RPL) associated with chromosome abnormalities or polymorphisms are generally not reported in China. Many RPL carrier couples have decided not to have children. The present study recorded the subsequent delivery, miscarriage, and unpregn.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.17.4
- DOI:
- 10.4238/2014.January.17.4
GSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancer
Authors: A.L. Oliveira, F.F. Oliveira Rodrigues, R.E. dos Santos, R.L. Rozenowicz and M. Barbosa de Melo
The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.22.9
- DOI:
- 10.4238/2014.January.22.9
Improvements in neuroelectrophysiological and rear limb functions in rats with spinal cord injury after Schwann cell transplantation in combination with a C5a receptor antagonist
Authors: S.-Q. Zhang, M.-F. Wu, C.-G. Peng, Y. Lv, D.-K. Wu, J. Liu and Q. Yang
We measured the effect of Schwann cell transplantation and complement factor 5a (C5a) receptor antagonist on nerve function recovery in rats with spinal cord injury. Experimental spinal cord injury was induced in eighty Wistar rats and these were randomly divided into four treatment groups: culture medium and saline injection .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.4
- DOI:
- 10.4238/2015.November.25.4
Establishment of a hepatocyte steatosis model using Chang liver cells
Authors: D. Yan, Q.L. Dou, Z. Wang and Y.Y. Wei
The objective of this study was to explore the experimental conditions for hepatocellular steatosis models of Chang liver cells induced by oleic acid (OA). For that, Chang liver cells were induced by different concentrations of OA for different periods. The MTT assay was used to detect hepatic cell activity, the Oil Red O stai.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.10
- DOI:
- 10.4238/2015.November.25.10
NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans
Authors: Q. Zhang, H.W. Fan, J.Z. Zhang, Y.M. Wang and H.J. Xing
Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.17
- DOI:
- 10.4238/2015.October.29.17
Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients
Authors: L.-H. Lian, T.-P. Lau, A.-S. Ching and K.-H. Chua
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes systemic damage, involving auto-reactive antibodies and over-deposition of immune complexes. Susceptibility to SLE is believed to be multifactorial, and genetics is one of the proven etiological factors; it can affect SLE development, severity and prognosi.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.2
- DOI:
- 10.4238/2012.April.10.2