Human Genetics

Value of C-arm computed tomography in radiofrequency ablation of small lung lesions

Authors: X.Q. Li, Y. Zhang, D.B. Huang, J. Zhang, G.S. Zhang, Z.X. Wen, J.H. Li and H.L. Liu

This study aimed to explore the value of C-arm computed tomography (CT) applications in radiofrequency ablation (RFA) of small lung lesions. The puncture success rate, cumulative survival rate, tumor response rate, complications, and radiation dose during C-arm CT-guided RFA of 36 small lung lesions in 34 patients were analyze.. Read More»

Genet. Mol. Res. 13(3):

2014.August.7.17

DOI:

10.4238/2014.August.7.17

Low metallothionein 1M expression association with poor hepatocellular carcinoma prognosis after curative resection

Authors: J. Ding and S.C. Lu

According to the typical clinical characteristics of hepatocellular carcinoma (HCC), recurrence and prognosis can differ dramatically between patients. Using RNA sequencing, we identified differential expression of the gene metallothionein 1M (MT1M) by comparing early-recurrence HCC (N = 11), no-recurrence HCC (N = 10), and no.. Read More»

Genet. Mol. Res. 15(4):

gmr.15048735

DOI:

10.4238/gmr.15048735

Contribution of the GSTP1 gene polymorphism to the development of osteosarcoma in a Chinese population

Authors: W.R. Qu, J. Wu and R. Li

We conducted a case-control study to investigate the associations between GSTT1, GSTM1, and GSTP1 gene polymorphisms and development of osteosarcoma in a Chinese population. Between January 2013 and February 2015, 153 patients diagnosed with osteosarcoma and 252 control subjects were enrolled in the current study from the Orthopedic Hospital of the Second.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038034

DOI:

10.4238/gmr.15038034

Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population

Authors: C.Y. Bai, X.Y. Shi, J. He, J. Xue and Y. Feng

We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment .. Read More»

Genet. Mol. Res. 15(3):

gmr.15038116

DOI:

10.4238/gmr.15038116

Comments to the paper by Benites et al.

Authors: Nersesyan AK

Genet. Mol. Res. 6(1):

Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats

Authors: Y.-H. Qi, W.-L. Yao, C.-H. Zhang and Y.-Q. Guo

This study investigated cadherin-1 (Cdh1) expression in the sensorimotor cortex of rats after spinal cord injury (SCI). The repairing effect of Cdh1 was evaluated by silencing its expression with lentivirus-mediated RNAi. Twenty male Sprague-Dawley (SD) rats were randomly divided into a normal group and an operation group. Rat.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.February.28.9

DOI:

http://dx.doi.org/10.4238/2014.February.28.9

Analysis of minicircle sequences of kDNA obtained from clinical samples (lesions and scars) of patients with American cutaneous leishmaniasis in Pernambuco State, Brazil

Authors: Gomes Rodrigues EH

The present study demonstrates multiple alignment of minicircle sequences, where size polymorphisms (ranging from 518-797 bp) were present, as well as sequence polymorphisms, indicating significant heterogeneity of classes, particularly in minicircles amplified from active cutaneous lesions. The minicircle sequences obtained f.. Read More»

Genet. Mol. Res. 6(1):

A novel COMP mutation in an Inuit patient with pseudoachondroplasia and severe short stature

Authors: A.M. Elliott, P. Bocangel, M.H. Reed and C.R. Greenberg

Pseudoachondroplasia (PSACH) is an autosomal dominant skeletal dysplasia, generally identified clinically at two years of age due to decreased linear growth and a waddling gait. Radiographic features include small and irregular epiphyses, with metaphyseal changes of the long bones and characteristic vertebral changes. Mutation.. Read More»

Genet. Mol. Res. 9(3):

vol9-3gmr897

DOI:

10.4238/vol9-3gmr897

Effects of ganglioside GM1 and neural growth factor on neural stem cell proliferation and differentiation

Authors: Q. Wang, Y.H. Song, Z. Tang, Z.P. Wang, Q. Xu and N. Bao

Neurogenesis, recovery from nerve injury, neurodegeneration, and Parkinson’s disease affect people’s health, yet the underlying molecular mechanisms remain elusive. Here, we investigated the effect of ganglioside GM1 and neural growth factor (NGF) on neural stem cell (NSC) proliferation and differentiation in vitro to provide a scientific basi.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038376

DOI:

10.4238/gmr.15038376

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer�s disease

Authors: L. Ma and Z.N. Lu

In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer’s disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorph.. Read More»

Genet. Mol. Res. 15(4):

gmr.15048740

DOI:

10.4238/gmr.15048740