Human Genetics
A new method to induce myasthenia gravis models and the protective effect of soluble decay accelerating factors
Authors: L. Sun, L. Xing, G.H. Zhang and S.Y. Pan
It is expensive to induce experimental autoimmune myasthenia gravis (EAMG) by active immunity, and difficult to obtain natural acetylcholine receptor (AChR). We sought a new method of inducing EAMG by immunizing rats with artificially synthesized AChR. The AChR mRNA in TE671 cells was extracted and reverse transcribed. The inclusion body was purified and .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.4
- DOI:
- 10.4238/2015.July.14.4
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, N. Syeed, M.Z. Banday, S.M. Bashir, B.A. Bhat and M.A. Siddiqi
Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to dete.. Read More»
- Genet. Mol. Res. 9(2):
- 0.4238/vol9-2gmr751
- DOI:
- 0.4238/vol9-2gmr751
Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese womenc
Authors: H. Lin, Z. Yin, X.Y. Yu, N. Lin, Y. Lin, J. Chen, Y.Z. Chen, K.P. Lu and H.K. Liu
We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) w.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.28
- DOI:
- 10.4238/2014.August.7.28
IL-10 and IL-12B gene polymorphisms in a multiethnic Malaysian population
Authors: S.S. Sam, B.T. Teoh and S. AbuBakar
Inheritance of polymorphisms in the interleukin (IL)-10 promoter and IL-12B genes, which influence cytokine production and activities, may define the balance in T helper response in infection and autoimmune diseases. In the present study, we investigated the distribution of the IL-10 promoter and IL-12B gene polymorphisms in a multiethnic Malaysian popula.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.4
Staging of type 2 diabetes mellitus
Authors: S.L. Wu
There is currently no reported staging system for type 2 diabetes mellitus. Here, I attempted to stage type 2 diabetes mellitus in order to help clinicians, patients, and other interested individuals to effectively evaluate patient conditions... Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.22
- DOI:
- 10.4238/2015.March.20.22
Differentiation-inducing effects of betamethasone on human glioma cell line U251
Authors: T. Jin, Y.X. Wang, K. Fan, D.B. Tao, X. Dong and J.S. Shen
We studied the differentiation-inducing effect of betamethasone on human glioma cell line U251 cultured in vitro, and the underlying mechanism. U251 cells were divided into two groups: control group cells, cultured in Dulbecco’s Modified Eagle’s medium containing 10% fetal bovine serum; and medication group cells, treated with 15 μM betamet.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.10
- DOI:
- 10.4238/2015.July.14.10
Repeated whole-lung lavage for unremitting pulmonary alveolar proteinosis: a eight-year follow-up of a case
Authors: F. Gao, G.C. Lu, X.Y. Zhou, Z. Yu, H.M. Wang and T. Bian
Pulmonary alveolar proteinosis (PAP) is a rare clinical syndrome that was first described in 1958. To date, whole-lung lavage (WLL) is still the gold-standard therapy for PAP. Herein, we report the case of a male patient who was diagnosed with PAP by open-lung biopsy 8 years prior to presentation at our clinic. The man underwe.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.29
- DOI:
- 10.4238/2014.August.7.29
Immune protective mechanism of rMOMP protein ophthalmic vaccine regarding intraocular hypertension and retinal optic nerve injury in rats
Authors: X.Y. Xin, F.Y. Sun and L.L. Gao
The aim of this study was to explore the immune protective mechanism of rMOMP protein vaccine in intraocular hypertension and retinal optic nerve injury in rats. The rMOMP protein ophthalmic vaccine was prepared and quality-controlled. Sixty normal adult SD rats were randomly divided into two groups to establish a chronic ocular hypertension model and an .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.5
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.5
Effect of skeletal muscle fibers on porcine meat quality at different stages of growth
Authors: F. Wu, J.J. Zuo, Q.P. Yu, S.G. Zou, H.Z. Tan, J. Xiao, Y.H. Liu and D.Y. Feng
In this study, we examined changes in meat quality and content of muscle types during porcine growth. The influence of the longissimus dorsi muscle fiber composition on meat quality and the correlation between 2 fiber-typing methods (histochemistry and real-time quantitative polymerase chain reaction) were examined. Type IIx and type IIb fibers accounted .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.13
- DOI:
- 10.4238/2015.July.14.13
Expression of microRNA-106b and its clinical significance in cutaneous melanoma
Authors: N. Lin, Y. Zhou, X. Lian and Y. Tu
MicroRNA-106b (miR-106b) is overexpressed in various types of cancers and is associated with the regulation of carcinogenic processes. However, its clinical significance in cutaneous melanoma has not been reported. qRT-PCR was performed to examine the expression of miR-106b in 15 cases of dysplastic nevi, 17 cases of melanoma metastases, and 97 cases of p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015