Human Genetics
Effects of stathmin 1 silencing by siRNA on sensitivity of esophageal cancer cells Eca-109 to paclitaxel
Authors: H.W. Zhu, D. Jiang, Z.Y. Xie, M.H. Zhou, D.Y. Sun and Y.G. Zhao
We investigated the effects of stathmin 1 (STMN1) silencing by small interfering (siRNA) on the sensitivity of esophageal cancer cells Eca-109 to paclitaxel. STMN1 siRNA was transiently transfected into Eca-109 cells. The effects of transfection were detected by quantitative polymerase chain reaction and western blotting. The effects of STMN1 silencing by.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.18
- DOI:
- 10.4238/2015.December.28.18
Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways
Authors: L.M. Wen, W.Z. Wu and X.C. Peng
This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from backgroun.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028343
- DOI:
- 10.4238/gmr.15028343
Selecting the optimum conditions for two-dimensional difference gel electrophoresis of proteins expressed in Populus euphratica
Authors: J.Q. Hao, N. Yue and C.X. Zheng
We selected the optimum conditions for two-dimensional difference gel electrophoresis (2D-DIGE) of proteins expressed in the heteromorphic leaves of Populus euphratica Oliv. by adjusting the isoelectric focusing, the loading quantity, the concentration of the electrophoretic gel, and other parameters. The results of our study .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028360
- DOI:
- 10.4238/gmr.15028360
Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions
Authors: M. Jargosch, S. Kr�¶ger, E. Gralinska, U. Klotz, Z. Fang, W. Chen, U. Leser, J. Selbig, D. Groth and R. Baumgrass
Data integration has become a useful strategy for uncovering new insights into complex biological networks. We studied whether this approach can help to delineate the signal transducer and activator of transcription 6 (STAT6)-mediated transcriptional network driving T helper (Th) 2 cell fate decisions. To this end, we performe.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028493
- DOI:
- 10.4238/gmr.15028493
miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-�ºB pathway
Authors: Z.W. Wu, Y.F. Liu, S. Wang and B. Li
The aim of this study was to investigate the role of miRNA-146a in modulating the function of vascular smooth muscle cells in a rat model of coronary heart disease. Vascular smooth muscle cells were isolated and cultured from the rat coronary heart disease model and normal rats (controls). miRNA-146a levels were measured in vascular smooth muscle cells ob.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.19
- DOI:
- 10.4238/2015.December.28.19
Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes
Authors: Y. Yang, Y. Zhou, S. Cheng, J.L. Sun, H. Yao and L. Ma
Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured in vitro were treated with varying concentrations of UA. The change in apoptotic activity was detected by flow cytometry. The DNA damage index 8-hydroxy-deoxy-guanosine (8-OHdG) and mitochondrial function indices succinate dehyd.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028644
- DOI:
- 10.4238/gmr.15028644
Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis
Authors: X.S. Shi, J. Li, R.H. Yang, G.R. Zhao, H.P. Zhou, W.X. Zeng and M. Zhou
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a potential cancer biomarker, yet the mechanism by which it influences the development of cancer remains unknown. In this study, we aimed to correlate MALAT1 expression with pathological features and prognosis in cancer patients. Several databases were searched using co.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.30
- DOI:
- 10.4238/2015.December.28.30
Association between TAP1 gene polymorphisms and alopecia areata in a Korean population
Authors: H.K. Kim, H. Lee, B.L. Lew, W.Y. Sim, Y.O. Kim, S.W. Lee, S. Lee, I.K. Cho, J.T. Kwon and H.J. Kim
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alope.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.31
- DOI:
- 10.4238/2015.December.28.31
Molecular identification of Achyranthis Bidentatae Radix by using DNA barcoding
Authors: D.-Y. Hou, G.-P. Wang, L.-H. Zhi, H.-W. Xu, H.-L. Liang, M.-M. Yang and G.-A. Shi
Achyranthis Bidentatae Radix has a long history in China as a commonly used herb that can be used to treat various diseases, including those related to the liver, muscles, bones, and kidneys. Recently, an increase in the number of adulterants has been reported, which affects the clinical safety of Achyranthis Bidentatae Radix... Read More»
- Genet. Mol. Res. 15(2):
Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis
Authors: B. Zhu, L. Yin and J.Y. Zhang
The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patien.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.34
- DOI:
- 10.4238/2015.December.28.34