Human Genetics
Genetic polymorphisms in patients with endometriosis: an analytical study in Goi�¢nia (Central West of Brazil)
Authors: K.S.F. Silva and K.K.V.O. Moura
In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028135
- DOI:
- 10.4238/gmr.15028135
PKR and HMGB1 expression and function in rheumatoid arthritis - Genet. Mol. Res.14 (4): 17864-17870
Authors: W.J. Wang, S.J. Yin and R.Q. Guo
-.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.150267861
- DOI:
- 10.4238/gmr.150267861
Effects of probucol on cultured human umbilical vein endothelial cells injured by hypoxia/reoxygenation - Genet. Mol. Res. 15 (1): gmr.15016752
Authors: Y.L. Chai, J.Z. Xu, Y.L. Zhang and G.T. Sheng
-.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.150267521
- DOI:
- 10.4238/gmr.150267521
Relationship between TBX20 gene polymorphism and congenital heart disease
Authors: X.F. Yang, Y.F. Zhang, C.F. Zhao, M.M. Liu, J.P. Si, Y.F. Fang,W.W. Xing and F.L. Wang
Congenital heart disease in children is a type of birth defect. Previous studies have suggested that the transcription factor, TBX20, is involved in the occurrence and development of congenital heart disease in children; however, the specific regulatory mechanisms are yet to be evaluated. Hence, this study aimed to evaluate th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027374
- DOI:
- 10.4238/gmr.15027374
Gene expression and enzyme activity of lipoprotein lipase correlate with intramuscular fat content in Guangxi san-huang and Arbor Acres chickens
Authors: Y.N. Huang, J. Wang, B.J. Chen, Q.Y. Jiang, Y.F. Guo, G.Q. Lan and H.S. Jiang
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. This study investigated LPL gene expression, LPL enzyme activity, and the correlation of each with intramuscular fat (IMF) in Chinese Guangxi san-huang (GXSH) and Arbor Acres (AA) chickens. The results showed that age and breed had significant effects on LPL express.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027414
- DOI:
- 10.4238/gmr.15027414
Expression and prognostic influence of NF-�ºB and EGFR in esophageal cancer
Authors: Y.Q. Zhang, J.J. Zhang , H.J. Song and D.W. Li
The goal of this study was to investigate the expression profiles of nuclear factor-kappa B (NF-κB) and epidermal growth factor receptor (EGFR) in esophageal cancer and to determine their association with tumor prognosis. This study included 40 esophageal cancer patients [22 men and 18 women; average age = 62.7 ± 3.9 years; tumor-node-metasta.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.9
- DOI:
- 10.4238/2015.December.14.9
miR-218 tissue expression level is associated with aggressive progression of gastric cancer
Authors: X.X. Wang, S.J. Ge, X.L. Wang, L.X. Jiang, M.F. Sheng and J.J. Ma
The aim of the present study was to investigate the clinical significance of microRNA-218 (miR-218) in gastric cancer. We enrolled 112 patients having undergone surgery for gastric cancer between May 2008 and June 2014. Expression of miR-218 was determined by real-time quantitative reverse transcription-polymerase chain reacti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027521
- DOI:
- 10.4238/gmr.15027521
Expression of TRPM8 in diabetic rats and its relationship with visceral pain stimulation
Authors: J. Liu, S.L. Dong, N. Li, B.S. Ouyang and F. Qi
Transient receptor potential cation channel, subfamily M, member 8 (TRPM8) is a nonselective cation channel and a candidate for cold sensation signaling, but the relationship between TRPM8 and diabetes remains unclear. In the present study, we determined the expression levels of TRPM8 messenger RNA (mRNA) and the levels of the TRPM8 protein in the bladder.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017219
- DOI:
- 10.4238/gmr.15017219
Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia
Authors: A.A. Mansour, O.M. Saleh, T. Askar, A.M. Salim and A. Mergani
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion varia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.13
- DOI:
- 10.4238/2015.December.14.13
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population
Authors: Q. Xu, P.Y. Gai, H.L. Lv, G.R. Li and X.Y. Liu
Genetic factors may play an important role in frozen shoulder etiology, which may involve matrix metalloproteinase-3 (MMP3) gene polymorphisms. In this study, we examined single nucleotide polymorphisms in MMP3 for their association with frozen shoulder susceptibility in a Chinese Han population. The rs591058, rs650108, and rs679620 polymorphisms in the M.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017228
- DOI:
- 10.4238/gmr.15017228