Human Genetics
Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease
Authors: K. Wang, P.S. Dong, H.F. Zhang, Z.J. Li, X.M. Yang and H. Liu
We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 Ã?Â?174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polym.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.29
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.29
Effects of AFP gene silencing on Survivin mRNA expression inhibition in HepG2 cells
Authors: Z.L. Fang, N. Fang, X.N. Han, G. Huang, X.J. Fu, G.S. Xie, N.R. Wang and J.P. Xiong
We investigated the effects of alpha-fetoprotein (AFP) gene silencing on Survivin expression in HepG2 cells. Small interfering RNA technology was used to downregulate AFP expression in HepG2 cells. An enzyme-linked immunosorbent assay was used to measure AFP concentration in the supernatant before and after transfection. An MTT assay was used to detect ce.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.30
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.30
TNFR1 -383 AÃ?Â?C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study
Authors: V. Mordovskii, A. Semenchukov, S.Y. Nikulina, A.B. Salmina, A. Chernova, E. Kapustina, A. Kents, A. Ohapkina, E. Moskaleva, P.E. Maltese, P. Convertini, M. Bertelli
The aim of this study was to assess the association between the TNFR1 rs2234649 polymorphism and ankylosing spondylitis susceptibility in a Russian Caucasian population. A total of 41 ankylosing spondylitis patients and 43 healthy controls, matched according to age and sex, were enrolled, and polymerase chain reac.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019581
- DOI:
- 10.4238/gmr16019581
Benefits of minimizing immunosuppressive dosage according to cytochrome P450 3A5 genotype in liver transplant patients:findings from a single-center study
Authors: L. Wang, N. Li, M.X. Wang and S.C. Lu
We evaluated the clinical efficacy of tailoring tacrolimus dosage to cytochrome P450 (CYP) 3A5 genotype in liver transplant patients. One hundred patients who received tacrolimus-based therapy were included in the retrospective study in which the relationship between the tacrolimus blood trough concentration/dosage ratio and the CYP3A5 genotype of both do.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.31
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.31
Standardization of a molecular method for epidemiologic identification of Leishmania strains
Authors: R.F. Rocha, E.V. Menezes, A.R.E.O. Xavier, V.A. Royo, D.A. Oliveira, A.F.M. J�ºnior, E.S. Dias, A.C.V.M.R. Lima and E.M. Michalsky
Molecular studies of the evolutionary relationships among Leishmania species suggest the presence of high genetic variation within this genus, which has a direct effect on public health in many countries. The coexistence of species in a particular region can result in different leishmaniasis clinical forms and treatment respon.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048854
- DOI:
- 10.4238/gmr.15048854
Naturally fragmented but not genetically isolated populations of Podocarpus sellowii Klotzsch (Podocarpaceae) in southeast Brazil
Authors: F.R. Gon�§alves, F.A. Vieira and D. Carvalho
In southeastern Brazil, the majority of the riparian ecosystems are fragmented and degraded mainly due to human activities. The perennial gymnosperm Podocarpus sellowii Klotzch is a typical tree species from a gallery forest in the rupestrian area. Ten alloenzymatic loci were used to estimate the allelic frequency of 232 indiv.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048871
- DOI:
- 10.4238/gmr.15048871
Assessment of the link between Vitamin D receptor TaqI gene polymorphism and periodontitis: a meta-analysis in a Chinese population
Authors: X.W. Ji, Y. Wang, C. Cao and L.J. Zhong
Although a number of studies have been conducted to determine the association between vitamin D receptor (VDR) TaqI polymorphism and periodontitis in the Chinese population, this association remains elusive. To assess the influence of VDR TaqI polymorphism on the risk of periodontitis, a meta-analysis was performed in a Chines.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048883
- DOI:
- 10.4238/gmr.15048883
Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha
Authors: X.G. Gao, J.B. Han, Z.C. Lu, P.J. Zhang and C.B. He
The major histocompatibility complex (MHC) is one of the most important genetic systems associated with resistance to infectious diseases in vertebrates. The spotted seal (Phoca largha) is one of the most endangered species in China. In this study, we present the first step in the molecular characterization of a DRB-like locus in the spotted seal by analy.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.15
- DOI:
- 10.4238/2015.March.20.15
Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design
Authors: W.L. Xu, J.L.T. Tayerjiang, X.B. Zhao, H. Wang, Q. Wang and H. Yuan
The aim of the study was to optimize the biological safety scheme of spinal image-guided radiotherapy (IGRT) by determining the expression of caspase-3 in spinal cord neurons after IGRT. Thirty-six adult male beagles were assigned according to a random number table and subjected to IGRT to the 7th-12th canine thoracic vertebral bodies under a total dose o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.1
Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease
Authors: S. Sahin, K. Ceyhan, I. Benli, H. Ozyurt, E. Naseri, M.M. Tumuklu, L. Aydogan, A.O. Elalmis, A.F. Ozugurlu and O. Onalan
We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.16
- DOI:
- 10.4238/2015.March.20.16