Human Genetics
Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts
Authors: S.S. Ma, Z. Zhang, H.C. Xia, L. Chen, Y.H. Yang, Q. Yao and K.P. Chen
Baculovirus is the only virus that has been found to encode the ubiquitin protein. In this study, ubiquitin sequences from 16 insects and 49 viruses were collected and compared. The resulting sequences were aligned with virus genomes. Then MAGE 5.0, k-estimated software, as well as other software programs were used for systemic evolutionary, selection pre.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.2
- DOI:
- 10.4238/2015.August.21.2
Genetic diversity among different physiological traits of Sorghum bicolor cultivars of subtropical origin
Authors: S.O. Bafeel
The genetic diversity of Saudi locally growing sorghum (Sorghum bicolor) cultivars has not been thoroughly characterized. To understand the genomic patterns of diversification in Saudi sorghum cultivars (N = 7), random amplified polymorphic DNA (RAPD) was used as a rapid, inexpensive method for providing information regarding genomic variability below the.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.3
- DOI:
- 10.4238/2015.August.21.3
PI3K-AKT pathway polymerase chain reaction (PCR) array analysis of epilepsy induced by type II focal cortical dysplasia
Authors: Y.X. Lin, K. Lin, X.X. Liu, D.Z. Kang, Z.X. Ye, X.F. Wang, S.F. Zheng, L.H. Yu and Z.Y. Lin
The aims of this study were to observe the differential expression of PI3K-AKT pathway-related genes in seizure-inducing brain lesions in type II focal cortical dysplasia, and to explore the relationship between gene expression and histological changes in dysplastic foci and their epileptogenic mechanism. Typical lesions in brain tissue from three patient.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.5
- DOI:
- 10.4238/2015.August.21.5
Effects of microwave ablation or its combination with whole-body chemotherapy on serum vascular endothelial growth factor levels in patients with stage IIIB/IV NSCLC
Authors: Y.H. Sun, P.Y. Song, Y. Guo, M. Pang, W.-N. He, W.H. Zhang and L.J. Sheng
We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy su.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.8
- DOI:
- 10.4238/2015.August.21.8
Analysis of the relationship between peripheral blood T lymphocyte subsets and HCV RNA levels in patients with chronic hepatitis C.
Authors: Y. Huang, M.J. Zheng and Y.H. Xu
We investigated the relationship between peripheral blood T lymphocyte subsets and hepatitis C virus (HCV) RNA levels in patients with hepatitis C. Samples from 69 chronic hepatitis C (CHC) patients and 20 healthy controls were analyzed using quantitative polymerase chain reaction (PCR) to detect HCV RNA and flow cytometry to determine the expression leve.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.12
- DOI:
- 10.4238/2015.August.21.12
Establishment of a blue light damage model of human retinal pigment epithelial cells in vitro
Authors: G. Su, S.J. Cai, X. Gong, L.L. Wang, H.H. Li and L.M. Wang
To establish a blue-light damage model of human retinal pigment epithelium (RPE). Fourth-generation human RPE cells were randomly divided into two groups. In group A, cells were exposed to blue light (2000 ± 500 lux) for 0 (control), 3, 6, 9, and 12 h, and cell culture was stopped after 12 h. In group B, cells were expo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028092
- DOI:
- 10.4238/gmr.15028092
HPRTYale proposed as a pathogenic variant for Lesch-Nyhan syndrome: a case report
Authors: E. Stur, R.S. Reis, L.P. Agostini, A.M.A. Silva-Conforti and I.D. Louro
Table of Contents | Genet. Mol. Res. 2016 (2) Research Article Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes Authors: Y. Yang Y. Zhou S. Cheng J.L. Sun H. Yao L. Ma Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured i.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028251
- DOI:
- 10.4238/gmr.15028251
Effect of SNX-2112 on proliferation of esophageal cancer cells via regulation of excision repair cross-complementing 1, epidermal growth factor receptor, and p53 expression
Authors: C.Y. Li, Y.J. Ren and Y.D. Li
SNX-2112 is a potential molecular targeted therapeutic drug against esophageal cancer (EC). However, its exact mechanism of action remains to be explained. The aim of this study was to investigate the effect of SNX-2112 on excision repair cross- complementing 1 (ERCC1), epidermal growth factor receptor (EGFR), and p53, to eluc.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028318
- DOI:
- 10.4238/gmr.15028318
Analysis and application of ATP7B gene mutations in 35 patients with hepatolenticular degeneration
Authors: Y.N. Zong and X.D. Kong
We investigated the genetic mutations involved in Wilson’s disease to improve prenatal genetic diagnosis and presymptomatic diagnosis. The polymerase chain reaction (PCR) was used to amplify the exons and exon-intron boundaries of the ATP7B gene in 35 Wilson’s disease pedigrees. The PCR products were further analyzed by Sanger sequencing. Pren.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.25
- DOI:
- 10.4238/2015.December.28.25
Ancestry analysis of locally adapted Crespa goats from southernmost Brazil
Authors: D.D. Lopes, G.P. Fern�¡ndez, M. Poli, G.R.P. Moreira, G.L. Gon�§alves and T.R.O. Freitas
Crespa goats are phenotypically similar to the Angora breed, and are traditionally reared in small, low-tech farms in southernmost Brazil. Whether they represent degenerated remnants of pure Angora goats or result from foreign breeds introduced during colonial times and recently mixed with commercial breeds is unknown. Since t.. Read More»
- Genet. Mol. Res. 15(2):