Human Genetics
Increased survivin expression and its association with clinical parameters of congenital choledochal cysts
Authors: Z.G. Wu, G.X. Li, B. Wang, Z.M. Chen and Q. Feng
The aim of the current study was to investigate survivin expression in congenital choledochal cysts (CCCs), and its associations with clinical parameters of CCCs. In total, 121 children with CCCs were included in this study as the case group, and their cysts were staged according to the Todani classification system. Additional.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028032
- DOI:
- 10.4238/gmr.15028032
Development of microsatellite markers in Hagenia abyssinica (Bruce) J.F. Gmel, an endangered tropical tree of eastern Africa, using next-generation sequencing
Authors: A.W. Gichira, Z.C. Long, G.W. Hu, R.W. Gituru, Q.F. Wang and J.M. Chen
Hagenia abyssinica (Bruce) J.F. Gmel is an endangered tree species endemic to the high mountains of tropical Africa. We used Illumina paired-end technology to sequence its nuclear genome, aiming at creating the first genomic data library and developing the first set of genomic microsatellites. Seventeen microsatellite markers were validated in 24 individu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028168
- DOI:
- 10.4238/gmr.15028168
Wnt1 and SFRP1 as potential prognostic factors and therapeutic targets in cutaneous squamous cell carcinoma
Authors: Y. Halifu, J.Q. Liang, X.W. Zeng, Y. Ding, X.Y. Zhang, T.B. Jin, B. Yakeya, D. Abudu, Y.M. Zhou, X.M. Liu, F.X. Hu, L. Chai and X.J. Kang
The Wnt signaling pathway plays a key role in insurgence and progression of many different forms of cancer. Some crucial components of the Wnt pathway have been proposed to be novel targets for cancer therapy. To date, the Wnt signaling pathway has not been studied in cutaneous squamous cell carcinoma (CSCC). This study was de.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028187
- DOI:
- 10.4238/gmr.15028187
Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less
Authors: D.C. Casagrande, J.C.L. Ribalta, K.D.P.F. Leite, M. Schimidt and N.M.D.G. Speck
We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017916
- DOI:
- 10.4238/gmr.15017916
A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma
Authors: X.M. Gao
This study aimed to predict pathogenic genes of childhood asthma based on molecular interaction networks and gene expression data. Known pathogenic genes identified from the human protein-protein interaction network were denoted as seed genes, and were included in network A. We extracted sub-network B (pathogenic network), whi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028226
- DOI:
- 10.4238/gmr.15028226
Single nucleotide polymorphisms associated with carcass traits in a population of Brahman and Brahman-influenced steers
Authors: A.M. Royer, C. Shivers, D.G. Riley, M.A. Elzo and M.D. Garcia
Brahman cattle are important in tropical regions due to their ability to tolerate excessive heat and parasites. However, Brahman cattle exhibit lower carcass quality characteristics when compared to Bos taurus breeds. The objective of this study was to evaluate potential associations between single nucleotide polymorphisms (SN.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028280
- DOI:
- 10.4238/gmr.15028280
Genetic diversity of the Neotropical tree Hancornia speciosa Gomes in natural populations in Northeastern Brazil
Authors: H.J. Jimenez, L.S.S. Martins, A.V.V. Montarroyos, J.F. Silva Junior, A.L. Alzate-Marin and R.M. Moraes Filho
Mangabeira (Hancornia speciosa Gomes) is a fruit tree of the Apocynaceae family, which is native to Brazil and is a very important food resource for human populations in its areas of occurrence. Mangabeira fruit is collected as an extractive activity, and no domesticated varieties or breeding programs exist. Due to a reduction in the area of ecosystems wh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.48
- DOI:
- 10.4238/2015.December.21.48
Inducing autotetraploids in cassava using oryzalin and colchicine and their in vitro morphophysiological effects
Authors: M. de J. da S. de Carvalho, V.B. Gomes, A. da S. Souza, F.F. Aud, J.A. Santos-Serejo and E.J. Oliveira
Polyploid induction has been used for plant breeding to produce bigger and more robust plants than diploid types. The present study aimed to develop a methodology for in vitro induction of polyploidy in cassava. Apical and lateral microcuttings from the BRS Formosa variety were treated with six oryzalin concentrations for 24 and 48 h. The same methodology.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028281
- DOI:
- 10.4238/gmr.15028281
One missense mutation in exon 2 of the PAX5 gene in Iran
Authors: S. Yazdanparast, S.R. Khatami, H. Galehdari and K. Jaseb
The PAX5 gene, which encodes the B-cell specific activator protein, is one of the most important factors in determination of B-cell development. This gene is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL). For example, point mutations, deletions, as well as other gene rearrangements may lead to several forms of B-cell malig.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.1
- DOI:
- 10.4238/2015.December.22.1
Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax
Authors: Y. Wei1, F.J. Yuan, W.B. Zhou, L. Wu, L. Chen, J.J. Wang and Y.S. Zhang
Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlyin.. Read More»
- Genet. Mol. Res. 15(2):