Human Genetics
Effects of lentiviral short hairpin RNA silencing of Toll-like receptor 4 on the lens epithelial cell line HLEC
Authors: H.T. Yu and P.R. Lu
The aim of this study was to observe the proliferation of, and cell-cycle changes in, the human lens epithelial cell line HLEC after Toll-like receptor 4 (TLR4) gene silencing. HLEC cells were transfected with four TLR4-short hairpin RNA (shRNA) lentiviral vectors or the control lentivirus (pGCL-GFP-shRP-1, -2, -3, -4, NC). TL.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027897
- DOI:
- 10.4238/gmr.15027897
Additional chromosomal abnormalities in core-binding factor acute myeloid leukemia
Authors: H.H. Hsiao, Y.C. Liu, H.C. Wang, Y.F. Tsai, C.H. Wu, S.F. Cho, J.F. Hsu, C.T. Huang, S.Y. Hsiao, C.P. Lee, C.S. Chang, S.F. Lin and T.C. Liu
Despite sharing a similar genetic abnormality, patients with core binding factor acute myeloid leukemia (CBF-AML), which is characterized by the presence of t(8;21) or inv(16)/t(16;16), show heterogeneous survival. Other molecular or cytogenetic factors are supposed to have an impact on the prognosis. We enrolled 24 CBF-AML patients to determine the impac.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.3
- DOI:
- 10.4238/2015.December.16.3
Tiaogan Qingxin Granule treatment increases myocardial connexin 43 expression in a rat model of arrhythmia
Authors: J.H. Yao, C.H. Qu, L. Ma and X.Z. Chang
Myocardial ischemia-induced arrhythmia, especially ventricular arrhythmia, is the main reason for sudden cardiac death. Therefore, ischemic ventricular arrhythmia-targeted treatments are urgently needed. The mechanism of Tiaogan Qingxin Granule in premature ventricular beat (PVB) treatment was explored in arrhythmic rats pretr.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027934
- DOI:
- 10.4238/gmr.15027934
Effects of the balance between type 1 and type 2 T helper cells on ovarian cancer
Authors: C.J. Hao, J. Li, P. Liu, X.L. Li, Y.Q. Hu, J.C. Sun and Y. Wei
The balance between type 1 and type 2 T helper cells (the Th1-Th2 balance) is closely correlated with cancer, but the correlation in ovarian cancer remains unconfirmed. We investigated the Th1-Th2 balance for the diagnosis, treatment, and prognostic evaluation of ovarian cancer. Fifty healthy subjects and 50 ovarian cancer pat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027936
- DOI:
- 10.4238/gmr.15027936
Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis
Authors: X.L. Zhou and M. Wang
Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation wit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.6
- DOI:
- 10.4238/2015.December.16.6
Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Authors: R.J. Li, M. Li, G.J. Liu, Y.W. Guo, H. Bai, P. Xiao and J.Z. Mei
We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in the ERCC5 gene (rs1047768, rs751402, and rs17655) and the risk of developing gastric cancer. Between January 2013 and December 2014, samples were collected from 216 gastric cancer patients and 216 control subjects. ERCC5 rs1047768, rs751402, and rs1765.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017510
- DOI:
- 10.4238/gmr.15017510
Phenotypic expression of homozygous hemoglobin S in relation to �²-globin haplotypes, glutathione S-transferase polymorphisms and detoxification enzymes
Authors: D.G.H. Silva
Sickle cell anemia (SCA) shows a pathophysiology that involves multiple changes in sickle cell erythrocytes, vaso-occlusive episodes, hemolysis, activation of inflammatory mediators, endothelial cell dysfunction, and oxidative stress. These events complicate treatment and culminate in the development of manifestations such as .. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2ta036
- DOI:
- 10.4238/vol10-2ta036
Evaluation of alternative schemes for recording body weights in meat-type quails by using random regression
Authors: L.P. Silva, J.C. Ribeiro, C.D.S. Leite, M.F. Sousa, C.M. Bonaf�©, G.C. Caetano, A.C. Crispim and R.A. Torres
Data from 8759 meat-type quails from the UFV1 strain and 9128 from the UFV2 strain were used to assess the possibility of reducing the number of body weight records in genetic evaluations. The evaluated animals were weighed weekly since hatching to the 6th week of life, with up to 7 records of body weight for each bird. The data were evaluated by random r.. Read More»
- Genet. Mol. Res. 12(2):
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299
Authors: G.M. Chen,R.F. Ding,Y.D. Tan,X.B. Pan,G.M. Jiang,J.F. He,S.H. Lin,C. Liu and Y. Jia
Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.15
Association of LRP5 Ala1330Val polymorphism with fracture risk: a meta-analysis
Authors: J. Peng, Y. Lu, Y.J. Liu and Y.L. Zhan
Numerous studies have evaluated the association between the Ala1330Val polymorphism of the low-density lipoprotein receptor-related proteins 5 (LRP5) gene and fracture risk. However, the specific association is still controversial. The aim of this study was to investigate their correlation via meta-analysis. and EMBASE databases were searched, and data we.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017552
- DOI:
- 10.4238/gmr.15017552