Human Genetics
Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis
Authors: J. Yao, Z.H. Li, Y.X. Li, R. Zhang, D.G. Zhang, Z.L. Xu, L.S. Wang and J.Y. Wang
The interleukin-18 (IL-18) gene -607 C/A polymorphism has been reported to be associated with gastrointestinal cancer, but there are conflicting results from previous studies on said topic. Therefore, the aim of this meta-analysis is to derive a more precise estimation of the association between the -607 C/A polymorphism in the IL-18 gene and gastrointest.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.15
- DOI:
- 10.4238/2015.December.14.15
GSTP1 Ile105Val and XRCC1 Arg399Gln gene polymorphisms contribute to the clinical outcome of patients with advanced non-small cell lung cancer
Authors: L. Bu, L.B. Zhang, X. Mao and P. Wang
Glutathione S-transferase P1 (GSTP1) and X-ray repair cross-complementing group 1 (XRCC1) genetic variations may influence the efficacy of chemotherapy in various cancers. We investigated the possible roles of GSTP1 Ile105Val and XRCC1 Arg194Trp, and Arg399Gln gene polymorphisms in the prognosis of advanced non-small.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027611
- DOI:
- 10.4238/gmr.15027611
Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair
Authors: B.Y. Zhang, Z. Zhao and Z. Jin
Myocarditis is a common cardiovascular disease and frequently occurs in children and teenagers. It is believed to be caused by both endogenous and exogenous factors, among which FAS/FASL gene pair-induced cell apoptosis is a major mechanism of myocardial cell injury. A previous study has detected low expression of microRNA (mi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027627
- DOI:
- 10.4238/gmr.15027627
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population
Authors: H.X. Chang, B. Zhu, J.H. Yao, J. Wu, J. Wang and W. Sun
Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017391
- DOI:
- 10.4238/gmr.15017391
A structured sparse regression method for estimating isoform expression level from multi-sample RNA-seq data
Authors: L. Zhang and X.J. Liu
With the rapid development of next-generation high-throughput sequencing technology, RNA-seq has become a standard and important technique for transcriptome analysis. For multi-sample RNA-seq data, the existing expression estimation methods usually deal with each single-RNA-seq sample, and ignore that the read distributions ar.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027670
- DOI:
- 10.4238/gmr.15027670
Effects of Danhong injection on hemodynamics and the inflammation-related NF-�ºB signaling pathway in patients with acute cerebral infarction
Authors: Y. Jiang and Y.J. Lian
The objective of the current study was to investigate effects of Danhong injection on hemodynamics, inflammatory cytokines, and the NF-κB pathway in acute cerebral infarction. In total, 246 patients with acute cerebral infarction were divided into control (N = 121) and observation (N = 125) groups based on treatment. The control group underwent conv.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.21
- DOI:
- 10.4238/2015.December.14.21
Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells
Authors: Z.H. Zhang, D.Z. Yin, X.S Pang and Z.C. Wang
Vascular endothelial growth factor (VEGF)-dependent angiogenesis plays a crucial role in corpus luteum formation and its functional maintenance in mammalian ovaries. We recently reported that activation of hypoxia-inducible factor (HIF)-1α signaling contributes to the regulation of VEGF expression in luteal cells (LCs) in response to human chorionic.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.2
- DOI:
- 10.4238/2015.December.14.2
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer
Authors: Y. An , H. Li, K.J. Wang, X.H. Liu, M.X. Qiu, Y. Liao, J.L. Huang and X.S. Wang
The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studie.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.17
- DOI:
- 10.4238/2015.December.14.17
Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis
Authors: Q. Zhao, B. Zhang, Y. Chen, M. Li, X. Zhao, H. Fan and S.M. Li
The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.20
- DOI:
- 10.4238/2015.December.14.20