Human Genetics
Significance of SODD expression in childhood acute lymphoblastic leukemia and its influence on chemotherapy
Authors: H.F. Tao, Y.S. Liu, J.L. Fang, Y.Z. Su, F.H. Chen, L.Y. Zhou and Y.S. Zhu
This study explored the clinical significance of silencer of death domain (SODD) expression in childhood acute lymphoblastic leukemia (ALL) and its influence on chemotherapy as well as the effect of SODD expression on apoptosis of leukemic cells. The expression of SODD proteins in different ALL groups was determined by immunoc.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.6
- DOI:
- 10.4238/2014.March.24.6
Development of polymorphic microsatellites for Sillago sihama based on next-generation sequencing and transferability to Sillago japonica
Authors: R.X. Wu, H.R. Zhang, S.F. Niu, Y. Zhai and X.F. Liu
Sillago sihama (Forsskål, 1775), a commercially important marine fishery species in the Indo-West Pacific, is being developed as a target species for aquaculture and stock enhancement in China. However, due to the limitations of traditional isolation methods, the available microsatellite loci, or simple sequence repeats .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049046
- DOI:
- 10.4238/gmr15049046
Clinical efficacy of therapeutic intervention for subclinical hypothyroidism during pregnancy
Authors: R. Ju, L. Lin, Y. Long, J. Zhang and J. Huang
This study explored the effects of levothyroxine (L-T4) replacement therapy on pregnancy outcomes in patients with subclinical hypothyroidism (SCH). We analyzed the effects on pregnancy outcomes with respect to gestational week when the desired thyroid-stimulating hormone (TSH) level was reached as well as the length of time r.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049019
- DOI:
- 10.4238/gmr15049019
Frequency of human papillomavirus types 16, 18, 31, and 33 and sites of cervical lesions in gynecological patients from Recife, Brazil
Authors: M.F.P.T. Baldez da Silva, V. Guimar�£es, M.A.R. Silva, C.M. Medeiros do Amaral, W. Be�§ak, R.C. Stocco, A.C. Freitas and S. Crovella
Human papilloma virus (HPV) is a well-established cause of cervical cancer. While many studies have been performed so far on HPV viral biology, mode of infection and prevention measures, scanty information is available on lesion sites of infected women and the incidence of viral types at specific locations. We looked for a pos.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.1.3
- DOI:
- 10.4238/2012.March.1.3
Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients
Authors: Z.X. Ng, U.R. Kuppusamy, R. Poh, I. Tajunisah, A.C.A. Koay, K.C.S. Fong and K.H. Chua
Diabetic retinopathy is the most common diabetic eye disease, occurring in about 60% of type 2 diabetic patients. Other than known clinical risk factors, the influence of genes has been suggested as part of the development of diabetic retinopathy. We investigated the association of Gly82Ser, 1704G/T and 2184A/G polymorphisms i.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.1.2
- DOI:
- 10.4238/2012.March.1.2
Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway
Authors: Y. He, C.X. Jian, H.Y. Zhang, Y. Zhou, X. Wu, G. Zhang and Y.H. Tan
There is high incidence of periodontal disease in high-altitude environments; hypoxia may influence the proliferation and clone-forming ability of periodontal ligament stem cells (PDLSCs). The MAPK signaling pathway is closely correlated with cell proliferation, differentiation, and apoptosis. Thus, we isolated and cultured PD.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048965
- DOI:
- 10.4238/gmr15048965
Frequency of the Val1016Ile mutation on the kdr gene in Aedes aegypti (Diptera: Culicidae) in south Brazil
Authors: M.L. Collet, C. Frizzo, E. Orlandin, L.D.P. Rona, J.C. Nascimento, M.A.E. Montano, G.A. M�¼ller and G. Wagner
Recently, the number of Aedes aegypti foci has increased in west of Santa Catarina, south Brazil, which has increased concern regarding mosquito-borne disease outbreaks such as dengue fever, Zika virus, and chikungunya. Therefore, it is important to monitor genetic resistance to insecticides through “knockdown resistance.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048940
- DOI:
- 10.4238/gmr15048940
Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver
Authors: Y.W. Chen, C.H. Li, Z. Liu, J.H. Dong, W.Z. Zhang and K. Jiang
Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are rare biliary duct neoplasms. This study investigated reasonable management strategies of cystic neoplasms in the liver. Charts of 39 BCA/BCAC patients (9 males, 30 female; median age 53.74 ± 14.50 years) who underwent surgery from January 1999.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.25.1
- DOI:
- 10.4238/2014.August.25.1
Association between the polymorphisms in the ATP-binding cassette genes ABCB1 and ABCC2 and the risk of drug-resistant epilepsy in a Chinese Han population
Authors: T. Xue and Z.N. Lu
Epilepsy is a common disease of the nervous system; approximately 20-30% of all patients with epilepsy are reported resistant to antiepileptic drugs. ABCB1 and ABCC2 are members of ATP-binding cassette transporter (ABC) family that is involved in the excretion of antiepileptic drugs. In this case-control study, we have investi.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048752
- DOI:
- 10.4238/gmr15048752
Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia
Authors: S. Sogut, Z. Yonden, H. Kaya, S. Oktar, M. Tutanc, H.R. Yilmaz, A. Yigit, N. Ozcelik and E. Gali
Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle c.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1106
- DOI:
- 10.4238/vol10-2gmr1106