Human Genetics
Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A
Authors: Z. Ni, X.F. Shang, Y.F. Wang, Y.J. Sun and D.J. Fu
MicroRNAs (miRs) are associated with tumor progression in various cancers, such as gastric and hepatic carcinomas, and lung cancer. miR-301a is overexpressed and displays oncogenic activity in cancers. We investigated the biological involvement of miR-301a in osteosarcoma (OS). Quantitative real-time polymerase chain reaction .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027807
- DOI:
- 10.4238/gmr.15027807
Clinical significance of CTHRC1 protein expression in human cancers: a meta-analysis
Authors: S.F. Wang, Z. Yin, J.J. Yin, W. Zhang and C.G. Dong
The aim of this meta-analysis was to investigate the overall diagnostic and prognostic values of CTHRC1 expression in human cancer development. Based on the inclusion and exclusion criteria, 8 cohort studies were included in the meta-analysis. The data were extracted, and analyses were performed using a random-effects model. S.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027855
- DOI:
- 10.4238/gmr.15027855
Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis
Authors: L.N. Xu, N. Lin, B.N. Xu, J.B. Li and S.Q. Chen
The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.2
- DOI:
- 10.4238/2015.December.11.2
Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis
Authors: M. Zhang, L.J. Zhao, W.Q. Liang and Z.P. Mao
Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.3
- DOI:
- 10.4238/2015.December.11.3
Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer
Authors: Y.H. Liu and W.L. Zhu
In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.12
- DOI:
- 10.4238/2015.December.11.12
Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis
Authors: P. Yuan, L. Yuan, B.L. Xu, C.Z. Wang, H.Z. Yang and Y. Li
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.15
- DOI:
- 10.4238/2015.December.11.15
Influence of gender on ABCC2 expression in peripheral blood mononuclear cells
Authors: P. Sudchada, W. Chareanchim, A. Assawamakin, P. Thaipiya, W. Choochaimongkhol, N. Thiplui and P. Sukmangsa
It is known that several factors, including gender, may influence the expression of multidrug resistance associated proteins 2 (MRP2/ABCC2) in the peripheral blood mononuclear cells (PBMCs). This study aims to compare ABCC2 gene expression in PBMCs of healthy males and females. PBMCs were extracted from 48 females and 44 males, and gene expression was mea.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.18
- DOI:
- 10.4238/2015.December.11.18
Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis
Authors: J.L. Huan, X. Gao, L. Xing, X.J. Qin, H.X. Qian, Q. Zhou and L. Zhu
The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.5
- DOI:
- 10.4238/2014.September.29.5
Multi-threading the generation of Burrows-Wheeler Alignment
Authors: H. Jo
Along with recent progress in next-generation sequencing technology, it has become easier to process larger amounts of genome sequencing data at a lower cost. The most time-consuming step of next-generation sequencing data analysis involves the mapping of read data into a reference genome. Although the Burrows-Wheeler Alignmen.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028650
- DOI:
- 10.4238/gmr.15028650
Dietary glycerol for quail: association between productive performance and COX III mRNA expression
Authors: S.C.C. Silva, E. Gasparino, E. Batista, F. Tanamati, A.P.D. Vesco, B. Lala and D.P. de Oliveira
This study was carry out to evaluate mRNA expression of mitochondrial cytochrome c oxidase III in the Pectoralis superficialis muscle of 28-day-old quails fed diets containing 0, 8, and 12% glycerol. Total RNA was extracted (N = 10) and cDNA was amplified using specifics primers for qRT-PCR. Feed efficiency and feed intake wer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027435
- DOI:
- 10.4238/gmr.15027435