Human Genetics
Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase (MTHFR) gene in southwestern Mexico.
Authors: V. Antonio-V�©jar, O. del Moral-Hern�¡ndez, L.C. Alarc�³n-Romero, E. Flores-Alfaro, M.A. Leyva-V�¡zquez, D. Hern�¡ndez-Sotelo and B. Illades-Aguiar
In this study, we examined the distribution of genotype and allele frequencies of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase gene (MTHFR) in two ethnic groups in the State of Guerrero, Mexico, which were compared with those of the Mestizo population of the region. A comparative study was cond.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.8
- DOI:
- 10.4238/2014.September.29.8
Genetic divergence between Mexican Opuntia accessions inferred by polymerase chain reaction-restriction fragment length polymorphism analysis
Authors: S. Samah, E. Valadez-Moctezuma, K.S. Pel�¡ez-Luna, S. Morales-Manzano, P. Meza-Carrera and R.C. Cid-Contreras
Molecular methods are powerful tools in characterizing and determining relationships between plants. The aim of this study was to study genetic divergence between 103 accessions of Mexican Opuntia. To accomplish this, polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis of three chloroplast interge.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027786
- DOI:
- 10.4238/gmr.15027786
Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis
Authors: R.Q. Yang, H. Teng, X.H. Xu, S.Y. Liu, Y.H. Wang, F.J. Guo and X.J. Liu
We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027826
- DOI:
- 10.4238/gmr.15027826
Assessment of genetic diversity of wheat genotypes by resistance gene analog-EST markers
Authors: O. Karakas, F. Gurel and A.A. Uncuoglu
Resistance gene analog-expressed sequence tag (RGA-EST)-based markers have been used for variety discrimination and studies of genetic diversity in wheat. Our aim is to increase the competitiveness of public wheat breeding programs through intensive use of modern selection technologies, mainly marker-assisted selection. The ge.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1065
- DOI:
- 10.4238/vol10-2gmr1065
Prader-Willi-like phenotypes: a systematic review of their chromosomal abnormalities
Authors: C.F. Rocha and C.L.A. Paiva
Prader-Willi syndrome (PWS) is caused by the lack of expression of genes located on paternal chromosome 15q11-q13. This lack of gene expression may be due to a deletion in this chromosomal segment, to maternal uniparental disomy of chromosome 15, or to a defect in the imprinting center on 15q11-q13. PWS is characterized by hyp.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.9
- DOI:
- 10.4238/2014.March.31.9
Correlation between sperm ultrastructure in infertile patients with abnormal sperm morphology and DNA damage
Authors: M. He and L. Tan
This study explored the correlation between sperm ultrastructure in infertile patients with abnormal sperm morphology and DNA damage. Three unusual sperm morphologies were selected for the experimental group namely case 1 (95% headless sperm), case 2 (98% headless sperm), and case 3 (100% headless sperm), and the control group consisted of 2 subjects (20 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.6
- DOI:
- 10.4238/2015.December.15.6
Screening for mutations in RPGR and RP2 genes in Jordanian families with X-linked retinitis pigmentosa
Authors: M.F. Haddad, O.F. Khabour, K.A.Y. Abuzaideh and W. Shihadeh
Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous disease causing progressive degeneration of retinal photoreceptor cells. X-linked RP (XLRP), in which photoreceptor degeneration begins in early childhood and complete blindness often occurs by the fourth decade of life, constitutes the most severe form of.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027842
- DOI:
- 10.4238/gmr.15027842
Association of KCNJ11 with impaired glucose regulation in essential hypertension
Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1127
- DOI:
- 10.4238/vol10-2gmr1127
miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4
Authors: Y.H. Zhang, Q.Q. Wang, H. Li, T. Ye, F. Gao and Y.C. Liu
Radiotherapy is one of the most important treatments for esophageal cancer, but radioresistance remains a major challenge. Previous studies have shown that microRNAs (miRNAs or miRs) are involved in human cancers. miR-124 has been widely reported in various cancers and it is intimately involved in proliferation, cell cycle reg.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027893
- DOI:
- 10.4238/gmr.15027893
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas
Authors: A.C. Cust�³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of se.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1125
- DOI:
- 10.4238/vol10-2gmr1125