Human Genetics
Promoter analysis of bovine cardiomyopathy-associated protein 1 gene
Authors: G.N. Sui, Z.W. Liu, T. Wang, X. Li, X.B. Ding, X.F. Liu and H. Guo
The CMYA1 (cardiomyopathy-associated protein 1) is an actin-binding protein that plays a vital role in cardiac morphogenesis. CMYA1 is expressed specifically in the myocardial and skeletal muscle and is up-regulated in injured muscle. We therefore speculated that the bovine CMYA1 promoter might be muscle-specific. In this stud.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027675
- DOI:
- 10.4238/gmr.15027675
Serum levels of PSA, ALP, ICTP, and BSP in prostate cancer patients and the significance of ROC curve in the diagnosis of prostate cancer bone metastases
Authors: R.J. Wei, T.Y. Li, X.C. Yang, N. Jia, X.L. Yang and H.B. Song
Bone metastasis is a common complication in prostate cancer patients that can cause bone pain and pathological fracture. This study tested serum levels of prostate specific antigen (PSA), alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) in prostate cancer patients and th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027707
- DOI:
- 10.4238/gmr.15027707
Immunohistochemical subtypes of diffuse large B-cell lymphoma in the head and neck region
Authors: J.M. Li,J. Hou,L. Li and Y. Wang
The objectives of this study were to detect immunohistochemical subtypes of diffuse large B-cell lymphoma (DLBCL) of the head and neck, to compare the Hans, Choi, and Tally algorithms and to examine the significance of protein expression in these algorithms. This study included 103 DLBCL patients at Sichuan Cancer Hospital between May 2010 and October 201.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.3
Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptiblity to gestational diabetes mellitus
Authors: Y.H. Qiu, Y.L. Xu and W.H. Zhang
We investigate the role of the GSTM1, GSTT1, and GSTP1 IIe105Val genetic polymorphisms in the susceptibility to gestational diabetes mellitus. A total of 223 pregnant women with gestational diabetes mellitus and 265 healthy pregnant women were examined at The Second Affiliated Hospital of Shaanxi University of Chinese Medicine.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027711
- DOI:
- 10.4238/gmr.15027711
Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest
Authors: J.C. Zhang, W. Lu, X.M. Xie, H. Pan, Z.Q. Wu and G.T. Yang
Although therapeutic hypothermia is an effective treatment for post-resuscitation brain injury after cardiac arrest (CA), the underlying mechanism remains unclear. Vacuolar H+-ATPase (V-ATPase) plays a key role in cellular adaption to a hypoxic environment. This study sought to evaluate the effect of mild hypothermia on V-ATPa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027729
- DOI:
- 10.4238/gmr.15027729
Comparison of two methods for RNA extraction from the nucleus pulposus of intervertebral discs
Authors: M.F. Gan, H.L. Yang, J.L. Qian, C.S. Wu, C.X. Yuan, X.F. Li and J. Zou
RNA extraction from the nucleus pulposus of intervertebral discs has been extensively used in orthopedic studies. We compared two methods for extracting RNA from the nucleus pulposus: liquid nitrogen grinding and enzyme digestion. The RNA was detected by agarose gel electrophoresis, and the purity was evaluated by absorbance r.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027738
- DOI:
- 10.4238/gmr.15027738
CYFRA21-1 levels could be a biomarker for bladder cancer: a meta-analysis
Authors: L.I. Kuang,W.J. Song,H.M. Qing,S. Yan and F.L. Song
The proteolytic region of cytokeratin-19, referred to as CYFRA21-1, is a soluble molecule present in the serum and other body fluids, and is considered a tumor marker in several neoplastic diseases. To examine whether urinary or serum samples containing CYFRA21-1 can be used as biomarkers for bladder cancer, we conducted a comprehensive meta-analysis of 3.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.6
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.6
CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription
Authors: Z. Su, G. Liu, X. Song, B. Liang, X. Chang and D. Huang
The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively. In this study, .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027752
- DOI:
- 10.4238/gmr.15027752
IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population
Authors: B.L. Xu, Y.T. Li, S.X. Dong, J. Qi, H.M. Feng, L. Zi and D.Y. Yang
The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People’s Hospital between March 2013 and March .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027756
- DOI:
- 10.4238/gmr.15027756
Sequence analysis of peste des petits ruminants virus from ibexes in Xinjiang, China
Authors: J. Xia, X.G. Zheng, G.Z. Adili, Y.R. Wei, W.G. Ma, X.M. Xue, X.Y. Mi, Z. Yi, S.J. Chen, W. Du, M. Muhan, C. Duhaxi, T. Han, B. Gudai and J. Huang
Peste des petits ruminants (PPR) is an infectious disease caused by peste des petits ruminants virus (PPRV). While PPR mainly affects domestic goats and sheep, it also affects wild ungulates such as ibex, blue sheep, and gazelle, although there are few reports regarding PPRV infection in wild animals. Between January 2015 and .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027783
- DOI:
- 10.4238/gmr.15027783