Human Genetics
Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population
Authors: X.Y. Yi, Q. Zhou, J. Lin, L.F. Chi and W.Z. Chi
We made a case-control study to investigate a possible association between ALOX5AP-SG13S114A/T, COX-2-765G/C, and COX-1-50C/T polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ALOX5AP-SG13S114A/T (rs1050.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.6
- DOI:
- 10.4238/2013.May.14.6
Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis
Authors: J.W. Gao, K.F. Zhang, J.S. Lu and T. Su
Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.7
- DOI:
- 10.4238/2015.December.16.7
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Authors: S.H. Ma, F.H. Ling, Y.X. Sun, S.F. Chen and Z. Li
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028066
- DOI:
- 10.4238/gmr.15028066
KLK1 A1789G gene polymorphism and the risk of coronary artery stenosis in the Chinese population
Authors: Q.D. Li, F.J. Li, X.C. Liu and H. Jiang
Previous reports have shown that polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension. The current study aimed to confirm the association between the polymorphism in KLK1 and coronary artery stenosis (CAS). A total of 458 patients with CAS and 482 controls were used in a case-control study carr.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.4
- DOI:
- 10.4238/2013.May.14.4
In vitro effect of dexmedetomidine on the respiratory burst of neutrophils
Authors: S.L. Chen, W. Zhou, F.Z. Hua, Y. Chen, X.L. Zheng, X.F. Long and J. Lu
The immunosuppressive effects of dexmedetomidine, a highly selective and widely used a2-adrenoceptor agonist for sedation, analgesia, and stress management, are investigated in vitro. In the present study, the respiratory burst of human neutrophils separated from venous blood was evaluated with dexmedetomidine treatment after .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028069
- DOI:
- 10.4238/gmr.15028069
Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population
Authors: L.J. Wang, H.T. Wang and X.X. Wang
We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014... Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028080
- DOI:
- 10.4238/gmr.15028080
3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population
Authors: L.X. Zhu,X.J. Ye,Y.G. Wang,J.J. Zhu, W.Z. Xie,Y.M. Zhao and X.Y. Lai
We investigated the relationship between a VEGF genetic polymorphism and B cell chronic lymphocytic leukemia (B-CLL). A total of 102 patients with B-CLL and 124 healthy subjects were included in this study. All individuals were typed for the rs10434 in the vascular endothelial growth factor (VEGF) gene using the TaqMan technique. We found that the A allel.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.23
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.23
No difference of complete or incomplete left-sided malignant colonic obstruction on both short- and long-term outcomes
Authors: Z.-H. Liu, C. Li, N.-Q. Huang*, M.-J. Huang, H. Peng, L. Kang
The impact of complete and incomplete colonic obstruction on the short- and long-term outcomes of malignant colorectal cancer has not yet been elucidated. The aim of this study was to investigate whether there was a difference in the impacts of the 2 types of obstruction on the short- and long-term outcomes of colorectal resec.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.10
- DOI:
- 10.4238/2014.September.29.10
Association study between matrix metalloproteinase-9 gene (MMP9) polymorphisms and the risk of Henoch-Sch�¶nlein purpura in children
Authors: E.D. Xu, Y.F. Xiao, J.J. Wang and L. Dong
Henoch-Schönlein purpura nephritis (HSPN), the most serious long-term complication of Henoch-Schönlein purpura, is one of the most common renal diseases in children. Matrix metalloproteinase-9 (MMP-9) is implicated in the pathogenesis of renal diseases. Genomic DNA was isolated from the venous blood leukocytes of 220.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028095
- DOI:
- 10.4238/gmr.15028095
Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women
Authors: D.P. Shang, H.Y. Lian, D.P. Fu, J. Wu, S.S. Hou and J.M. Lu
The purpose of this study was to evaluate single nucleotide polymorphism (SNP) variants of the estrogen receptor 1 gene (ESR1) at rs2234693 and rs9340799, as well as to investigate the relationship between ESR gene polymorphisms and postmenopausal osteoporosis (OP) of the spine in Chinese women. We recruited 198 postmenopausal.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028106
- DOI:
- 10.4238/gmr.15028106