Human Genetics
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2
Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults
Authors: R. Hannum, F.R. Godoy , A.S. da Cruz, T.C. Vieira, L.B. Minasi, D. de M. e Silva, C.C. da Silva and A.D. da Cruz
Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.7
- DOI:
- 10.4238/2015.December.22.7
PKR and HMGB1 expression and function in rheumatoid arthritis
Authors: W.J. Wang, S.J. Yin and R.Q. Rong
The pathogenesis of rheumatoid arthritis (RA) is characterized by inflammation. We aimed to examine the roles of double-stranded RNA-activated protein kinase (PKR) and high-mobility group box chromosomal protein 1 (HMGB1) in a rat model of RA. Male SD rats were divided into three groups: control, RA model, and intervention (RA model plus treatment). The m.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.11
- DOI:
- 10.4238/2015.December.22.11
Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis
Authors: H. Wang, F. Xie, Z. Hu and L. Chen
The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.14
- DOI:
- 10.4238/2015.December.22.14
Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer
Authors: P. Liu, F. Xin and C.F. Ma
Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy voluntee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.25
- DOI:
- 10.4238/2015.December.22.25
Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis
Authors: M.L. Zhi, Z.J. Liu, X.Y. Yi, L.J. Zhang and Y.X. Bao
Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.28
- DOI:
- 10.4238/2015.December.22.28
Investigation into withdrawal of entecavir after 20 months in an HBsAb-positive patient who received HBsAg allogeneic stem cell transplantation
Authors: J. Peng, W.F. Luo, B. Zhou and W.Q. Wen
Hepatitis B virus (HBV) infection of donors and recipients is not an absolute contraindication for allogeneic stem cell transplantation (allo-HSCT). We studied a patient who received allo-HSCT from an HBsAg-positive donor. The patient was administered long-term immunosuppressive therapy and treated with the oral anti-viral medication, entecavir (ETV). Dur.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.22
- DOI:
- 10.4238/2015.December.22.22
Isolation and analysis of cell-free fetal DNA from maternal peripheral blood in Chinese women
Authors: W.C. Yang, L. Zhu, Y.M. Qiu, B.X. Zhou, J.L. Cheng, C.L. Wei, H.C. Chen, L.Y. Li, X.D. Fu and J.J. Fu
Non-invasive prenatal diagnosis is used to detect the genetic material of the fetus by isolating the cell-free fetal DNA (cffDNA) from maternal peripheral blood. In order to establish an isolation method for cffDNA from maternal peripheral blood in Chinese women, the cffDNA was acquired with a two-step centrifugation using a QlAamp DNA Blood mini kit. The.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.34
- DOI:
- 10.4238/2015.December.22.34
Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study
Authors: S. Wannaiampikul, B. Phonrat, A. Tungtrongchitr, C. Limwongse, N. Chongviriyaphan, J. Santiprabhob and R. Tungtrongchitr
MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) play important roles in energy homeostasis. Severe early-onset obesity, known as monogenic obesity when it is the consequence of a mutation in a single-gene product, may result when energy homeostasis is disrupted. The purpose of our study was to screen for variations of the MC3R and MC4R g.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.35
- DOI:
- 10.4238/2015.December.22.35
High expression of HIF-2�± and its anti-radiotherapy effect in lung cancer stem cells
Authors: J.C. Sun, F. He, W. Yi, M.H. Wan, R. Li, X. Wei, R. Wu and D.L. Niu
Hypoxia-inducible factor-2 alpha (HIF-2α) has been shown to regulate cell stemness, although the expression and effects of HIF-2α in lung cancer stem cells remained unclear. This study investigated HIF-2α expression in lung cancer stem cells, as well as the relationship between HIF-2α expression and radioresistance in lung cancer c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.37
- DOI:
- 10.4238/2015.December.22.37