Human Genetics
Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population
Authors: R.P. Lin, C.Y. Yao and D.X. Ren
Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 ca.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.25
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.25
Effects of intravenous analgesia with combined dezocine and butorphanol on postoperative cognitive function in elderly patients
Authors: B.X. Ren, J. Zong, J.C. Tang, D.P. Sun, X. Hui, R.Q. Li, J.L. Zhang and Y. Ji
The aim of this study was to observe the analgesic effects of the combination of dezocine and butorphanol on postoperative cognitive function in elderly patients. Forty elderly patients undergoing upper abdominal surgeries or thoracotomies with general anesthesia were randomly divided into the dezocine and butorphanol group or the butorphanol group (20 pa.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.8
- DOI:
- 10.4238/2015.May.25.8
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?
Authors: H.I. G�¶z�¼, S. ��z�§elik, M. Alo��lu, A. ��ahin, S. Temiz, A. Dayan, H. Cengiz, Y. T�¼t�¼nc�¼ and R. Bircan
The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkis.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038504
- DOI:
- 10.4238/gmr.15038504
Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose
Authors: Z.P. Feng, H.C. Deng, R. Jiang, J. Du and D.Y. Cheng
We investigated the effect of p38MAPK/AP-1 (activator protein-1) signaling on the apoptosis of osteoblasts induced by high glucose. A lentivirus vector of small hairpin RNA (shRNA) targeting p38MAPK was constructed in vitro. Osteoblasts MC3T3-E1 cultured in vitro were treated with vehicle, high glucose, p38MAPK-shRNA transfection, p38MAPK inhibitor, and u.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.26
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.26
Increased micronucleus frequency in exfoliated cells of the buccal mucosa in hairdressers
Authors: L.N. Rickes, M.C. Alvarengo, T.M. Souza, G.L. Garcias and M.G. Martino-Roth
Hairdressers are exposed daily to chemical substances, such as dyes, chemical straighteners and curling chemicals, which can be absorbed, inhaled or possibly ingested. We analyzed the frequency of micronuclei (MNC) in exfoliated cells of the buccal mucosa of 50 hairdressers and 50 controls in Pelotas, RS, Brazil. An assessment.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr941
- DOI:
- 10.4238/vol9-3gmr941
Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women
Authors: C. Sun, Q. Zhang, B. Hu and K. Zhang
We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038355
- DOI:
- 10.4238/gmr.15038355
Lack of association between SNP rs3914132 of the RELN gene and otosclerosis in India
Authors: S. Priyadarshi, K.C. Panda, A.K. Panda and P.V. Ramchander
Otosclerosis (MIM 166800) is primarily a metabolic bone disorder of the otic capsule, which leads to bony fixation of the stapedial footplate in the oval window; it is among the most common causes of acquired hearing loss. The etiology of this disease is largely unknown, although epidemiological studies suggest the involvement.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr890
- DOI:
- 10.4238/vol9-3gmr890
Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese
Authors: H.G. Wang, J.L. Wang, P. Chang, F.L. Cao4, X.C. Liu, Y.B. Ma, G.X. Zhai and H.Q. Gao
We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr946
- DOI:
- 10.4238/vol9-3gmr946
Distinct non-cerebrovascular risk factors for ischemic lacunar stroke and non-lacunar stroke: preliminary results
Authors: Y.F. Chen, C.H. Luo, Y.J. Liu, W.H. Lu and B.R. Su
Stroke is a non-communicable disease of increasing socioeconomic importance in aging populations. This study compared the risk factors implicated in two subtypes of ischemic stroke: lacunar stroke (LS) and non-lacunar stroke (NLS). A retrospective case control study was conducted on a total of 368 patients [220 cases (59.8%) of NLS and 148 cases (40.2%) o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.28
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.28
Cost-effective analysis of genotyping using oral cells in the geriatric population
Authors: T. JuÃ?¡rez-Cedillo, S. SÃ?¡nchez-GarcÃ?Âa, J.F. Mould-Quevedo, C. GarcÃ?Âa-PeÃ?±a, J.J. Gallo3, F.A. Wagner and G. Vargas-AlarcÃ?³n
We evaluated the cost-effectiveness of using buccal swab brushes in comparison with blood samples for obtaining DNA for large epidemiological studies of the elderly population. The data reported here are from the third phase of the Integral Study of Depression among the Elderly in Mexico City’s Mexican Institute of Socia.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr939
- DOI:
- 10.4238/vol9-3gmr939