Human Genetics

Analysis of the 19 Y-STR and 16 X-STR loci system in the Han population of Shandong province, China

Authors: H.M. Gao, C. Wang, S.Y. Han, S.H. Sun, D.J. Xiao, Y.S. Wang, C.T. Li, M.X. Zhang

H.M. Gao C. Wang S.Y. Han S.H. Sun D.J. Xiao Y.S. Wang C.T. Li M.X. Zhang The sex-linked short tandem repeats (STR), Y-STR and X-STR, are important for autosomal STRs in forensic paternity testing. We evaluated the forensic parameters of 19 Y-STRs and 16 X-STRs in the Han population of Shandong pro.. Read More»

Genet. Mol. Res. 16(1):

gmr16019573

DOI:

10.4238/gmr16019573

Protein-protein interaction network and mechanism analysis of hepatitis C

Authors: Y. Tang, Q. Tang, C. Dong, X. Li, Z. Zhang and F. An

We predicted potential genes and identified pathways associated with hepatitis C. The gene expression profiles of GSE40184 from blood samples and GSE38597 from liver biopsy samples were downloaded from the GEO database. Differentially expressed genes (DEGs) were recognized using the Limma Package. The Pearson correlation test was used to construct the co-.. Read More»

Genet. Mol. Res. 14(1):

2015.March.20.17

DOI:

10.4238/2015.March.20.17

Development and validation of single nucleotide polymorphism markers in Odontobutis potamophila from transcriptomic sequencing

Authors: H.W. Zhang, S.W. Yin, L.J. Zhang, X.Y. Hou, Y.Y. Wang and G.S. Zhang

Transcriptome sequencing technology has been applied in the development and discovery of single nucleotide polymorphism (SNP) markers in fish. In this study, a panel of 120 expressed sequence tag (EST)-derived SNPs was selected by several selection filters from the resultant EST library of Odontobutis potamophila using Illumina Sequencing. In total, 37 SN.. Read More»

Genet. Mol. Res. 14(1):

2015.March.20.18

DOI:

10.4238/2015.March.20.18

Oxidative stress in sickle cell patients: influence of haplotypes and specific medication

Authors: E. Belini J�ºnior

Genet. Mol. Res. 9(2):

vol9-2ta031

DOI:

10.4238/vol9-2ta031

Evaluation of angiotensin-converting enzyme and adenosine deaminase polymorphisms in patients with type 2 diabetes mellitus

Authors: A.C.B. Domingos

Genet. Mol. Res. 9(2):

vol9-2ta030

DOI:

10.4238/vol9-2ta030

Replication timing regulation in adults with chromosomal balance rearrangements

Authors: Y. Xie, J. Wu, S. Lin, Y. Zhou, Q. Fang and X. Sun

The alternative forms of the alleles in biallelic genes display a synchronous pattern of replication that is different from genes subjected to monoallelic expression, which exhibit an asynchronous mode of replication. The present study sought to gain insight into changes in the allele-specific replication timing in phenotypically normal humans with balanc.. Read More»

Genet. Mol. Res. 14(3):

2015.July.14.9

DOI:

10.4238/2015.July.14.9

A Cu/Zn superoxide dismutase from Jatropha curcas enhances salt tolerance of Arabidopsis thaliana

Authors: Z.B. Liu, W.J. Zhang, X.D. Gong, Q. Zhang and L.R. Zhou

Superoxide dismutases (SODs) are involved in protecting plants against diverse biotic and abiotic stresses. In the present study, a novel Cu/Zn-SOD gene (JcCu/Zn-SOD) was cloned from Jatropha curcas L. Quantitative reverse transcription-polymerase chain reaction analysis revealed that JcCu/Zn-SOD is constitutively expressed in different tissues of J. curc.. Read More»

Genet. Mol. Res. 14(1):

2015.March.20.19

DOI:

10.4238/2015.March.20.19

CCR2-64I is a risk factor for development of bladder cancer

Authors: K.F. Narter, B. Agachan, S. Sozen, Z.B. Cincin and T. Isbir

Chemokines are potent proinflammatory cytokines that are implicated in numerous inflammatory diseases. Proinflammatory gene polymorphisms lead to variations in the production and concentration of inflammatory proteins. We investigated a possible association between polymorphisms in chemokine and chemokine receptor genes (MCP-1.. Read More»

Genet. Mol. Res. 9(2):

vol9-2gmr829

DOI:

10.4238/vol9-2gmr829

Formation of and countermeasures for subacute coronary stent thrombosis in elderly diabetic patients

Authors: Z.-F. Li, Y.-P. Zhang, Z.-Q. Qin, X.-L. Li, C.-H. Gao, S. Yang and Z.-J. Chen

The aim of this study was to evaluate and investigate the pathogenetic mechanism and countermeasures of subacute thrombosis (SAT) after coronary stenting in elderly diabetic patients. The clinical characteristics and pathogenetic mechanisms in 3 cases of SAT after stent implantations in elderly diabetic patients were retrospec.. Read More»

Genet. Mol. Res. 13(3):

2014.August.7.26

DOI:

10.4238/2014.August.7.26

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer

Authors: J.-L. Zhang, Q. Yao, J.-H. Chen ,Y. Wang, H. Wang, Q. Fan, R. Ling,J. Yi and L. Wang

The objective of this study was to determine the changes in peripheral blood circulating tumor cells in HER2-positive early breast cancer before and after Herceptin therapy, and to explore the effects of the HER2 gene and Herceptin on circulating tumor cells. CK19 mRNA expression in peripheral blood was evaluated by qRT-PCR as an index of circulating tumo.. Read More»

Genet. Mol. Res. 14(1):

2015.March.20.20

DOI:

10.4238/2015.March.20.20