Human Genetics
Detection of serum antinuclear antibodies in lymphoma patients
Authors: H.Y. Zou, X. Gu, W.Z. Yu, Z. Wang and M. Jiao
We investigated the presence of serum antinuclear antibodies (ANAs) and autoantibodies and their relationship with serum prognostic indicators in lymphoma patients. The study population comprised 127 patients diagnosed with lymphoma and 138 healthy control subjects. The blood samples of the participants were assayed for ANAs by immunofluorescence, and aut.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.1
- DOI:
- 10.4238/2015.December.11.1
Decreased microRNA-198 expression and its prognostic significance in human glioma
Authors: H.B. Man, W.P. Bi and H.H. Man
Previous evidence has shown the association of aberrant miR-198 expression with tumorigenesis and progression of many human malignancies. However, its involvement in human glioma is still unclear. Therefore, the aim of the current study was to investigate the expression and function of miR-198 in human gliomas. Using real-time.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027656
- DOI:
- 10.4238/gmr.15027656
Effect of CYP1A1 and GSTM1 genetic polymorphisms on bone tumor susceptibility
Authors: L. Li, J.G. Li, C.Y. Liu and Y.J. Ding
Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.7
- DOI:
- 10.4238/2015.December.11.7
Relationship between C-reactive protein levels and obstructive sleep apnea syndrome
Authors: Y.X. Tie, Y.Y. Fu, Z. Xu and Y. Peng
This study aims to determine the relationship between C-reactive protein levels and obstructive sleep apnea syndrome (OSAS). We recruited 30 OSAS patients into the observation group (OSAS group), and subdivided them into mild, moderate and severe groups according to the apnea hypopnea index. In addition, 20 normal individuals .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027808
- DOI:
- 10.4238/gmr.15027808
Genetic diversity in fragmented populations of Populus talassica inferred from microsatellites: implications for conservation
Authors: X.H. Zhu, S.P. Cheng, T. Liao and X.Y. Kang
Populus talassica Kom. is an ecologically important species endemic to central Asia. In China, its main distribution is restricted to the Ili region in the Xinjiang Autonomous Region. An understanding of genetic diversity and population structure is crucial for the development of a feasible conservation strategy. Twenty-six hi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027899
- DOI:
- 10.4238/gmr.15027899
Evaluation of the stability of reference genes in bone mesenchymal stem cells from patients with avascular necrosis of the femoral head
Authors: X.N. Wang, Q.W. Yang, Z.W. Du, T. Yu, Y.G. Qin, Y. Song, M. Xu and J.C. Wang
This study aimed to evaluate 12 genes (18S, GAPDH, B2M, ACTB, ALAS1, GUSB, HPRT1, PBGD, PPIA, PUM1, RPL29, and TBP) for their reliability and stability as reference sequences for real-time quantitative PCR (RT-qPCR) in bone marrow-derived mesenchymal stem cells (BMSCs) isolated from patients with avascular necrosis of the femo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027926
- DOI:
- 10.4238/gmr.15027926
Decreased miR-134 expression and its tumor-suppressive function in human osteosarcoma
Authors: Y. Bao, L. Peng, J. Ma, K. Liu and W. Li
Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression le.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.4
- DOI:
- 10.4238/2015.December.14.4
Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin
Authors: W.M. Lin and Z.G. Li
Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.18
- DOI:
- 10.4238/2015.December.14.18
Target replacement strategy for selection of DNA aptamers against the Fc region of mouse IgG
Authors: J. Ma, M.G. Wang, A.H. Mao, J.Y. Zeng, Y.Q. Liu, X.Q. Wang, J. Ma, Y.J. Tian, N. Ma, N. Yang, L. Wang and S.Q. Liao
Aptamers that recognize the IgG Fc region are of great interest because of their wide application as an immunology probing tool, for diagnostics, and as affinity agents for antibody purification. We developed a target replacement strategy as a modification of conventional Systematic Evolution of Ligands by EXponential enrichment (SELEX) in order to effici.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.11
- DOI:
- 10.4238/2013.April.25.11
CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population
Authors: Y.M. Guo, Z.C. Zhao, L. Zhang, H.Z. Li, Z. Li and H.L. Sun
The goal of this study was to explore the polymorphisms of CYP2C19 (CYP2C19*2, CYP2C19*3) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) on clopidogrel therapy in Zhengzhou city for guidance on clinical medication and reduction in the incidence of thromboembolic events. Two h.. Read More»
- Genet. Mol. Res. 15(2):