Human Genetics
Screening of basidiomycetes in submerged cultivation based on antioxidant activity
Authors: S.H. Umeo, G.P.N. Souza, P.M. Rapachi, D.M. Garcia, L.D. Paccola-Meirelles, J.S. Valle, N.B. Colauto and G.A. Linde
Submerged cultivation of medicinal basidiomycetes is a reproducible and efficient method of producing mycelia and metabolites. The antioxidant activity indicates its medicinal properties and is an important tool for basidiomycete screening. In this study, we analyzed the production of mycelial biomass and exopolysaccharides and the antioxidant activity of.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.25
- DOI:
- 10.4238/2015.August.19.25
Operational taxonomic units (OTUs) of endophytic bacteria isolated from banana cultivars in the Amazon
Authors: ?. Souza, V.B. Nogueira, J.C. Cruz, N.R. Sousa, A.R.L. Proc?³pio and G.F. Silva
Endophytic microorganisms colonize plants, inhibit the growth of pathogens (by competing for nutrients and/or space), or produce antagonistic substances. Fifty-five endophytic bacteria were isolated from the leaf tissue of the FHIA 18 banana cultivar. Genetic diversity analyses were performed using the enterobacterial repetitive intergenic consensus seque.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.28
- DOI:
- 10.4238/2015.August.19.28
miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-?ºB pathway - Genet. Mol. Res. 14 (4): 18703-18712
Authors: Z.W. Wu, Y.F. Liu, S. Wang, B. Li
-.. Read More»
- Genet. Mol. Res. 15(2):
HVSI polymorphism indicates multiple origins of mtDNA in the Hazarewal population of Northern Pakistan
Authors: N. Akbar, H. Ahmad, M.S. Nadeem, B.E. Hemphill, K. Muhammad, W. Ahmad and M. Ilyas
Mitochondrial DNA (mtDNA) is an important tool used to explore ethnogenetics and the evolutionary history of human populations. In this study, hypervariable segment I (HVSI) from mtDNA was analyzed to establish the genetic lineage of the Hazarewal populations residing in the Mansehra and Abbottabad districts of Northern Pakist.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027167
- DOI:
- 10.4238/gmr.15027167
Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population
Authors: Q. Chen, X.D. Peng, C.Q. Huang, X.Y. Hu and X.M. Zhang
In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD). This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively. A total of 296 unrel.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.39
- DOI:
- 10.4238/2015.December.23.39
Mitochondrial tRNA mutations may be infrequent in hepatocellular carcinoma patients
Authors: G. Li, Y.X. Duan, X.B. Zhang and F. Wu
Mitochondrial DNA mutations have been shown to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). In particular, genes encoding mitochondrial tRNA (mt-tRNA) are hotspots for pathogenic mutations associated with HCC. Recently, an increasing number of studies have reported the involvement of such mutatio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027665
- DOI:
- 10.4238/gmr.15027665
Evaluation of novel assays for the detection of human papilloma virus in self-collected samples for cervical cancer screening
Authors: Q. Chen, H. Du, R. Zhang, J.H. Zhao, Q.C. Hu, C. Wang, G.X. Wang, J.L. Tang and R.F. Wu
The aim of this study was to evaluate the performance of three new high-risk human papillomavirus (HPV) assays for primary cervical cancer screening, by using self-collected samples, and to identify an HPV assay that could overcome the major obstacles faced during large-scale population-based screening. Two hundred and ten wom.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027896
- DOI:
- 10.4238/gmr.15027896
Association of LT?²R gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population
Authors: S.H. Lee, S.K. Kim, K.H. Yoo, J.H. Chung and S.G. Chang
The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala).. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.9
- DOI:
- 10.4238/2015.December.28.9
Sex- and age-dependent expression of Pax7, Myf 5, MyoG, and Myostatin in yak skeletal muscles
Authors: G. Wu, J. Zhang, L. Wang, S. Xu, J. Zhou, A. Xiang and C. Yang
The aim of this study was to investigate the myogenic factor mRNA expression pattern of Pax7, Myf5, MyoG, and Myostatin mRNA at different ages, sexes, and muscle tissues of Datong yaks. The expression patterns in semimembranosus (SM), quadriceps femoris (QF), and triceps muscle of arm (TM) were detected by quantitative real-ti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028020
- DOI:
- 10.4238/gmr.15028020
Respiratory chain complex III deficiency in patients with tRNA-leu mutation
Authors: J. Jiang, X.L. Wang and Y.Y. Ma
The aim of this study was to investigate the clinical and genetic profiles of mitochondrial disease resulting from deficiencies in the respiratory chain complex III. Three patients, aged between 8 months and 12 years, were recruited for this study. The activities of mitochondrial respiratory chain complexes in the peripheral leucocytes were spectrophotome.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.12
- DOI:
- 10.4238/2015.December.28.12