Human Genetics
Neuroprotective effects of Bcl-2 overexpression on nerve cells of rats with acute cerebral infarction
Authors: H.R. Zhang, J.H. Peng, G.Y. Zhu and R.X. Xu
We aimed to investigate the influence of lentiviral-mediated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.15
- DOI:
- 10.4238/2015.July.13.15
Functional screening for cellulolytic activity in a metagenomic fosmid library of microorganisms associated with coral
Authors: F.M.O. Sousa, S.R. Moura, C.A. Quinto, J.C.T. Dias, C.P. Pirovani and R.P. Rezende
Cellulases are enzymes that degrade cellulosic materials. Cellulose is the most abundant renewable carbon resource on Earth, and cellulases are used in various industrial sectors. Although cellulases are obtained from a variety of sources, this is the first description of cellulolytic activity isolated from a coral metagenomic.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048770
- DOI:
- 10.4238/gmr.15048770
Comparison and analysis of Wuding and avian chicken skeletal muscle satellite cells
Authors: H.Q. Tong, Z.Q. Jiang, T.F. Dou, Q.H. Li, Z.Q. Xu, L.X. Liu,D.H. Gu, H. Rong, Y. Huang, X.B. Chen, M. Jois, M.F.W. te Pas, C.R. Ge and J.J. Jia
Chicken skeletal muscle satellite cells are located between the basement membrane and the sarcolemma of mature muscle fibers. Avian broilers have been genetically selected based on their high growth velocity and large muscle mass. The Wuding chicken is a famous local chicken in Yunnan Province that undergoes non-selection bree.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048815
- DOI:
- 10.4238/gmr.15048815
Screening for fragile X syndrome among Brazilian mentally retarded male patients using PCR from buccal cell DNA
Authors: D.M. Christofolini, M.V.N. Lipay, M.A.P. Ramos, D. Brunoni and M.I. Melaragno
Fragile X syndrome is one of the most frequent causes of mental retardation. Since the phenotype in this syndrome is quite variable, clinical diagnosis is not easy and molecular laboratory diagnosis is necessary. Usually DNA from blood cells is used in molecular tests to detect the fragile X mutation which is characterized by .. Read More»
- Genet. Mol. Res. 5(3):
Duffy blood group genotypes among African-Brazilian communities of the Amazon region
Authors: Perna SJQ, Cardoso GL and Guerreiro JF
Duffy blood group genotype was studied in 95 unrelated subjects from four African-Brazilian communities of the Amazon region: Trombetas, Pitimandeua, Curiaú, and Mazagão Velho. Genotyping was performed using an allele-specific primer polymerase chain reaction technique for determining the three major alleles at F.. Read More»
- Genet. Mol. Res. 6(1):
Evaluation of HPFH and �´�²-thalassemia mutations in a Brazilian group with high Hb F levels
Authors: G.C.S. Carrocini, L.S. Ondei, P.J.A. Zamaro and C.R. Bonini-Domingos
Fetal hemoglobin (Hb F) is characteristic of the fetal development period. However, in some genetic conditions, such as hereditary persistence of fetal hemoglobin (HPFH) and delta-beta thalassemia (δβ-thalassemia), Hb F continues to be produced in adulthood. We evaluated the frequency of two mutations of HPFH, HPFH-.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.21.3
- DOI:
- 10.4238/2011.December.21.3
Association between the CYP11B2 gene Ã?Â?344T>C polymorphism and coronary artery disease: a meta-analysis
Authors: Y. Liu, H.L. Liu, W. Han, S.J. Yu and J. Zhang
Numerous studies have evaluated the association between the CYP11B2 gene Ã?Â?344T>C polymorphism and coronary artery disease (CAD) risk. However, the specific association is still controversial. To address this issue, PubMed, EMBASE, and China National Knowledge Infrastructure databases were searched for eligible articles that reported on the relations.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.22
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.22
Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis
Authors: X.L. Zhang, X.J. Zhang, Y. Chen, Y.M. Zhang, Q. Zhang,C.X. Cao, D.Y. Gu, J.F. Shi, Y.L. Gong, J.F. Chen and C.J. Tang
A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was signifi cantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this p.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.10
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.10
S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes
Authors: Y.-Y. Zheng, X. Xie, Y.-T. Ma, Y.-N. Yang, Z.-Y. Fu, X.-M. Li, F. Liu, S.-J. Yang, X. Ma and B.-D. Chen
C5L2, a G protein-coupled receptor, is known to be a functional receptor of acylation-stimulating protein, which is a stimulator of triglyceride synthesis and glucose transport. A novel C5L2 variant (S323I) was identified and its association with familial combined hyperlipidemia (FCH) was recently reported. We looked for this .. Read More»
- Genet. Mol. Res. 10(4):
Heterogeneity and diversity of ABO and Rh blood group genes in select Saudi Arabian populations
Authors: E.S. AlSuhaibani, N.A. Kizilbash and S. Malik
In order to investigate the diversity of ABO and Rh blood group genes in the Saudi Arabian population, we assembled the phenotypic data of approximately 66,000 subjects from ten representative Saudi populations: Al-Khobar, Riyadh, Tabuk/Madina Al-Munawaara, Jeddah, Abha, South region, Sakaka, Domah, Al-Qurayat, and Sweer. The frequencies of p[A], q[B], an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.11
- DOI:
- 10.4238/2015.July.14.11