Human Genetics
Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells
Authors: R.F. Liu, F. Wang, Q. Wang, X.C. Zhao and K.M. Zhang
Psoriasis is an inflammatory skin disease characterized by excessive proliferation and abnormal differentiation and apoptosis of keratinocytes (KCs). Mesenchymal stem cells (MSCs) from skin lesions of psoriasis patients demonstrate abnormal cytokine secretion, which may affect KC proliferation and apoptosis. Here, we explored how MSCs from skin lesions of.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.49
- DOI:
- 10.4238/2015.December.21.49
Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine
Authors: R. Gao, D. Ma, P. Wang, J. Sun, J.S. Wang and Q. Fang
We evaluated the influence of heme oxygenase-1 (HO-1) gene inhibition in myelodysplastic syndrome (MDS) cell line SKM-1 on enhancement of the demethylating effects of decitabine on p15, and explored the possible mechanism. DNMT1 gene expression in SKM-1 cells was silenced by being transfected by a constructed siRNA with liposomes. The proliferation inhibi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.3
- DOI:
- 10.4238/2015.December.22.3
Construction and validation of metagenomic DNA libraries from landfarm soil microorganisms
Authors: T.B.A. Pessoa, S.S. de Souza, A.F. Cerqueira, R.P. Rezende, C.P. Pirovani and J.C.T. Dias
Landfarming biodegradation is a strategy used by the petrochemical industry to reduce pollutants in petroleum-contaminated soil. We constructed 2 metagenomic libraries from landfarming soil in order to determine the pathway used for mineralization of benzene and to examine protein expression of the bacteria in these soils. The DNA of landfarm soil, collec.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.28.2
- DOI:
- 10.4238/2013.June.28.2
Effect of lipoic acid combined with paclitaxel on breast cancer cells
Authors: B.J. Li, X.Y. Hao, G.H. Ren and Y. Gong
Breast cancer is the most common gynecologic tumor globally that threatens women’s health. Lipoic acid is a type of antioxidant that can alleviate oxidative stress damage. Studies showed that lipoic acid could inhibit the proliferation of tumor cells in cervical cancer and colon cancer. This paper intends to explore the combined effect of lipoic aci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.18
- DOI:
- 10.4238/2015.December.22.18
Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study
Authors: T. Hasi, L. Hao, L. Yang and X.L. Su
Mongolians are known as heavy drinkers, and they have a high incidence of essential hypertension, which may be an associated pathology. We examined a possible association of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs6.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1056
- DOI:
- 10.4238/vol10-1gmr1056
Anatomy and genetic diversity of two populations of Schinus terebinthifolius (Anacardiaceae) from the Tibagi River basin in Paran�¡, Brazil
Authors: E.A. Ruas, C.F. Ruas, P.S. Medri, C. Medri, M.E. Medri, E. Bianchini, J.A. Pimenta, L.A. Rodrigues and P.M. Ruas
Knowledge of the effects of flooding on plant survival is relevant for the efficiency of management and conservation programs. Schinus terebinthifolius is a tree of economic and ecological importance that is common in northeast Brazil. Flooding tolerance and genetic variation were investigated in two riparian populations of S... Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1028
- DOI:
- 10.4238/vol10-1gmr1028
Clinical application of high-sensitivity cardiac troponin T test in acute myocardial infarction diagnosis
Authors: J.A. Wang, Y. Qin, J. Lv, Y.F. Tian and Y.J. Dong
The aim of this study was to investigate the clinical application of a high-sensitivity cardiac troponin T (hs-cTnT) test in the diagnosis of acute myocardial infarction (AMI). Serum levels of hs-cTnT and cardiac troponin I (cTnI) were detected in 240 AMI patients and 200 healthy donors and used to plot receiver operating characteristic (ROC) curves. A cl.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.21
- DOI:
- 10.4238/2015.December.22.21
Efficacy of percutaneous radiofrequency ablation for the treatment of hepatocellular carcinoma
Authors: R.N. Zheng, Z.J. You, S.H. Lin, J. Jia, Y.M. Cai, C. Liu, S. Han and S.M. Wang
In this study, we sought to evaluate the efficacy of transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation (RFA; experimental group) versus RFA treatment (control group) in patients receiving palliative treatment for hepatocellular carcinoma. To summarize the available evidence, we used the Review Manager 5.1 software to perform a m.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.24
- DOI:
- 10.4238/2015.December.22.24
Structural modeling and analysis of dengue-mediated inhibition of interferon signaling pathway
Authors: B. Aslam,J. Ahmad,A. Ali,R.Z. Paracha,S.H.K. Tareen,S. Khusro,T. Ahmad,S.A. Muhammad,U. Niazi and V. Azevedo
Dengue virus (DENV) belongs to the family Flaviviridae and can cause major health problems worldwide, including dengue fever and dengue shock syndrome. DENV replicon in human cells inhibits interferon α and β with the help of its non-structural proteins. Non-structural protein 5 (NS5) of DENV is responsible for the proteasome-mediated degradati.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.4
Assessment of CASP gene polymorphisms in periodontal disease
Authors: S.W. Kang, S.K. Kim, J.H. Chung and J.Y. Ban
Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.33
- DOI:
- 10.4238/2015.December.22.33