Human Genetics
Increased CD56+ NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion
Authors: Y. Gao and P.L. Wang
Recurrent spontaneous abortion (RSA) is reported to be associated with immune imbalance at the maternal-fetal interface. Immune cells in the decidual tissue are involved in maintaining immune tolerance during pregnancy; however, whether natural killer (NK) and T cells are altered in unexplained RSA (URSA) remains unknown. In this study, we compared the nu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.36
- DOI:
- 10.4238/2015.December.22.36
Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma
Authors: L.Q. Zhang, S.L. Sun, W.Y. Li , Z. Feng, X.Y. Xu, Q.S. Zhuang and J. Fang
Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.19
- DOI:
- 10.4238/2015.December.23.19
Inactivation of putative PKS genes can double geldanamycin yield in Streptomyces hygroscopicus 17997
Authors: Y.H. Li, M. Li, W.Q. He, Y.G. Wang and R.G. Shao
The putative polyketide biosynthesis (PKS) genes cos10 and pg10 were inactivated by insertion of a kanamycin-resistance gene into the genome of the geldanamycin-producing strain, Streptomyces hygroscopicus 17997. The resultant inactivation were confirmed by PCR analysis. The abilities of the PKS gene inactivation strains to produce geldanamycin were compa.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.3
- DOI:
- 10.4238/2013.June.21.3
Relationships between transient elastography values and liver fibrosis in chronic liver disease patients with normal or mildly abnormal aminotransferase levels
Authors: Y.P. Zhang, Q. Zhao, Y.Z. Tao, X.R. Niu and L. Rui
This study aimed to evaluate relationships between transient elastography values and liver fibrosis in chronic liver disease patients with normal or mildly abnormal aminotransferase levels. Fifty-six patients were enrolled in the study. Transient elastography and liver biopsy were performed on the same day, and the fibrosis was staged based on the Scheuer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.4
- DOI:
- 10.4238/2015.December.23.4
Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer
Authors: D.K. Sun, L. Wang, J.M. Wang and P. Zhang
Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken from 94 consecutive patients diagnosed with bladder cancer and 60 healthy control subjects. Serum DKK-1 exp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.5
- DOI:
- 10.4238/2015.December.23.5
Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells
Authors: J.Y. Zhang and L.C. Li
Past studies have revealed the critical role of runt-related transcription factor 2 (RUNX2) in the proliferation and differentiation of mesenchymal stem cells (MSCs). This study therefore aimed to investigate the expression profile of the RUNX2 gene in human bone marrow MSCs and its biological characteristics. Bone marrow MSCs were separated from 12 patie.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.8
- DOI:
- 10.4238/2015.December.23.8
Effects of CD3McAb and rhIL-2 activated bone marrow on the killing and purging of leukemia cells
Authors: X.C. Wei, D.D. Yang, X.R. Han, Y.A. Zhao, Y.C. Li, L.J. Zhang and J.J. Wang
We investigated the roles of CD3McAb and rhIL-2 activated bone marrow in the killing and purging of leukemia cells. Cytotoxicity of activated bone marrow was detected with MTT assay. CFU-GM level in activated bone marrow and the destruction of leukemia cells were measured using the semi-solid cell culture. Immune activation markers in activated bone marro.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.16
- DOI:
- 10.4238/2015.December.23.16
Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis
Authors: C.D. Wang,D.K. Wang,P.C. Cao,Z.W. Wang,Z. Wang and Y.T. Wang
We sought to investigate the effect of nerve growth factor (NGF) expression on the formation and prognosis of cerebral aneurysms. Forty-eight cases were selected following a diagnosis of cerebral aneurysm using computed tomography angiography and surgical confirmation. Thirty-four cases of healthy deaths were also chosen. The tissue was tested for NGF exp.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.8
Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm
Authors: W.S. Liu,H.J. Geng,C.D. Wang,A.J. Li,P.C. Cao,D.K. Wang and G. Li
We sought to investigate the relationship between abnormal expression of nitric oxide synthase (NOS) and pathogenesis of cerebral aneurysm. Brain tissues were collected from 36 patients with cerebral aneurysm confirmed by computer tomography with angiography or neurosurgical therapy. The control group consisted of 25 patients of similar age who had no vas.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.9
Influence of adenosine on preservation of porcine pancreas in islet transplantation
Authors: W.Q. Song, D.Z. Fu, Y. Cheng and Y.F. Liu
Ischemia time during transplantation has greatly restricted the quality and utilization of grafts. To improve the quality of islet transplantation, adenosine was added into the University of Wisconsin (UW) pancreas perfusate to assess its effect on islet yield and function in porcine pancreas. Ten pancreata from donation after cardiac death pigs were obta.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.17
- DOI:
- 10.4238/2015.December.23.17