Human Genetics
Genetic diversity and morphological characterization of half-sib families of Heliconia bihai L., H. chartacea Lane ex Barreiros, and H. wagneriana Peterson
Authors: F.R.A. Pereira, R.M. Moraes Filho, L.S.S. Martins, A.V.V. Montarroyos and V. Loges
The Neotropical Heliconia genus contains highly diversified plants and up to 220 species have been reported from the north of Mexico to the South of Brazil. Heliconia are cultivated as ornamental garden plants and as cut flowers. All species can be propagated by seeds or vegetatively, through rhizomes. Depending on the species.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028003
- DOI:
- 10.4238/gmr.15028003
Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer
Authors: W.H. Yu, Y.X. Wang, J.Q. Guo, Y.L. Wang, J.S. Zheng and K.X. Zhu
We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.25
- DOI:
- 10.4238/2015.December.21.25
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations
Authors: P.Y. Chang, L. Qin, P. Zhao and Z.Y. Liu
Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. In this study, we investigated the association between RGS5 gene variants and hypertension in the Mongolian and Han populations. Peripheral blood was obtained from 429 unrelated Mongolian herdsmen and 416 Han farmers [including essential hyperte.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.37
- DOI:
- 10.4238/2015.December.21.37
DNA and RNA polymerase activity in a Moniliophthora perniciosa mitochondrial plasmid and self-defense against oxidative stress
Authors: B.S. Andrade, C. Villela-Dias, D.S. Gomes, F. Micheli and A. G�³es-Neto
Moniliophthora perniciosa (Stahel) Aime and Phillips-Mora is a hemibiotrophic basidiomycete (Agaricales, Tricholomataceae) that causes witches’ broom disease in cocoa (Theobroma cacao L.). This pathogen carries a stable integrated invertron-type linear plasmid in its mitochondrial genome that encodes viral-like DNA and RNA polymerases related to fun.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.3
- DOI:
- 10.4238/2013.June.13.3
Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis
Authors: X.L. Liu, Q.F. Yang and B.H. Kong
Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.1
- DOI:
- 10.4238/2013.June.13.1
Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression
Authors: H. He, J. Chen, W.P. Xie, S. Cao, H.Y. Hu, L.Q. Yang and B. Gong
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes br.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.7
- DOI:
- 10.4238/2013.January.4.7
New record and cytogenetic analysis of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) from Bahia State, Brazil
Authors: J. Oliveira, K.C.C. Alevi, E.O.L. Fonseca, O.M.F. Souza,C.G.S. Santos, M.T.V. Azeredo-Oliveira and J.A. da Rosa
This paper reports on the first occurrence of Psammolestes tertius in the Chapada Diamantina region, located in the city of Seabra, Bahia State, in northeastern Brazil. Following an active search, 24 P. tertius specimens were collected from Phacellodomus rufifrons (rufous-fronted thornbird) nests. The insects did not present a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028004
- DOI:
- 10.4238/gmr.15028004
Molecular markers located on the DGAT1, CAST, and LEPR genes and their associations with milk production and fertility traits in Holstein cattle
Authors: R. Hill, A. Canal, K. Bondioli, R. Morell and M.D. Garcia
The objective of the present study was to investigate single nucleotide polymorphisms (SNPs) located in three candidate genes previously reported to have effects on fertility and milk production traits in a population of 123 Holstein cows. The milk production traits evaluated included lifetime averages of milk yield, protein c.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017794
- DOI:
- 10.4238/gmr.15017794
APOA5 polymorphisms associated with lipid metabolism in Brazilian children and adolescents
Authors: E. De Fran�§a, D.S.B.S. Silva, T.F.C. Silva, C.L. Dornelles, J.G. Alves and C.S. Alho
Single nucleotide polymorphisms in the APOA5 gene have been studied for their association with metabolic syndrome. Thus, elucidating the effect of the mechanism involved in APOA5 gene polymorphisms on lipid metabolism is of great importance. In this study we aimed to determine the allelic and genotypic frequencies of -1131T>C, Ser19Trp, and intergenic .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017809
- DOI:
- 10.4238/gmr.15017809
A new strategy for identification of currant (Ribes nigrum L.) cultivars using RAPD markers
Authors: J. Huo, G. Yang, Y. Zhang and F. Li
We developed a new approach using RAPD fingerprints to distinguish 37 currant cultivars from northeastern China based on optimization of RAPD by choosing 11 nucleotide primers and strict screening PCR annealing temperature. We found that the manual cultivar identification diagram (MCID) approach clearly developed fingerprints from 8 different primers that.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.1
- DOI:
- 10.4238/2013.June.21.1