Human Genetics
Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey
Authors: N.K. Turhan, S. Uygun Ilikhan, A.C. Hamamcioglu, Y. Ustundag, A. Dursun and F. Kokturk
Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibros.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.8
- DOI:
- 10.4238/2015.December.16.8
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
Authors: A. Ramos-Silva,L.E. Figuera,O.M. Soto-Quintana,A.M. Puebla-PÃ?©rez,R. RamÃ?Ârez-PatiÃ?±o,I. GutiÃ?©rrez-Hurtado,D.I. Carrillo-Moreno, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez,I.P. DÃ?¡valos-RodrÃ?Âguez and M.P. Gallegos-Arreola
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and t.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.16
Regulating effect of MMP-9 and TIMP-1 in pituitary adenoma invasion
Authors: J.H. Mao, H. Guo, N. Si, L. Qiu, L.F. Guo, Z.S. Sun, Y. Xiang, X.H. Yang, W.G. Zhao and W.C. Zhang
Pituitary adenomas can cause endocrine disorder and organ damage, with some aggressive ones leading to a high postoperative recurrence rate. The occurrence and development of these type of tumors is closely related with matrix metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs (TIMPs). In this study, the relationship between pituit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.9
- DOI:
- 10.4238/2015.December.16.9
Identification of expressed sequences in the coffee genome potentially associated with somatic embryogenesis
Authors: A.T. Silva, L.V. Paiva, A.C. Andrade and D. Barduche
Brazil possesses the most modern and productive coffee growing farms in the world, but technological development is desired to cope with the increasing world demand. One way to increase Brazilian coffee growing productivity is wide scale production of clones with superior genotypes, which can be obtained with in vitro propagation technique, or from tissue.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.1
- DOI:
- 10.4238/2013.May.21.1
Effect of siRNA targeting HER2/neu on the proliferation and viability of prostate cancer PC-3M cells
Authors: C.Y. Liu, P.C. Xu, D.G. Chen, X.H. Fan, M.Q. Li, X. Yang and Y.P. Xu
The aim of this study was to investigate the effect of a small interfering RNA (siRNA) targeting human epidermal growth factor receptor 2 (HER2/neu) on the proliferation and viability of prostate cancer PC-3M cells. Chemically synthesized siRNA targeting HER2/neu was transfected into PC-3M cells by using liposomes, and cells transfected with empty liposom.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.14
- DOI:
- 10.4238/2015.December.16.14
Analysis of genetic diversity of Laeliinae (Orchidaceae) in the State of Sergipe using ISSR markers
Authors: M.F. Arrigoni-Blank, M.S. Santos, A.F. Blank, A.R.C. Rabbani, R. Silva-Mann, J.B. Santos, A.S. Costa and T.S.A. Menezes
The Orchidaceae represent one of the largest and most diverse families on the planet. However, this family is constantly threatened by predators and by the advancement of urban centers over its natural habitats. The objective of this study was to use inter-simple sequence repeat markers to evaluate the genetic diversity betwee.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027997
- DOI:
- 10.4238/gmr.15027997
Study of the relationship between IL-10 polymorphism and serum lipoprotein levels in Han Chinese individuals
Authors: W.Q. Yang
Previous studies have shown that cytokines can affect serum lipoprotein concentrations. The aim of this study was to examine the association between IL-10 gene polymorphisms and serum lipoprotein levels of Han Chinese individuals. A total of 359 Han Chinese people were enrolled in this investigation. IL-10 -592, -819, and -108.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028016
- DOI:
- 10.4238/gmr.15028016
Single-nucleotide polymorphisms in dopamine receptor D1 are associated with heroin dependence but not impulsive behavior
Authors: J.H. Liu,H.J. Zhong,J. Dang,L. Peng and Y.S. Zhu
Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy co.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.19
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.19
Association between NOS3 genetic variants and coronary artery disease in the Han population
Authors: G.L. Zhao, Q.J. Li and H.Y. Lu
The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD). There is growing evidence that polymorphisms in NOS3 influence the progression of CAD; however, there is also a controversy regarding the association of polymorphisms in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028044
- DOI:
- 10.4238/gmr.15028044
Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group
Authors: S.H. Yildiz, M. Ozdemir Erdogan, M. Solak, O. Eser, E.S. Ar�±kan Terzi, B. Eser, V. Kocaba�� and A. Aslan
The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of t.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028051
- DOI:
- 10.4238/gmr.15028051