Human Genetics
Effect of CDH1 gene methylation on transforming growth factor �²-induced epithelial-mesenchymal transition in alveolar epithelial cell line A549
Authors: Y.Y. Liu1, J.Y. Han2, S.C. Lin1, Z.Y. Liu1 and W.T. Jiang1
The aim of this study was to investigate the specific molecular mechanism of the transforming growth factor β (TGF-β)-induced epithelial-mesenchymal transition in a lung cancer cell line, and to provide new ideas for targeting therapy of lung cancer. A549 cells were treated with different concentrations of TGF-β and 5-aza-deoxycytidine (5-a.. Read More»
- Genet. Mol. Res. 13(4):
Proteomics comparison of the sera from multiple sclerosis patients and neuromyelitis optica patients
Authors: S.F. Jiang1, Q.Y. Lu2, S. Hu2, Y. Chen3, X.L. Liu4, Y. Yang1 and M.P. Ding1
This study aimed to identify the proteins that are differentially expressed in sera of multiple sclerosis (MS) patients, neuromyelitis optica (NMO) patients, and normal controls by using a two-dimensional gel electrophoresis (2-DE) assay. Serum samples were collected from the 3 groups, and total proteins were isolated and quantified by using the Bradford .. Read More»
- Genet. Mol. Res. 13(4):
Relationship between the TaqI B polymorphism of the cholesterol ester transfer protein gene and atrial fibrillation in Han and Kazak populations
Authors: M. Bakeyi1, M. Wulasihan1, W.H. Lu1,2, Y.C. Yang1, J. Li1, Z.Q. Liu1 and P.Y. He1
The TaqI B polymorphism in the cholesterol ester transfer protein (CETP) (B1 and B2 alleles; rs708272) is associated with changes in enzyme activity and lipid concentrations. The B1 allele of the CETP gene is a known independent risk factor for genetic susceptibility to atrial fibrillation (AF); however, little is known about this polymorphism in the mino.. Read More»
- Genet. Mol. Res. 13(4):
Successful treatment of larynx-tracheobronchial-pulmonary aspergillosis in an immunocompetent host
Authors: W.X. Qu, X.W. Feng and L. Zhao
Immunocompromised individuals are susceptible to pulmonary Aspergillus infections, whereas invasive Aspergillus infection is extremely rare in the presence of normal immunity. A case of larynx-tracheobronchial-pulmonary aspergillosis in an immunocompetent 57-year-old female host who was successfully treated with amphotericin-B and voriconazole is reported.. Read More»
- Genet. Mol. Res. 13(4):
miR-34a targets the inhibin beta B gene, promoting granulosa cell apoptosis in the porcine ovary
Authors: F. Tu, Z.X. Pan, Y. Yao, H.L. Liu, S.R. Liu, Z. Xie and Q.F. Li
During ovarian follicular growth and development, only a few follicles actually ovulate. Recently, it was found that follicular atresia is triggered by granulosa cell apoptosis, but the molecular mechanism of follicular atresia was not understood. Using flow cytometry, we found that miR-34a promotes granulosa cell apoptosis in.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.14.6
- DOI:
- 10.4238/2014.January.14.6
Comparative analysis of bilirubin in correlation to albumin between nephrotic syndrome patients and postoperative gastroparesis syndrome patients
Authors: M.H. Song, G.J. Zhu, L. Ma, G.L. Chen, D. Yang, J.H. Gong, Y.X. Xie, Y. Yan and M.C. Wang
This study aimed to disclose the potential causality of low bilirubin in patients with nephrotic syndrome (NS). Correlation analysis was carried out on total bilirubin (TBIL) to serum albumin (ALB), urine protein (Upr), and urinary microalbumin/creatinine (Umalb/cr) for three groups in a case-control study. P < 0.001 was observed for TBIL, ALB, Umalb/c.. Read More»
- Genet. Mol. Res. 13(4):
Curative effect of combined lamivudine, adefovir dipivoxil, and stem cell transplantation on decompensated hepatitis B cirrhosis
Authors: L. Liu1*, Y. Yan2*, J. Zhou1, L.W. Huang1, C.P. He1, K. Ling1, H.C. Zhou1, Q.M. Wen1 and X.M. Wang1
This study assessed the clinical efficacy of lamivudine and adefovir dipivoxil combined with autologous bone marrow stem cell transplantation as treatment for patients with hepatitis B and decompensated liver cirrhosis. In total, 77 patients with hepatitis B and decompensated liver cirrhosis were randomly divided into two groups. Under general symptomatic.. Read More»
- Genet. Mol. Res. 13(4):
Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population
Authors: G.S. Lordelo, A.L. Miranda-Vilela, A.K. Akimoto, P.C.Z. Alves, C.O. Hiragi, A. Nonino, M.B. Daldegan, M.N. Klautau-Guimar�£es and C.K. Grisolia
Chronic myeloid leukemia is a hematopoietic stem cell disorder that causes uncontrolled proliferation of white blood cells. Although the clinical and biological aspects are well documented, little is known about individual susceptibility to this disease. We conducted a case-control study analyzing the prevalence of the polymor.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.19.6
- DOI:
- 10.4238/2012.April.19.6
Cryopreservation does not alter karyotype, multipotency, or NANOG/SOX2 gene expression of amniotic fluid mesenchymal stem cells
Authors: P.C. Ã?Â?ngelo, A.C.S. Ferreira, V.D. Fonseca, S.P. Frade, C.S. Ferreira, F.S.V. Malta, A.K. Pereira, H.V. Leite, A.P. Brum, V.C. Pardini, K.B. Gomes and A.C.V. Cabral
Cryopreservation of mesenchymal stem cells from amniotic fluid is of clinical importance, as these cells can be harvested during the prenatal period and stored for use in treatments. We examined the behavior of mesenchymal stem cells from human amniotic fluid in culture that had been subjected to cryopreservation. We assessed .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.19.5
- DOI:
- 10.4238/2012.April.19.5
Prevalence and risk factors of overweight and obesity among individuals over 40 years old in Luzhou city
Authors: J. Zeng, Q. Wan, X. Bai, X.Z. Li, F. Liu, C. Li, X.Y. Liu and Y. Wang
In this study, a survey was conducted through questionnaire distribution and physical examinations were performed in 10,150 residents that were over 40 years old in Luzhou city. Respondents were selected by the multi-stage sampling method. The mean body mass index (BMI) of the sample population was 23.9 ± 3.3 kg/m2. Among men, BMI showed a negative.. Read More»
- Genet. Mol. Res. 13(4):