Human Genetics
Genetic variants on 17q21 are associated with asthma in a Han Chinese population
Authors: F.-X. Li, J.-Y. Tan, X.-X. Yang, Y.-S. Wu, D. Wu and M. Li
A genome-wide study has shown an association between SNPs located on 17q21 and asthma. Such associations have been identified in several populations, but little is known about the Han Chinese population. We conducted a case-control study in a Han Chinese population to investigate the relationship between SNPs located on 17q21 .. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.10.5
- DOI:
- 10.4238/2012.February.10.5
Phylogenetic relationships of the Orang Asli and Iban of Malaysia based on maternal markers
Authors: K.C. Ang, J.W.H. Leow, W.K. Yeap, S. Hood, M.C. Mahani and B.M. Md-Zain
Malaysia remains as a crossroad of different cultures and peoples, and it has long been recognized that studying its population history can provide crucial insight into the prehistory of Southeast Asia as a whole. The earliest inhabitants were the Orang Asli in Peninsular Malaysia and the indigenous groups in Sabah and Sarawak.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1011
- DOI:
- 10.4238/vol10-2gmr1011
Variation in DNA repair gene XRCC3 affects susceptibility to astrocytomas and glioblastomas
Authors: A.C. Cust�³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
The gene XRCC3 (X-ray cross complementing group 3) has the task of repairing damage that occurs when there is recombination between homologous chromosomes. Repair of recombination between homologous chromosomes plays an important role in maintaining genome integrity, although it is known that double-strand breaks are the main .. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.10.4
- DOI:
- 10.4238/2012.February.10.4
Construction of a human Fab phage display library from antibody repertoires of osteosarcoma patients
Authors: Carmela Dantas-Barbosa, Marcelo M. BrÃ?Âgido and AndrÃ?©a Q. MaranhÃ?£o
Osteosarcoma is the commonest type of primary malignant bone tumor, frequently found in adolescents at sites of rapid bone growth. Despite current management protocols, up to half of the patients succumb to this disease. Moreover, there is no well-characterized molecular marker for diagnosis and prognosis. Since phage display .. Read More»
- Genet. Mol. Res. 4(2):
Optimization of a multiplex minisequencing protocol for population studies and medical genetics
Authors: Cl�¡udia M.B. Carvalho and S�©rgio D.J. Pena
Several technologically sophisticated high-throughput techniques have been recently developed for the study of human single nucleotide polymorphisms and the diagnosis of point mutations in human diseases. However, there is also a need for simple and inexpensive techniques suitable for clinical services and small research labor.. Read More»
- Genet. Mol. Res. 4(2):
Determination of the optimal number of markers and individuals in a training population necessary for maximum prediction accuracy in F2 populations by using genomic selection models
Authors: L.A. Peixoto, L.L. Bhering and C.D. Cruz
Genomic selection is a useful technique to assist breeders in selecting the best genotypes accurately. Phenotypic selection in the F2 generation presents with low accuracy as each genotype is represented by one individual; thus, genomic selection can increase selection accuracy at this stage of the breeding program. This study.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048874
- DOI:
- 10.4238/gmr15048874
DNA barcoding and phylogenetic relationships in Timaliidae
Authors: Z.H. Huang and D.H. Ke
The Timaliidae, a diverse family of oscine passerine birds, has long been a subject of debate regarding its phylogeny. The mitochondrial cytochrome c oxidase subunit I (COI) gene has been used as a powerful marker for identification and phylogenetic studies of animal species. In the present study, we analyzed the COI barcodes of 71 species from 21 genera .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.11
- DOI:
- 10.4238/2015.June.1.11
Overexpression of the growth arrest-specific homeobox gene Gax inhibits proliferation, migration, cell cycle progression, and apoptosis in serum-induced vascular smooth muscle cells
Authors: H. Zheng, S. Xue, Z.L. Hu, J.G. Shan and W.G. Yang
The Gax gene has been implicated in a variety of cell-developmental and biological processes, and aberrant Gax expression is linked to many diseases. In this study, to provide important insights for Gax-based gene therapy in vein graft restenosis and its anti-restenotic mechanism, we used rabbit vascular smooth muscle cells (V.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.4
- DOI:
- 10.4238/2014.March.24.4
Genetic data for 15 STR loci in a Kadazan-Dusun population from East Malaysia
Authors: B.P. Kee, L.H. Lian, P.C. Lee, T.X. Lai and K.H. Chua
Allele frequencies of 15 short tandem repeat (STR) loci, namely D5S818, D7S820, D13S317, D16S539, TH01, TPOX, Penta D, Penta E, D3S1358, D8S1179, D18S51, D21S11, CSF1PO, vWA, and FGA, were determined for 154 individuals from the Kadazan-Dusun tribe, an indigenous population of East Malaysia. All loci were amplified by polymera.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1064
- DOI:
- 10.4238/vol10-2gmr1064
microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL
Authors: X.J. Lai, X.Y. Cheng and L.D. Hu
Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048853
- DOI:
- 10.4238/gmr15048853